DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NEK4 and niki

DIOPT Version :9

Sequence 1:	XP_016862574.1	Gene:	NEK4 / 6787	HGNCID:	11399	Length:	870	Species:	Homo sapiens
Sequence 2:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	162/570 - (28%)
Similarity:	249/570 - (43%)	Gaps:	96/570 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     3 LAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVT 67
            ||.|..:||||:||:|...|.:.:.||.|.|.|::||...|...|..|..|..:.|:|.|||||:
  Fly   102 LANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVS 166

Human    68 YKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQL-LPENQVVEWFVQIAMALQYLHEKHILHRD 131
            |..|:. .|..|.|.|.:.:||.|.:.:.|::|:| .||..::..|.||:.|:.|:|.::|||||
  Fly   167 YLGSFI-KDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRD 230

Human   132 LKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCV 196
            |||.||||.|..|:|:||.||::::..... |.|::|||||.|||:...|.|:.|||:|||||.:
  Fly   231 LKTANVFLNRRGIVKIGDFGISKIMNTKIH-AQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCIL 294

Human   197 YEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQ--P 259
            .||..||..|.|.:::.||.:|:.|...|:|..|:..|..|:..:|......||:...:|..  |
  Fly   295 GEMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIP 359

Human   260 YIKR--------------------------------QISFFLEATKIKTSKNNIKNGDS------ 286
            .|.|                                .:|..||....:|....:...|:
  Fly   360 LIFRSLGKNKGYSYEDDVGGPGSDQLTAPVPAAAYSNVSMELELPTAQTETKQLMIADTAAPHEI 424

Human   287 ----------------------QSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQ 329
                                  |..|.|.:|......:|.|:    ::.:|| .|..|||
  Fly   425 LEKRSVLYQLKAFGTCFSMAPIQLPPKAVIVDVAMSDSHFVV----VNEDGS-AYAWGEG----- 479

Human   330 EKPRASGLLKSPASLKAHTCKQDLSNTTELATISSVNIDILPAKGRDSVSDG------FVQENQP 388
             .....||....|.....:..:.:.|...::..:.....||..:....:|.|      ..|:.|.
  Fly   480 -THGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQR 543

Human   389 RYLDASNELGGICSISQVEEEMLQDNTKS--SAQPENLIPMWSSD----IVTGEKNEPVK-PLQP 446
            .|  .|.:|  |..::.|..|.:....:.  :...|..:.:|.:.    :..|...:..| |.:.
  Fly   544 NY--HSPKL--IARLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQKI 604

Human   447 LIKEQKPKDQSLALSPKLECSGTILAHSNLRLLGSSD-SPASASRVAGIT 495
            |:...|.|...:...|  :.|..:.|:..|.:.||:| :.....|.|.||
  Fly   605 LLSHVKTKPSKIYCGP--DTSAVLFANGELHVCGSNDYNKLGFQRSAKIT 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEK4	XP_016862574.1	None
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	105/256 (41%)
		S_TKc	105..354	CDD:214567	104/250 (42%)
		ATS1	445..747	CDD:227511	47/225 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X891
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820