Protein Alignment STIM1 and stim1

DIOPT Version :10

• Sequence 1: NP_001264890.1
• Gene: STIM1 / 6786
• HGNCID: 11386
• Length: 791
• Species: Homo sapiens
• Sequence 2: XP_031751683.1
• Gene: stim1 / 403095
• XenbaseID: XB-GENE-947969
• Length: 771
• Species: Xenopus tropicalis
• Alignment Length: 817
• Identity: 554/817 - (67%)
• Similarity: 622/817 - (76%)
• Gaps: 76/817 - (9%)

Human     3 VCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEA 67
            :|.|..||.|....|..|:  :||.:|.|        .|:....|||||||.|||:.||.|||||
 Frog     2 LCCRTLLWALCASFLQPGR--THSPTETA--------PEDPILIEFCRIDKVLCHNADELLSFEA 56

Human    68 VRNIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNW 132
            |.:|||.|||||||:||||||||||||||||||||.||||||||||||||||||.:||:||||||
 Frog    57 VMSIHKQMDDDANGNVDVEESDEFLREDLNYHDPTAKHSTFHGEDKLISVEDLWNSWKTSEVYNW 121

Human   133 TVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDT 197
            |||||.|||||||||||||||||||||||..|||||:.|.|||||:|||||||.|||||||||||
 Frog   122 TVDEVAQWLITYVELPQYEETFRKLQLSGRDMPRLAIANATMTGTLLKMTDRSQRQKLQLKALDT 186

Human   198 VLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQ 262
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
 Frog   187 VLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKDHMKKMMKDLEGLHRAEQSLHDLQ 251

Human   263 ERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREA 327
            |||.||||||||||||||||||||::||:||||||.||:|||||||||.|||||||:||||||.|
 Frog   252 ERLQKAQEEHRTVEVEKVHLEKKLQNEISLAKQEAHRLRELREGTENELSRQKYAEQELEQVRMA 316

Human   328 LRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFG 392
            |:.|||||||||:|.||||||||||||||||||||||||||||||||:|||||||||||||||||
 Frog   317 LKNAEKELESHSNWSAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLLAKEGAEKIKKKRNTLFG 381

Human   393 TFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNID 457
            ||||||||||||||||||||||||||||||||||||||||||.|||||||||||:|:|:||||||
 Frog   382 TFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIETLCGFQIVNNPGLHALMAALNID 446

Human   458 PSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQHGLGSQRLVEG---- 518
            ||.||.:||.|.||||:||:||:||||:||::||||:| ||:|||..:.|..|||||||||
 Frog   447 PSLMGVSRPAPTHFIMSDDLDDLDEEIISPITMQSPNL-SSLRQRHVDSQLALGSQRLVEGYLVS 510

Human   519 --EAG---HFLTSRVSLRRMRSLSSGQSFSSEGYGTSSPSASAAASCSSSITTITTTTTTTTTFT 578
              ||.   |:..|:|||.||||||||||||||.:..:..||::.::|              ..|:
 Frog   511 QSEATPQIHYRPSKVSLHRMRSLSSGQSFSSEHHPGAVSSAASPSTC--------------PPFS 561

Human   579 T-------VHVHPVYYHHSTSYFLQMEPYPDTPPSDSTAVMPGHSESLGDLTHSDSESSLHMSDR 636
            |       .|.|||||||||:|::||:..||.|| |.|:.:|..|.|:|||:.|||||||.....
 Frog   562 TSPLPPPGPHSHPVYYHHSTTYYVQMDSLPDLPP-DVTSGIPCRSPSVGDLSRSDSESSLPYVTE 625

Human   637 QRVA------PKPPQMSRAADEALNAMTSNGSHRLIEGVHPGSLV-EKLPDSPALAKKALLALNH 694
            .|..      |....:.|..:|     |.||.:|.:|..:..:.. |.||:||.:.||.
 Frog   626 PRAGGHTSKIPSSKALPRTLEE-----TPNGGNRHLELANVSAAAQESLPESPQMGKKL------ 679

Human   695 GLDKAHSLMELSPSAPPGGSPHLDSSRSHSPSSPDPDTPSPVGDSRALQASRN------TRIPHL 753
             .:||.||.|:  ||......|.||||||||||.:.|||||       ::..|      ||||.|
 Frog   680 -SEKAPSLGEI--SAAGTAQSHSDSSRSHSPSSTEADTPSP-------ESKHNNSKGGGTRIPQL 734

Human   754 AGKKAVAEEDNGSIGEETDSSPGRKKFPLKIFKKPLK 790
            |||||.||:|:||.||:|||..|:||..|||||||.|
 Frog   735 AGKKAAAEDDSGSTGEDTDSLTGKKKLTLKIFKKPKK 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STIM1	NP_001264890.1	SAM_STIM1	128..201	CDD:188972	64/72 (89%)
		DR0291	244..>427	CDD:441187	168/182 (92%)
		SOAR	342..441	CDD:465164	95/98 (97%)
		SOAR/CAD. /evidence=ECO:0000269|PubMed:19182790	344..442		95/97 (98%)
		Contributes to fast Ca(2+)-dependent inactivation of CRAC channels. /evidence=ECO:0000269|PubMed:19706554	475..483		5/7 (71%)
stim1	XP_031751683.1	SAM_STIM1	117..190	CDD:188972	64/72 (89%)
		DR0291	233..>416	CDD:441187	168/182 (92%)
		SOAR	331..430	CDD:465164	95/98 (97%)