DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stx17 and Syx7

DIOPT Version :9

Sequence 1:	NP_080619.2	Gene:	Stx17 / 67727	MGIID:	1914977	Length:	301	Species:	Mus musculus
Sequence 2:	NP_730632.1	Gene:	Syx7 / 36173	FlyBaseID:	FBgn0267849	Length:	282	Species:	Drosophila melanogaster

Alignment Length:	273	Identity:	60/273 - (21%)
Similarity:	107/273 - (39%)	Gaps:	71/273 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse    18 QKFTKIVIPTDLERLRKHQINIEKYQRC-----------RIWDKLHEEHINAGRTVQQLRSNIRE 71
            |:..:|:..:    ::|.|.|:...||.           .:..:||:......:.|....:.|.|
  Fly    24 QRLAQIIATS----IQKVQQNVSTMQRMVNQLNTPQDSPELKKQLHQIMTYTNQLVTDTNNQINE 84

Mouse    72 MEKLC----LKVHKDDLVLLKRMIDPVKEAAATATAEFLQLHLESVEELKKQVNDEELLQP---- 128
            ::| |    ||:.:|      |::|   |..|..||      .:||:.....:....|.|.
  Fly    85 VDK-CKERHLKIQRD------RLVD---EFTAALTA------FQSVQRKTADIEKTALRQARGDS 133

Mouse   129 -SLTRSTTVDGVLHTGEA-EAASQ----------------SLTQIYALPEIPQDQNAAESWE--- 172
             ::.|.   .|...||.: .:|||                :..|:....|...|..|.|..|
  Fly   134 YNIARP---PGSSRTGSSNSSASQQDNNSFFEDNFFNRKSNQQQMQTQMEEQADLQALEEQEQVI 195

Mouse   173 -TLEADLIELSHLVTDMSLLVSSQQEKIDSIADHVNSAAVNVEEGTKNLQKAAKY-------KLA 229
             .||.:::.::.:...:..||..|...:|||...|...::.|.:||:||:||:.|       ||.
  Fly   196 RELENNIVGVNEIYKKLGALVYEQGLTVDSIESQVEQTSIFVSQGTENLRKASSYRNKVRKKKLI 260

Mouse   230 ALPVAGALIGGVV 242
            .:.:..|::..::
  Fly   261 LVGILSAVLLAII 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stx17	NP_080619.2	SNARE_syntaxin17	161..222	CDD:277199	18/64 (28%)
		Necessary and sufficient for localization to autophagosome. /evidence=ECO:0000250\|UniProtKB:P56962	228..274		2/15 (13%)
		Endoplasmic reticulum retention signal. /evidence=ECO:0000255	298..301
Syx7	NP_730632.1	Syntaxin_2	30..126	CDD:291208	23/115 (20%)
		COG5325	<97..276	CDD:227635	44/195 (23%)
		SNARE	188..247	CDD:304603	16/58 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900