Protein Alignment NEK4 and niki

DIOPT Version :10

• Sequence 1: XP_016862574.1
• Gene: NEK4 / 6787
• HGNCID: 11399
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_651293.1
• Gene: niki / 42959
• FlyBaseID: FBgn0045980
• Length: 841
• Species: Drosophila melanogaster
• Alignment Length: 570
• Identity: 162/570 - (28%)
• Similarity: 249/570 - (43%)
• Gaps: 96/570 - (16%)

Human     3 LAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVT 67
            ||.|..:||||:||:|...|.:.:.||.|.|.|::||...|...|..|..|..:.|:|.|||||:
  Fly   102 LANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVS 166

Human    68 YKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQL-LPENQVVEWFVQIAMALQYLHEKHILHRD 131
            |..|:. .|..|.|.|.:.:||.|.:.:.|::|:| .||..::..|.||:.|:.|:|.::|||||
  Fly   167 YLGSFI-KDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRD 230

Human   132 LKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCV 196
            |||.||||.|..|:|:||.||::::..... |.|::|||||.|||:...|.|:.|||:|||||.:
  Fly   231 LKTANVFLNRRGIVKIGDFGISKIMNTKIH-AQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCIL 294

Human   197 YEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQ--P 259
            .||..||..|.|.:::.||.:|:.|...|:|..|:..|..|:..:|......||:...:|..  |
  Fly   295 GEMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIP 359

Human   260 YIKR--------------------------------QISFFLEATKIKTSKNNIKNGDS------ 286
            .|.|                                .:|..||....:|....:...|:
  Fly   360 LIFRSLGKNKGYSYEDDVGGPGSDQLTAPVPAAAYSNVSMELELPTAQTETKQLMIADTAAPHEI 424

Human   287 ----------------------QSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQ 329
                                  |..|.|.:|......:|.|:    ::.:|| .|..|||
  Fly   425 LEKRSVLYQLKAFGTCFSMAPIQLPPKAVIVDVAMSDSHFVV----VNEDGS-AYAWGEG----- 479

Human   330 EKPRASGLLKSPASLKAHTCKQDLSNTTELATISSVNIDILPAKGRDSVSDG------FVQENQP 388
             .....||....|.....:..:.:.|...::..:.....||..:....:|.|      ..|:.|.
  Fly   480 -THGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQR 543

Human   389 RYLDASNELGGICSISQVEEEMLQDNTKS--SAQPENLIPMWSSD----IVTGEKNEPVK-PLQP 446
            .|  .|.:|  |..::.|..|.:....:.  :...|..:.:|.:.    :..|...:..| |.:.
  Fly   544 NY--HSPKL--IARLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQKI 604

Human   447 LIKEQKPKDQSLALSPKLECSGTILAHSNLRLLGSSD-SPASASRVAGIT 495
            |:...|.|...:...|  :.|..:.|:..|.:.||:| :.....|.|.||
  Fly   605 LLSHVKTKPSKIYCGP--DTSAVLFANGELHVCGSNDYNKLGFQRSAKIT 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK4	XP_016862574.1	STKc_Nek4	5..261	CDD:270862	106/258 (41%)
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	105/256 (41%)
		ATS1	433..749	CDD:444065	47/237 (20%)