Protein Alignment STIM1 and stim1a

DIOPT Version :10

• Sequence 1: NP_001264890.1
• Gene: STIM1 / 6786
• HGNCID: 11386
• Length: 791
• Species: Homo sapiens
• Sequence 2: XP_005173449.1
• Gene: stim1a / 556360
• ZFINID: ZDB-GENE-060503-914
• Length: 808
• Species: Danio rerio
• Alignment Length: 821
• Identity: 477/821 - (58%)
• Similarity: 573/821 - (69%)
• Gaps: 82/821 - (9%)

Human    23 LSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDVEE 87
            |....::|....::.....::..:|.||||:|||..|:..|||||:|:|||.||||.||:|||.|
Zfish    17 LLQCRADKLNPVNTDPLPADNGVSELCRIDEPLCQDENAILSFEAIRSIHKQMDDDDNGNVDVLE 81

Human    88 SDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEE 152
            :|.|||||||||||..||:||||:|:.|||||||.||||||||||||||||:|||.||||.||.|
Zfish    82 TDGFLREDLNYHDPKGKHNTFHGDDQFISVEDLWNAWKSSEVYNWTVDEVVKWLIDYVELTQYVE 146

Human   153 TFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLV 217
            ..:||..||.|||||||.|.|:|.||||:.||||.||||||||||||||.|::.|||||||||||
Zfish   147 AIKKLNFSGTAMPRLAVKNNTLTQTVLKILDRSHVQKLQLKALDTVLFGAPMMNRHNHLKDFMLV 211

Human   218 VSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHL 282
            ||||||:|||||||||||:||:|||||||||:.|.||||||||||::|..||||||:||||||:|
Zfish   212 VSIVIGMGGCWFAYIQNRHSKDHMKKMMKDLDSLQRAEQSLHDLQQKLQIAQEEHRSVEVEKVNL 276

Human   283 EKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEAL 347
            |:|||||||.||||||||||||||||||.||||||||||||||.||:||||||||.|||..||||
Zfish   277 EQKLRDEINTAKQEAQRLKELREGTENELSRQKYAEEELEQVRMALKKAEKELESRSSWSPPEAL 341

Human   348 QKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTA 412
            |||||||||||||||||||||||:||.||||||||||||||||||||||||||||||||||||.|
Zfish   342 QKWLQLTHEVEVQYYNIKKQNAERQLQVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILAA 406

Human   413 KQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPAHFIMTDDV 477
            ||||.|||||||||||||||||:|.||.:|:|||:.||.:|||:|||:||. |..|.|| |:||:
Zfish   407 KQALGEVTAALRERLHRWQQIELLTGFTLVHNPGLPSLASALNLDPSFMGG-RGTPQHF-MSDDM 469

Human   478 DDMDEEIVSPLSMQ---------------------------SPSLQSSVRQRLTEPQHGLGSQRL 515
            |||||:||.|.::|                           :||:. |:|||..:||..||||||
Zfish   470 DDMDEDIVPPGTLQYAAWLMGRRASDLWSLNSDCQSFWKNSAPSMM-SLRQRHIDPQMALGSQRL 533

Human   516 V---------EGEAGHFLTS--RVSLRRMRSLSSGQSFSSEGYGTSSPSASAAASCSSSITTITT 569
            |         ||| |...:|  |.::|:.||.|.|| |.:.|....|.:.|..|..|:|.:.|..
Zfish   534 VESCLALGGQEGE-GSLYSSRPRTAMRQARSQSFGQ-FEALGLPPLSSAMSHPAIYSASSSHIPH 596

Human   570 TTTTTTTFTTVHVHPVYYHHSTSYFLQMEPYPDTPPSDSTAVMPGHSESLGDLTHSDSESSLHMS 634
            :       ::|..|..:||  :|:|..|:..||. |.|::...|.|..|.|||..|||:|||.:|
Zfish   597 S-------SSVAPHASHYH--SSHFQPMDTIPDL-PYDASPERPRHCGSHGDLNRSDSDSSLCIS 651

Human   635 ---DRQRVA-------PKPPQM-----SRAADEALNAMTSNGSHRLIEGVHPGSLVEKLPDSPAL 684
               ::.|::       .||..:     || ::|...:.|.||.:|:.:|   |...:.:||||.|
Zfish   652 QTGEQLRLSYSSKGFPVKPTSLLHGPHSR-SEEGAQSHTHNGGNRVHDG---GPSPDGVPDSPIL 712

Human   685 AKKALLALNHGLDKAHSLMELSPSAPPGGSPHLDSSRSHSPSSPDPDTPSPVGDSRALQASRNTR 749
            .||.     :|::|:.|:.|:..|  .......:||||.||:|.:||||||.|   ........|
Zfish   713 MKKL-----YGIEKSASMSEIHGS--QAAMSMSESSRSLSPNSTEPDTPSPTG---LTGGKAGNR 767

Human   750 IPHLAGKKAVAEEDNGSIGEETDSSPGRKKFPLKIFKKPLK 790
            ||.::.||:..|||:||.||:|||:..|||...|||||..|
Zfish   768 IPQISSKKSPLEEDSGSTGEDTDSAASRKKHTFKIFKKQKK 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STIM1	NP_001264890.1	SAM_STIM1	128..201	CDD:188972	55/72 (76%)
		DR0291	244..>427	CDD:441187	161/182 (88%)
		SOAR	342..441	CDD:465164	90/98 (92%)
		SOAR/CAD. /evidence=ECO:0000269|PubMed:19182790	344..442		90/97 (93%)
		Contributes to fast Ca(2+)-dependent inactivation of CRAC channels. /evidence=ECO:0000269|PubMed:19706554	475..483		6/7 (86%)
stim1a	XP_005173449.1	SAM_STIM1	122..195	CDD:188972	55/72 (76%)
		DR0291	238..>421	CDD:441187	161/182 (88%)
		SOAR	336..435	CDD:465164	90/98 (92%)