DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ntm and DIP-delta

DIOPT Version :9

Sequence 1:	XP_021334871.1	Gene:	ntm / 678534	ZFINID:	ZDB-GENE-060421-6020	Length:	380	Species:	Danio rerio
Sequence 2:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	388	Identity:	99/388 - (25%)
Similarity:	168/388 - (43%)	Gaps:	59/388 - (15%)

- Green bases have known domain annotations that are detailed below.

Zfish    18 RLLFLL-PAGLPVRSQGESQSDNKQMDNITIRQGETLFLSCSQGDFVTH-----TAW--LNRSSI 74
            |::||: ...|......:.....:.:.|:|:..|....|.|    .|.|     .||  ::|..|
  Fly    25 RIMFLIYMTNLVTHVMMDEPRFAQPIPNVTVAVGRDANLPC----VVEHLGGYKVAWIHIDRQMI 85

Zfish    75 LYAGEDKWSVDPRVSLVTLSQEEFTIKIEDVDVTDEGQYICAVQTSSRPRTTSV-HIIVQVPPKI 138
            |.......|..||.| :|.:...:.:.:......|.|.|:|.|.|:  |..:.| ::.|.|||.|
  Fly    86 LTIHRHVISRIPRYS-ITYTDNTWLLHVNQAHQDDRGYYMCQVNTN--PMISQVGYLQVVVPPNI 147

Zfish   139 VNLS---RDLVVNEGSNVTLMCLANGKPEPAIVWRMKSPSDDSLSS-------DSEVLDIPFISR 193
            :::.   ..:.|.|..|:.:.|.|:|.|.|.|:||.:...:.::..       |::||.:..:||
  Fly   148 LDIESTPSSVAVRENQNINMTCRADGFPAPKIIWRREDGEEIAVEKKKKVLVYDADVLPLTKVSR 212

Zfish   194 YRAGVYECTAANDIAVD-TQTVELTVNYAPSV-SDGRDVGVTLGQRGVLQCEADAVPEADFEWYR 256
            ...|.|.|.|.|.:... ::.:.|.|.::|.: ...:.||...|....:.|..:|.|:|...|
  Fly   213 NEMGAYLCIATNGVPPSVSKRIILDVEFSPMIWVPNQLVGAPSGTDVTIDCHTEAHPKAIIYW-- 275

Zfish   257 DDRRIFNGL----------DGIEIEAAGALSRLTFFNVSEADYGNYTCVAINKLGSANTSFVLYE 311
                ::|.:          |..| .:..|..:||..|:...|:|||.|::.|.||....|..:||
  Fly   276 ----VYNSVMVLPSKKYKTDYTE-NSYRAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVYE 335

Zfish   312 IIEPTSSTLLQVETS---------PSVLEMTSSDLEQT---PLQNDLWEGPGAVQDGNSGTST 362
            |..|::.:.....|:         ||....|:..|:..   .::|||:  ||:....:||.|:
  Fly   336 IPLPSTPSKQVTHTTVESRENNIIPSSRNDTTKSLQTDVGYAMKNDLY--PGSASSSSSGGSS 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ntm	XP_021334871.1	Ig	44..132	CDD:325142	25/95 (26%)
		Ig_3	135..205	CDD:316449	23/79 (29%)
		I-set	228..309	CDD:333254	24/90 (27%)
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	26/98 (27%)
		Ig	145..238	CDD:416386	24/92 (26%)
		Ig strand A	145..149	CDD:409353	2/3 (67%)
		Ig strand A'	154..159	CDD:409353	0/4 (0%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	2/5 (40%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	1/7 (14%)
		Ig	242..333	CDD:416386	25/97 (26%)
		Ig strand A'	250..253	CDD:409353	1/2 (50%)
		Ig strand B	259..266	CDD:409353	1/6 (17%)
		Ig strand C	272..277	CDD:409353	1/10 (10%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	1/3 (33%)
		Ig strand E	295..305	CDD:409353	2/9 (22%)
		Ig strand F	314..322	CDD:409353	4/7 (57%)
		Ig strand G	325..334	CDD:409353	2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4644
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.970