DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ELOVL4 and CG31522

DIOPT Version :9

Sequence 1:	NP_073563.1	Gene:	ELOVL4 / 6785	HGNCID:	14415	Length:	314	Species:	Homo sapiens
Sequence 2:	NP_001262254.1	Gene:	CG31522 / 40567	FlyBaseID:	FBgn0051522	Length:	392	Species:	Drosophila melanogaster

Alignment Length:	297	Identity:	117/297 - (39%)
Similarity:	169/297 - (56%)	Gaps:	29/297 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    27 RWTWSIADKRVENWPLMQSPWPTLSISTLYLLFV-WLGPKWMKDREPFQMRLVLIIYNFGMVLLN 90
            |:..|.:|.|.:.||:|.||:|||::...|:..| .|||:.|::|:|..::..|::||...|:.:
  Fly    13 RYMDSHSDSRTKGWPMMSSPFPTLAVCLTYVYLVKVLGPRLMENRKPLNLQNTLVMYNAIQVVFS 77

Human    91 LFIFRELFM----GSYN------------------------AGYSYICQSVDYSNNVHEVRIAAA 127
            .::|.|..|    |||:                        ..||:.||.||||||...:|:..|
  Fly    78 AWLFYECLMGGWWGSYSFRCQPVDYTDSPTSRRIGISGWLTGHYSFRCQPVDYSNNPRTLRMVHA 142

Human   128 LWWYFVSKGVEYLDTVFFILRKKNNQVSFLHVYHHCTMFTLWWIGIKWVAGGQAFFGAQLNSFIH 192
            .|||:.||..|::||:||:||||::||:.|||.||..|....|.|:|:..||.:.|...||:|:|
  Fly   143 CWWYYFSKFTEFMDTIFFVLRKKSSQVTTLHVIHHGCMPMSVWFGVKFTPGGHSTFFGLLNTFVH 207

Human   193 VIMYSYYGLTAFGPWIQKYLWWKRYLTMLQLIQFHVTIGHTALSLYTDCPFPKWMHWALIAYAIS 257
            ::||:||..:|.||..|||||||:|||.||::||.:.:.|....|:.||.:||...|.:..:|:.
  Fly   208 IVMYTYYMFSAMGPQYQKYLWWKKYLTTLQMVQFILIMVHAFQLLFIDCNYPKAFVWWIGMHAVM 272

Human   258 FIFLFLNFYIRTYKEPKKPKAGKTAMNGISANGVSKS 294
            |.|||..||...|:.....|.|..|......||..||
  Fly   273 FFFLFNEFYKAAYRSRMMKKNGALANGHAKPNGYCKS 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ELOVL4	NP_073563.1	ELO	41..278	CDD:279492	105/265 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..314		7/20 (35%)
		Di-lysine motif. /evidence=ECO:0000255\|HAMAP-Rule:MF_03204	310..314
CG31522	NP_001262254.1	ELO	27..293	CDD:279492	105/265 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3071
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1094172at2759
OrthoFinder	1	1.000	-	-		FOG0000078
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R389
SonicParanoid	1	1.000	-	-		X54
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850