Protein Alignment STAT1 and Stat92E

DIOPT Version :10

• Sequence 1: NP_001371820.1
• Gene: STAT1 / 6772
• HGNCID: 11362
• Length: 762
• Species: Homo sapiens
• Sequence 2: NP_001262760.1
• Gene: Stat92E / 42428
• FlyBaseID: FBgn0016917
• Length: 818
• Species: Drosophila melanogaster
• Alignment Length: 884
• Identity: 219/884 - (24%)
• Similarity: 371/884 - (41%)
• Gaps: 216/884 - (24%)

Human     1 MSQWYEL-QQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDCSRMKCVNVKSPREHAANDVSF 64
            ||.|..: ..:|.:  :::...|::...:|:|..||.|:|.:..|.....|.....|..|
  Fly     1 MSLWKRISSHVDCE--QRMAAYYEEKGMLELRLCLAPWIEDRIMSEQITPNTTDQLERVA----- 58

Human    65 ATIRFHDLLSQ-------LDDQYSRFS-LENNFLLQH--------NIRKS-KRNLQ--------- 103
              ::|::.|.|       ..||..:|. :|...|:|.        ::|.. ::.||
  Fly    59 --LKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVTEKSVAA 121

Human   104 -------------------DNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTV--M 147
                               ..:..||..:..:..||   ...:::.....:..|:..|.|..  |
  Fly   122 TAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSC---NPPVVQGIGPIHNVQNTGIASPALGM 183

Human   148 LDKQKELDSKVRNVKDKVMCIEHEI----KSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQ 208
            :..:.||    ..|:.::|...:|.    .:|:.|...|.:...:..:...|....:..|:|...
  Fly   184 VTPKVEL----YEVQHQIMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRSLIDEKAAI 244

Human   209 LL-LKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPN-ACLDQL 271
            :| :::.::..::..:.|:|                   ||..|:.:|..|..|.|.| ..||.:
  Fly   245 VLTMRRSFMYYESLHEMVIH-------------------ELKNWRHQQAQAGNGAPFNEGSLDDI 290

Human   272 QNWFTIVAESLQQVRQQLKKL-------EELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSF 329
            |..|.::...:..:...:|:|       ||.|..:..|.   .:|.|          :.|:.|:|
  Fly   291 QRCFEMLESFIAHMLAAVKELMRVRLVTEEPELTHLLEQ---VQNAQ----------KNLVCSAF 342

Human   330 VVERQPCMPTHPQRPLVLKTGVQFTVKLRLLV--KLQELNYNLKVKVLFDKDVNE-----RNT-- 385
            :|::||        |.|:||..:|...:|.|:  :|...|....|:.:...::..     |||
  Fly   343 IVDKQP--------PQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQM 399

Human   386 ----VKGFRKFNILGTHTKVMNME-ESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSL 445
                :.|.....|....:   .|| :..|...:|.||::|||:.|.|..:..|.   |.:|..:|
  Fly   400 DNSSLSGQSSGEIQNASS---TMEYQQNNHVFSASFRNMQLKKIKRAEKKGTES---VMDEKFAL 458

Human   446 SFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNM---LVAEPRNLSFFLTPPCARW 507
            .|.|........|.:.|.|||||||.:.:|.|..||:|.|.|.   :|.:|     |:......|
  Fly   459 FFYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDP-----FMITDRVTW 518

Human   508 AQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIES 572
            ||||..|:.:|.|.|.|.|.:|.|:.|.|||.....|.  .|.|.:||||.:.|::|.||.|..:
  Fly   519 AQLSVALNIKFGSCTGRSLTIDNLDFLYEKLQREERSE--YITWNQFCKEPMPDRSFTFWEWFFA 581

Human   573 ILELIKKHLLPLWNDGCIMGFISKERERA-LLKDQQP-GTFLLRFSESSREGAITFTWVERSQNG 635
            |::|.|.|:|.:|..|||||||:|.:.:. ||:.... ||||||||:|.. |.:|..:|  ::||
  Fly   582 IMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSEL-GGVTIAYV--NENG 643

Human   636 GEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPN------IDKDHAFGKYYS 694
               ....:.|:|.::...:...|.||:..|:.          :|:|:      :.:|.|||::||
  Fly   644 ---LVTMLAPWTARDFQVLNLADRIRDLDVLC----------WLHPSDRNASPVKRDVAFGEFYS 695

Human   695 RPKEAPEPMELDGPKGTGYIKTELISVSEVH---------------------------------- 725
            :.:| |||:.||  ..|||:|:.|    .||
  Fly   696 KRQE-PEPLVLD--PVTGYVKSTL----HVHVCRNGENGSTSGTPHHAQESMQLGNISPQSGITF 753

Human   726 --PSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV 762
              |:||:.:|:....:.|..:.:  ::|:...|.:::.:
  Fly   754 YSPARLEESDSDASETAEALERI--VIGAQPNDPVISEI 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STAT1	NP_001371820.1	STAT_int	2..133	CDD:214942	30/176 (17%)
		STAT1_CCD	150..325	CDD:341076	34/187 (18%)
		STAT1_DBD	329..489	CDD:341083	52/176 (30%)
		SH2_STAT1	569..719	CDD:198235	55/157 (35%)
		STAT1_TAZ2bind	727..751	CDD:432372	4/23 (17%)
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	26/125 (21%)
		STAT_CCD	191..338	CDD:341075	32/178 (18%)
		STAT_DBD	342..502	CDD:341082	52/173 (30%)
		SH2_STAT_family	578..696	CDD:198175	44/133 (33%)