Protein Alignment HSPA13 and Hsc70-2

DIOPT Version :10

• Sequence 1: NP_008879.3
• Gene: HSPA13 / 6782
• HGNCID: 11375
• Length: 471
• Species: Homo sapiens
• Sequence 2: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Alignment Length: 698
• Identity: 143/698 - (20%)
• Similarity: 248/698 - (35%)
• Gaps: 227/698 - (32%)

Human   303 KKILDGKAVEIGTSLSK---------MTNQHACKLGANILLETFKIHEMIRQEILEQVLNRVVTR 358
            |:::|.:.:....:::|         |.......:.||..|..       |.::|:|.:.:|..|
  Fly    47 KRLMDAETLNSSLTINKAELKKKIVDMEKGQRPMIDANRKLSD-------RNKVLQQEVKKVEQR 104

Human   359 TSSPINHFLDLFSDIIMYAPLILQN-CSKVTETFDYLTFLPLQTVQGLLKAVQPLLKISMSMRDS 422
            .|...:.||.| .||  :..|:.:| |.|.                   |.|.|.....:|...:
  Fly   105 FSHSRDDFLTL-KDI--HERLLKENACLKE-------------------KRVSPEKLEELSRYRN 147

Human   423 LILVLRKAMFASQLDARKSAV---AGFLLLLKNFKVL-----------------GSLPSSQCTQS 467
            .:|...|.:.|    .|.||.   ..:.:|::.||.|                 ||..|:..|.|
  Fly   148 KVLEYSKCITA----LRSSAYEKDKRYEMLVQKFKRLQKCLKKSENDDDRMSNGGSDCSAASTVS 208

Human   468 IG-VTQ---------VRVDVHSRY-----------------SAVANETFCLEIIDSLKRSLGQQA 505
            :. :|:         :..|..:.|                 |.::.|:|..:.|.....::.||.
  Fly   209 LDTITEDFEEVFAKDIETDYQALYRENAELQRALNELQLNTSDLSEESFLRDQISFANSTIEQQQ 273

Human   506 DIRLMLYDGFYDVLRRNSQLASSI---------MQTLFSQLKQFYEPEPDLLPPLKLGACVLTQG 561
                ::.|...|::.:.:||.|:|         ::|....|||
  Fly   274 ----LVIDATQDMMSQTAQLKSTIAGQQEHIRSLETTVDDLKQ---------------------- 312

Human   562 SQIFLQEPLDHLLSCIQHCLAWYKSRVVPLQQGDEG-----------EEEEEELYSELDDM---- 611
             ||..|...:.:|          :.:|:.:::..:.           |.|:.:|..|||::
  Fly   313 -QIASQTERNDVL----------EFQVLEMEENQKQQDTIAAKQSTFESEKTQLLKELDEVKKAH 366

Human   612 ---LESITVRMIKSELEDFELDKSADFSQNTNVGIKNNICACLIMGVCEVLMEYNFSISNFSKSK 673
               |:||.  :||.||||   .|:|..|....:.....:.|  :....|.....|.||:
  Fly   367 ANQLKSIA--LIKKELED---HKAAAPSVKPTLSESEQVDA--LQQKFEKAEAANVSIN------ 418

Human   674 FEEILSLFTCYKKFSDILSEKAGKGKAKMTSKVSDSLLSLKFVSDLLTALFRDSIQSHEESLSVL 738
             ||:.|           .|::.||.:.:|..|.|| |...:.:::.|:|..:..:.|.:|  ..|
  Fly   419 -EELRS-----------ASKELGKIRFQMQGKESD-LSRERKMTEALSAQLQSVVSSSQE--EAL 468

Human   739 RSSGEFMHYAVNVTLQKIQQLIRTGHVSGPDGQNPDKIFQNL------------CDITRVLLWRY 791
            :...|.......|.||:.:  |...|   .|.:..|:.|:||            .:|...|..||
  Fly   469 KKEEELKKLKATVELQQAE--IEKMH---EDKKEADQKFKNLEKEYAAYRDEQRPEIKTELERRY 528

Human   792 TS----IPTSVE---------ESGKK-EKGKSISLLCLEGLQKTFSVVLQFYQPKVQQFLQALDV 842
            ..    :..::|         |:.|| |...|||    :.|::....|.:|.....:||....|:
  Fly   529 EEAKYRLKNALEKIHDYELLYEAAKKSENDGSIS----KHLEEELIEVKEFNAHLERQFQSQSDI 589

Human   843 MGTEEEEAGVTVTQRASFQIRQFQRSLLNLLSSEEDDFNSKEALLLIA 890
                     :...::...|.|.| ...:|.||..||....:|.|::.:
  Fly   590 ---------IEALKKKLLQHRSF-CDKINKLSELEDASRIQEELVMFS 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA13	NP_008879.3	ASKHA_NBD_HSP70_HSPA13	10..452	CDD:466835	33/161 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..352		8/45 (18%)
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	143/698 (20%)