Protein Alignment STIM1 and Stim

DIOPT Version :10

• Sequence 1: NP_001264890.1
• Gene: STIM1 / 6786
• HGNCID: 11386
• Length: 791
• Species: Homo sapiens
• Sequence 2: NP_523357.2
• Gene: Stim / 32556
• FlyBaseID: FBgn0045073
• Length: 570
• Species: Drosophila melanogaster
• Alignment Length: 527
• Identity: 203/527 - (38%)
• Similarity: 299/527 - (56%)
• Gaps: 72/527 - (13%)

Human    20 GQSLSHSHSEKAT---GTSSGANSEEST----------------------AAEF----------- 48
            ||||.:|.||..|   .:.:|:..|.||                      :.||
  Fly    61 GQSLHNSQSEHVTHIAASHAGSGGEHSTHLAQNLHRSSYNLLSEAMSQAVSNEFSSMGSGSADGA 125

Human    49 CRIDKPLCH--SEDEKLSFEAVRNIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVK-HSTFH- 109
            |..|...|:  |..::...||:.::|:.:|||.||::|:.|||:||||:|.|.....| ...||
  Fly   126 CAADDFDCYSGSVQDRFGMEAIASLHRQLDDDDNGNIDLSESDDFLREELKYDSGYEKRQKAFHF 190

Human   110 GEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTM 174
            .:|..|||::||:||..|||:|||:::...||...|:||||.:.|:..:::|.|:|||||.|...
  Fly   191 NDDMHISVKELWEAWLRSEVHNWTIEQTTDWLAQSVQLPQYVDLFKLHKVTGAALPRLAVNNLQY 255

Human   175 TGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKE 239
            .|.||.:.|..|:||:.|||:|.||||||..| ....||::||..::..:.|||:||.||:.:|.
  Fly   256 VGNVLGIKDPIHKQKISLKAMDVVLFGPPRET-GTRWKDYILVTLLLSAIIGCWYAYQQNKNAKR 319

Human   240 HMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQ----EAQRL 300
            |:::|.:|:|||.||||||.::|:.|.:|:.|...|..||:.||::|::...|:..    |.|:|
  Fly   320 HLRRMAQDMEGLQRAEQSLQEMQKELERARMEQENVATEKLDLERRLKEAPTLSSSNSDLEVQQL 384

Human   301 KELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIK 365
            |                 :|:|.:|..|.:||.||.. :.|..|..||.|||.|:|:|.:.:..|
  Fly   385 K-----------------KEIEMLRNELSRAEFELVD-NCWSPPPQLQSWLQYTYELESKNHQKK 431

Human   366 KQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRW 430
            :.:|||||..|:|..||::|||::|.|.|...|..|:||||..|:.|:.||.:||..|:||||||
  Fly   432 RTSAEKQLQSAREACEKLRKKRSSLVGAFVSTHGKSIDDVDRSIVEARNALGDVTNELQERLHRW 496

Human   431 QQIEILCGFQIVNNPGIHSLVAAL-----NIDPSW-MGSTRPNPAHFIMTDDVDDMDEE-IVSPL 488
            :|||...|..||||.|:..|...|     .:..|. |.||:.:.|.  :|:..:|:|:| |...|
  Fly   497 KQIETCLGLNIVNNNGLPYLENVLYGRNGGLQSSMGMSSTKGSRAR--ITNSTEDLDDESIQGKL 559

Human   489 SMQSPSL 495
            :.::.||
  Fly   560 NFENFSL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STIM1	NP_001264890.1	SAM_STIM1	128..201	CDD:188972	34/72 (47%)
		DR0291	244..>427	CDD:441187	74/186 (40%)
		SOAR	342..441	CDD:465164	48/98 (49%)
		SOAR/CAD. /evidence=ECO:0000269|PubMed:19182790	344..442		48/97 (49%)
		Contributes to fast Ca(2+)-dependent inactivation of CRAC channels. /evidence=ECO:0000269|PubMed:19706554	475..483		2/7 (29%)
Stim	NP_523357.2	SAM_STIM-1,2-like	209..282	CDD:188903	34/72 (47%)
		YhaN	312..>501	CDD:443752	85/206 (41%)
		SOAR	408..507	CDD:465164	48/98 (49%)