DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kirrel3 and tutl

DIOPT Version :9

Sequence 1:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	911	Identity:	193/911 - (21%)
Similarity:	315/911 - (34%)	Gaps:	238/911 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse    54 PQDQV---VVSGQPVTLLCAIPEYDG-----FVL-WIKDGLALGVGRDL------SSYPQYLVVG 103
            |:|.|   .:.|:.|...|.: |:..     :|| |  |......|.||      .|||:::..|
  Fly   132 PEDAVHITAILGEGVIFNCHV-EFPNDHPVPYVLQW--DKKVSETGSDLPIYIWYESYPEHIEEG 193

Mouse   104 -----NHLS-----GEHHLKILRAELQDDAVYECQAIQAAIRSR-----------------PARL 141
                 :.:|     |...|.:......|...|||:.:   ..:|                 |.|.
  Fly   194 YKGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKVV---FLNRDPKQHKNGTWFHLDVHAPPRF 255

Mouse   142 TVLVPPDDPIILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRE 206
            :  |.|:|       :|.:..||.:.|.|.||.. |...|:|.:....::.:. :..:..|| .|
  Fly   256 S--VTPED-------IIYVNLGDSIILNCQADGT-PTPEILWYKDANPVDPSP-TVGIFNDG-TE 308

Mouse   207 SIVSTLFISPGDV-------ENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLED 264
            ..:||  |...|:       .||:..|.......|.||....|      ||      ..|..||.
  Fly   309 LRIST--IRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMV------PP------TNQTKLEG 359

Mouse   265 NIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTV--DYTYFSEPVS--------CEVTNA 319
            ..|.|.|.|||.|.....||.:.|..::|.:....|.|:  |.:....|:.        |||||.
  Fly   360 EKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNG 424

Mouse   320 LGS-TNLSRTVDVYFGPRMTSEPQSLLVDLGSDAVFSCAWIGNPSLT-IVWMK--------RGSG 374
            :|. .:.|..:.|.:..::|..|....:......|..|....:|.|. :.|.|        :...
  Fly   425 IGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTKDKRLLEPYQMKD 489

Mouse   375 VVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREV-TLTVNGPPIIS---STQTQHALHGEK 435
            :|:....:|....|.:|..|:|.|.....:..||...| .:.|..||..:   .|..|..: |:.
  Fly   490 IVVMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPETLYQRKV-GDS 553

Mouse   436 GQIKCFIRSTPPPDRIAWSWK----ENVLESG------TSGRYTVETVNTEEGVISTLTISNIV- 489
            .::.|........:|....|:    |.:.||.      :.|..|:|.:..|:.......:||.|
  Fly   554 VEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKISGGNITIENLRREDFGYYQCVVSNEVA 618

Mouse   490 --RADFQTIYNCT----AWNSFGSDTE-IIRLK-----EQGSEMKSG-------AGL---EAESV 532
              .|..|.:...|    .:|..|..|| .|.|:     ..|||.|..       ||:   :..||
  Fly   619 TLMAVTQLVIEGTQPHAPYNITGKATESSITLQWLPGYSGGSEYKQDYTIWFREAGVNDWQTISV 683

Mouse   533 -----PMAVIIGVAVGAGVAFLV---------LMATIV-------AFCCARSQRSTGGRPG---- 572
                 ....|.|:|.|....|.|         :|:.::       |....|:.::....|.
  Fly   684 TPSGSTQVTINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAAPRNVKAATQPPDSFFQ 748

Mouse   573 -----------------ISGRGT----EKKARLRLPRRANLKGVVSAKNDIRVEIVHKEPSSGRE 616
                             ...|||    ..|.|::.|:....:.|...:......|..:.|.....
  Fly   749 LMPDEADLLAYFDIYFHTDSRGTLVYSPPKLRVKGPKPGPPRNVSVTEVSNGFLITWQSPLERAH 813

Mouse   617 AEDHTTIKQLMMDRGEFQQDSVLKQLE--VLKEEEKEF--QNLKDPTNGYYSV--NTFKEHHSTP 675
            .....|||        ::.|:..|.|.  .::.||.::  :||......|:.|  |:.|.:.|:.
  Fly   814 IVKFYTIK--------YRTDAQWKTLNRGQIRPEETQYLVKNLVGGRTYYFRVLANSEKSYESSD 870

Mouse   676 TISLSSCQPDLRPTGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLG--MGSSSIELCEREFQR 738
            .:             |..||..:....|.:.:.| |.|:     |::.  :...::::|.:..:|
  Fly   871 EV-------------KFPVPARVKHKAITAGVVG-GILF-----FIVAIILSVCAVKICNKRKRR 916

Mouse   739 GSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSH-HSQSSSQNSDPSRPLQRRMQTH 802
               .....|....|              :...|...:|::.| |::|:...|....||::..||.
  Fly   917 ---KQEKEFNMVAC--------------RITDARNIAANNHHLHNRSTGSISSGQVPLKKYKQTR 964

Mouse   803 V 803
            :
  Fly   965 I 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653	28/130 (22%)
		Ig strand A'	56..60	CDD:409353	2/6 (33%)
		Ig strand B	64..71	CDD:409353	2/6 (33%)
		Ig strand C	78..82	CDD:409353	3/4 (75%)
		Ig strand C'	84..87	CDD:409353	0/2 (0%)
		Ig strand D	97..101	CDD:409353	1/3 (33%)
		Ig strand E	104..116	CDD:409353	3/16 (19%)
		Ig strand G	132..143	CDD:409353	3/27 (11%)
		IgI_2_KIRREL3-like	149..246	CDD:409416	25/103 (24%)
		Ig strand B	166..170	CDD:409416	1/3 (33%)
		Ig strand C	180..184	CDD:409416	1/3 (33%)
		Ig strand E	210..214	CDD:409416	2/3 (67%)
		Ig strand F	224..229	CDD:409416	1/4 (25%)
		Ig strand G	239..242	CDD:409416	0/2 (0%)
		Ig	<267..334	CDD:416386	23/77 (30%)
		Ig strand B	267..274	CDD:409353	3/6 (50%)
		Ig strand C	279..286	CDD:409353	2/6 (33%)
		Ig strand C'	288..291	CDD:409353	1/2 (50%)
		Ig strand D	298..302	CDD:409353	1/3 (33%)
		Ig strand E	304..310	CDD:409353	1/5 (20%)
		Ig strand G	321..334	CDD:409353	3/13 (23%)
		Ig	335..416	CDD:416386	18/90 (20%)
		Ig strand A'	343..347	CDD:409353	0/3 (0%)
		Ig strand B	350..360	CDD:409353	2/9 (22%)
		Ig strand C	365..371	CDD:409353	2/14 (14%)
		Ig strand E	381..387	CDD:409353	1/5 (20%)
		IgI_5_KIRREL3	418..515	CDD:409479	26/117 (22%)
		Ig strand B	436..440	CDD:409479	0/3 (0%)
		Ig strand C	450..454	CDD:409479	1/3 (33%)
		Ig strand E	481..485	CDD:409479	0/3 (0%)
		Ig strand F	496..501	CDD:409479	1/8 (13%)
		Ig strand G	509..512	CDD:409479	2/3 (67%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989	23/118 (19%)
		IG_like	137..229	CDD:214653	22/94 (23%)
		I-set	253..341	CDD:254352	24/101 (24%)
		IGc2	268..331	CDD:197706	18/67 (27%)
		I-set	346..437	CDD:254352	28/102 (27%)
		Ig	349..437	CDD:299845	28/99 (28%)
		Ig	459..530	CDD:299845	16/70 (23%)
		IG_like	549..628	CDD:214653	16/79 (20%)
		IGc2	551..617	CDD:197706	13/65 (20%)
		FN3	633..725	CDD:238020	21/91 (23%)
		FN3	786..874	CDD:238020	18/108 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900