Protein Alignment STAT4 and Stat92E

DIOPT Version :10

• Sequence 1: XP_054199536.1
• Gene: STAT4 / 6775
• HGNCID: 11365
• Length: 757
• Species: Homo sapiens
• Sequence 2: NP_001262760.1
• Gene: Stat92E / 42428
• FlyBaseID: FBgn0016917
• Length: 818
• Species: Drosophila melanogaster
• Alignment Length: 822
• Identity: 218/822 - (26%)
• Similarity: 361/822 - (43%)
• Gaps: 163/822 - (19%)

Human    10 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQ--------------DWEAASNNET 60
            ||.|.::.. .:...:::..:|::...:|:|..||.|||::              :..|...||.
  Fly     1 MSLWKRISS-HVDCEQRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVALKFNED 64

Human    61 MATILLQN----------LLIQLDEQLGRVSK-----------EKNLLLIHNLKRIRKVLQGKFH 104
            :...||..          .:::|...:.|:|.           :|.|.|:.. |.:.........
  Fly    65 LQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTE-KSVAATAGQSMP 128

Human   105 GNP--MHVAVVISNCLREERRILAAANM---PVQ---GPLEKSLQSSSVSERQRNVEHKVAAIKN 161
            .||  |:...:::..:.:...:||.:|.   ||.   ||:.....:...|.....|..||...:.
  Fly   129 LNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPALGMVTPKVELYEV 193

Human   162 SVQMTEQDTKY------LEDLQDEFDYRYKTIQTMDQSDKNSAMVNQE---VLTLQEMLNSLDFK 217
            ..|:.:...::      |:.|...:.|...:..:.:......::::::   |||::.     .|.
  Fly   194 QHQIMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRSLIDEKAAIVLTMRR-----SFM 253

Human   218 RKEALSKMTQIIHETDLLMNTMLIEELQDWKRRQQIACIGGPLHNG-LDQLQNCFTLLAESLFQL 281
            ..|:|       ||       |:|.||::|:.:|..|..|.|.:.| ||.:|.||.:|...:..:
  Fly   254 YYESL-------HE-------MVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLESFIAHM 304

Human   282 RRQLEKLEEQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTL 346
            ...:::|  ...::..| :|   :.||:||:|.....||..::|:|::||        |.|:||.
  Fly   305 LAAVKEL--MRVRLVTE-EP---ELTHLLEQVQNAQKNLVCSAFIVDKQP--------PQVMKTN 355

Human   347 IQFTVKLRLLI--KLPELNYQVKVKASIDKNVSTLSNRRFVLCGTNVKAMSIEESSNGSL----- 404
            .:|...:|.||  :|...|....|:..|   :|.:.::|||...|.:...|:...|:|.:
  Fly   356 TRFAASVRWLIGSQLGIHNNPPTVECII---MSEIQSQRFVTRNTQMDNSSLSGQSSGEIQNASS 417

Human   405 -----------SVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYGLTIDLETSSL 458
                       |..||::|.|::| .|..||.|.   |.:|..::.|.|...:....|.:.|.||
  Fly   418 TMEYQQNNHVFSASFRNMQLKKIK-RAEKKGTES---VMDEKFALFFYTTTTVNDFQIRVWTLSL 478

Human   459 PVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYVGRGLNSDQ 523
            |||:|.:.:|.|.:||:|.|.|......::.....:  ..|.:||...::.:|.|..||.|..|.
  Fly   479 PVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITD--RVTWAQLSVALNIKFGSCTGRSLTIDN 541

Human   524 LHMLAEKLTVQSSYSDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVS 588
            |..|.|||  |......::||.:||||.:|.:|||||.|..||:.|.|.|:|.:|..|.:|||::
  Fly   542 LDFLYEKL--QREERSEYITWNQFCKEPMPDRSFTFWEWFFAIMKLTKDHMLGMWKAGCIMGFIN 604

Human   589 KEKER--LLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADIL 651
            |.|.:  ||......||||||||:|.|||:|..:|  :|:|.|..  :.|:.......|..||.:
  Fly   605 KTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYV--NENGLVTM--LAPWTARDFQVLNLADRI 665

Human   652 RDYKVIMAENIPENPLKYLYPD------IPKDKAFGKHYSS----QPCEVSRPTERGDKGYVPSV 706
            ||..|          |.:|:|.      :.:|.|||:.||.    :|..:...|     |||.|.
  Fly   666 RDLDV----------LCWLHPSDRNASPVKRDVAFGEFYSKRQEPEPLVLDPVT-----GYVKST 715

Human   707 FIPISTIR-----SDSTEPHSPSDLLPMSPSVYAVLRENLSP 743
             :.:...|     |.|..||...:.:.:.         |:||
  Fly   716 -LHVHVCRNGENGSTSGTPHHAQESMQLG---------NISP 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STAT4	XP_054199536.1	STAT_int	11..130	CDD:214942	27/155 (17%)
		STAT4_CCD	149..321	CDD:341079	40/181 (22%)
		STAT4_DBD	325..482	CDD:341086	53/174 (30%)
		SH2_STAT4	562..709	CDD:198238	55/158 (35%)
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	22/118 (19%)
		STAT_CCD	191..338	CDD:341075	37/171 (22%)
		STAT_DBD	342..502	CDD:341082	53/174 (30%)
		SH2_STAT_family	578..696	CDD:198175	48/131 (37%)