DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment STAT5B and Stat92E

DIOPT Version :9

Sequence 1:NP_036580.2 Gene:STAT5B / 6777 HGNCID:11367 Length:787 Species:Homo sapiens
Sequence 2:NP_001262760.1 Gene:Stat92E / 42428 FlyBaseID:FBgn0016917 Length:818 Species:Drosophila melanogaster


Alignment Length:866 Identity:277/866 - (31%)
Similarity:413/866 - (47%) Gaps:170/866 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAVW------IQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIK--A 57
            |::|      :..:|       :|.|.|.:...:|:|..|:.|||.:........|..:.::  |
  Fly     1 MSLWKRISSHVDCEQ-------RMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVA 58

Human    58 TQLLEGLVQEL--QKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV 120
            .:..|.|.|:|  .:.|..|.      ||.::......:|..   ..:||...:|..|..|.:||
  Fly    59 LKFNEDLQQKLLSTRTASDQA------LKFRVVELCALIQRI---SAVELYTHLRSGLQKELQLV 114

Human   121 REANNGSSPAGSLADAMSQKHLQINQT---------FEELRLVTQDTE-------NELKKLQQT- 168
            .|    .|.|.:...:|......:|.|         ..:|..|:....       ..:..:|.| 
  Fly   115 TE----KSVAATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTG 175

Human   169 ------------QEYFIIQYQ--ESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREA 219
                        .|.:.:|:|  :||.   :||..|.       :.:...|.....|.:.....|
  Fly   176 IASPALGMVTPKVELYEVQHQIMQSLN---EFGNCAN-------ALKLLAQNYSYMLNSTSSPNA 230

Human   220 QTLQQYRVELAEKHQKTLQLLRK-------QQTIILDDELIQWKRRQQLAGNGGP-PEGSLDVLQ 276
            :.  .||..:.||....|.:.|.       .:.:|  .||..|:.:|..||||.| .|||||.:|
  Fly   231 EA--AYRSLIDEKAAIVLTMRRSFMYYESLHEMVI--HELKNWRHQQAQAGNGAPFNEGSLDDIQ 291

Human   277 SWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEML--------AEVNATITDIISA---LVTS 330
            ...|.|...|          .|:.      ..|:|::        .|:...:..:.:|   ||.|
  Fly   292 RCFEMLESFI----------AHML------AAVKELMRVRLVTEEPELTHLLEQVQNAQKNLVCS 340

Human   331 TFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRND---- 391
            .||::||||||:||.|:|||:||.|:|.:|.:|.|||.|:..|:||.|::..: ..||:.|    
  Fly   341 AFIVDKQPPQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFV-TRNTQMDNSSL 404

Human   392 ---YSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFESQFSVGGN 453
               .||||.|....|||.|.....||.||||.||:|||::::|.|||.:|||.:.|.:..:|  |
  Fly   405 SGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIKRAEKKGTESVMDEKFALFFYTTTTV--N 467

Human   454 ELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAE 518
            :...:|.||||||||||||:|:..:.||:.|||||||..|.||.:.|:|.|.||..|||:||.: 
  Fly   468 DFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWAQLSVALNIKFGS- 531

Human   519 VQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKK 583
             .:.|.||.:||.||.:||.....|   :|    ::|:||.:|.:|.|::|||:||..:|::.|.
  Fly   532 -CTGRSLTIDNLDFLYEKLQREERS---EY----ITWNQFCKEPMPDRSFTFWEWFFAIMKLTKD 588

Human   584 HLKPHWNDGAILGFVNKQQAH-DLLINKPD-GTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPF 646
            |:...|..|.|:||:||.:|. |||.:... |||||||||||:||:|||  :.::..:...|.|:
  Fly   589 HMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIA--YVNENGLVTMLAPW 651

Human   647 TTRDFSIRSLADRLGDLNYLIYVFP-DR-----PKD----EVYSKYYTPVPCESATAKAVDGYVK 701
            |.|||.:.:||||:.||:.|.::.| ||     .:|    |.|||...|.|   .....|.||||
  Fly   652 TARDFQVLNLADRIRDLDVLCWLHPSDRNASPVKRDVAFGEFYSKRQEPEP---LVLDPVTGYVK 713

Human   702 PQIKQVVPEFVNASADAGGGSATYMDQAPSPA--------VCPQAHYNMYPQNPDSVLDTDGDFD 758
            ..:      .|:...:...||.:   ..|..|        :.||:....|  :|..:.::|.  |
  Fly   714 STL------HVHVCRNGENGSTS---GTPHHAQESMQLGNISPQSGITFY--SPARLEESDS--D 765

Human   759 LEDTMDVARRVEELLG-RPMD 778
            ..:|.:...|:  ::| :|.|
  Fly   766 ASETAEALERI--VIGAQPND 784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
STAT5BNP_036580.2 STAT_int 2..124 CDD:308484 30/131 (23%)
STAT_alpha 141..330 CDD:307245 49/238 (21%)
Required for interaction with NMI. /evidence=ECO:0000269|PubMed:9989503 232..321 26/104 (25%)
STAT_bind 332..582 CDD:308483 120/256 (47%)
SH2_STAT5b 573..717 CDD:198283 61/155 (39%)
Stat92ENP_001262760.1 STAT_int 2..119 CDD:214942 30/136 (22%)
STAT_alpha 151..340 CDD:279369 46/218 (21%)
STAT_bind 342..587 CDD:280939 120/256 (47%)
SH2_STAT_family 578..696 CDD:198175 51/119 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146380
Domainoid 1 1.000 124 1.000 Domainoid score I5544
eggNOG 1 0.900 - - E1_KOG3667
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 317 1.000 Inparanoid score I2548
Isobase 1 0.950 - 0 Normalized mean entropy S6183
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D166575at33208
OrthoFinder 1 1.000 - - FOG0001643
OrthoInspector 1 1.000 - - otm40793
orthoMCL 1 0.900 - - OOG6_104819
Panther 1 1.100 - - LDO PTHR11801
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2821
SonicParanoid 1 1.000 - - X1200
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.740

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