Protein Alignment STAT3 and Stat92E

DIOPT Version :10

• Sequence 1: NP_644805.1
• Gene: STAT3 / 6774
• HGNCID: 11364
• Length: 770
• Species: Homo sapiens
• Sequence 2: NP_001262760.1
• Gene: Stat92E / 42428
• FlyBaseID: FBgn0016917
• Length: 818
• Species: Drosophila melanogaster
• Alignment Length: 857
• Identity: 208/857 - (24%)
• Similarity: 341/857 - (39%)
• Gaps: 205/857 - (23%)

Human     1 MAQWNQL-QQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEI 64
            |:.|.:: ..:|..  :::...|.:...:|||..||||||.:             ::...:....
  Fly     1 MSLWKRISSHVDCE--QRMAAYYEEKGMLELRLCLAPWIEDR-------------IMSEQITPNT 50

Human    65 DQQYSRFLQESNVLYQHNLRRIK----QFLQSRYLEKPMEIARIVARCLWEESR-------LLQT 118
            ..|..|...:.|...|..|...:    |.|:.|.:|....|.||.|..|:...|       .|.|
  Fly    51 TDQLERVALKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVT 115

Human   119 AATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDL-----------EQKMKVVENLQDD- 171
            ..:.|...|| :.|..........|:..::.|    ..||           .|.:..:.|:|:.
  Fly   116 EKSVAATAGQ-SMPLNPYNMNNTPMVTGYMVD----PSDLLAVSNSCNPPVVQGIGPIHNVQNTG 175

Human   172 ---------------FDFNYKTLKSQGDMQDLN--GNNQSVTRQKMQQLEQMLTA-----LDQMR 214
                           ::..::.      ||.||  ||..:..:...|....||.:     .:...
  Fly   176 IASPALGMVTPKVELYEVQHQI------MQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAY 234

Human   215 RSIVSELAGLLSAME----YVQK--TLTDEELADWKRRQQIACIGGPPN--------ICLDRLEN 265
            ||::.|.|.::..|.    |.:.  .:...||.:|:.:|..|..|.|.|        .|.:.||:
  Fly   235 RSLIDEKAAIVLTMRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLES 299

Human   266 WITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMP 330
            :|..:          :..::||.:......:|.:.|   |.|::....:||:.|||:|::||
  Fly   300 FIAHM----------LAAVKELMRVRLVTEEPELTH---LLEQVQNAQKNLVCSAFIVDKQP--- 348

Human   331 MHPDRPLVIKTGVQFTTKVRLLV------------------------KFPELNYQLKIKVCIDKD 371
                 |.|:||..:|...||.|:                        :|...|.|:.......:.
  Fly   349 -----PQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSLSGQS 408

Human   372 SGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEEL 436
            ||::.....:.::             :.||...||.|:::.|::.:     ||....:..|.:|.
  Fly   409 SGEIQNASSTMEY-------------QQNNHVFSASFRNMQLKKIK-----RAEKKGTESVMDEK 455

Human   437 HLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTW 501
            ..:.|.|.......:|.:.|.|||||||.:..|.|.:||:|.|.|......::....|...  ||
  Fly   456 FALFFYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRV--TW 518

Human   502 DQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQ-------ITWAKFCKENMAGKGF 559
            .|::..|:.:|.|.|.|.|:|:.|..|.|||          |       |||.:||||.|..:.|
  Fly   519 AQLSVALNIKFGSCTGRSLTIDNLDFLYEKL----------QREERSEYITWNQFCKEPMPDRSF 573

Human   560 SFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAIL--STKPPGTFLLRFSESSKEGGVTFT 622
            :||.|...|:.|.|.::|.:|..|.|||||:|.:.:..|  |....||||||||: |:.||||..
  Fly   574 TFWEWFFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSD-SELGGVTIA 637

Human   623 WVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPD------IPKEE 681
            :|.::    ..:..:.|:|.:....::.|:     :|.|     :..|.:|:|.      :.::.
  Fly   638 YVNEN----GLVTMLAPWTARDFQVLNLAD-----RIRD-----LDVLCWLHPSDRNASPVKRDV 688

Human   682 AFGK-YCRPESQEHPEADPGSAAPYLKTKF---ICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGE 742
            |||: |.:.:..|....||  ...|:|:..   :|......|.:    .:|......||.||
  Fly   689 AFGEFYSKRQEPEPLVLDP--VTGYVKSTLHVHVCRNGENGSTS----GTPHHAQESMQLGN--- 744

Human   743 GAEPSAGGQFES 754
             ..|.:|..|.|
  Fly   745 -ISPQSGITFYS 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STAT3	NP_644805.1	STAT_int	2..120	CDD:214942	29/129 (22%)
		STAT3_CCD	139..318	CDD:341078	42/226 (19%)
		Essential for nuclear import	150..162		4/22 (18%)
		STAT3_DBD	321..484	CDD:341085	45/186 (24%)
		SH2_STAT3	554..715	CDD:198237	51/172 (30%)
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	29/131 (22%)
		STAT_CCD	191..338	CDD:341075	34/165 (21%)
		STAT_DBD	342..502	CDD:341082	45/185 (24%)
		SH2_STAT_family	578..696	CDD:198175	41/132 (31%)