DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel3 and klg

DIOPT Version :9

Sequence 1:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus
Sequence 2:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	578	Identity:	112/578 - (19%)
Similarity:	187/578 - (32%)	Gaps:	185/578 - (32%)

- Green bases have known domain annotations that are detailed below.

Mouse    40 RRMNEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFV-LWIKDGLALGVGRDLSSYPQYLVVG 103
            |.::.|..|.         .|.|..:.|.|.:.....|| ||.:       |.::.:....:|..
  Fly   102 RFLSRGHTYR---------AVVGDTLVLPCQVENLGNFVLLWRR-------GTNVLTASNIMVTR 150

Mouse   104 N---HLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPIILGGPVISLRAGDP 165
            :   .|...::|:|...|.||...|.||......|.:...:.:||||....|.....:..|.|.|
  Fly   151 DERVRLIDGYNLEISDLEPQDAGDYVCQISDKINRDQVHTVEILVPPSVRAIPTSGQLQARKGGP 215

Mouse   166 LNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIV--CR 228
            :.|.|.. :..|..||.|.:|    :||..|...:.||.    :.||    ..:|..|:.|  |.
  Fly   216 ITLECKG-SGNPVPSIYWTKK----SGANKSTARIGDGP----ILTL----EKLERQQAGVYQCT 267

Mouse   229 ATNKAIPGGKETSVTIDIQ----HPPLVNLSVEPQPVLEDNIVTFHCSAKANPAVTQYRWAKRGH 289
            |.|     |....||:|::    :||  ::.||..                        |..
  Fly   268 ADN-----GVGDPVTVDMRLDVLYPP--DIQVEKS------------------------WIH--- 298

Mouse   290 IIKEASGELYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQSLLVDLGSDAVF 354
                 |||.:...:....|::||:
  Fly   299 -----SGEGFEAKLVCIVFADPVA----------------------------------------- 317

Mouse   355 SCAWIGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRA------------VVPRVGA 407
            :.:|..| |..|....|......:|...||::.::|||.|.|.|.|            :..|.||
  Fly   318 TVSWYQN-SFPIQSTDRRIMATRANRHMLTIRHIQQEDFGNYSCVADNSLGRSRKYMELSGRPGA 381

Mouse   408 GE------------REVTLTVNGPPIISSTQ------TQHALHGEKGQIKCFIRSTPPPDRIAWS 454
            .|            ..:|..::..|.:...:      ..:..:.:.|:...||.:  |..|.|..
  Fly   382 AEFYSPKWGRSPDSYNLTWKIDSYPPLEEVRLLYRRVQMNETYQQPGRWHDFILT--PEHRPASE 444

Mouse   455 WKENVLESGTSGRYTVETVNT---EEGVISTLT------ISNIVRADFQTIYNCTAWNSFGSDTE 510
            ...:::.      ||::.::.   .|.::....      :|:|    ||.:....:.:....|.|
  Fly   445 PLTHIMS------YTIKNLHPGGYYEAIVQAKNRYGWNEVSDI----FQFVVATNSQDIGPEDAE 499

Mouse   511 IIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRSTG 568
            ::...:..|...|              ||...|:.|....|:..:....|...:|..|
  Fly   500 VVASSKSRSNSAS--------------IGSLPGSTVLHTALLLALALSNCQFDRRRLG 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653	20/92 (22%)
		Ig strand A'	56..60	CDD:409353	0/3 (0%)
		Ig strand B	64..71	CDD:409353	2/6 (33%)
		Ig strand C	78..82	CDD:409353	3/4 (75%)
		Ig strand C'	84..87	CDD:409353	0/2 (0%)
		Ig strand D	97..101	CDD:409353	0/3 (0%)
		Ig strand E	104..116	CDD:409353	3/14 (21%)
		Ig strand G	132..143	CDD:409353	1/10 (10%)
		IgI_2_KIRREL3-like	149..246	CDD:409416	27/98 (28%)
		Ig strand B	166..170	CDD:409416	1/3 (33%)
		Ig strand C	180..184	CDD:409416	2/3 (67%)
		Ig strand E	210..214	CDD:409416	2/3 (67%)
		Ig strand F	224..229	CDD:409416	2/6 (33%)
		Ig strand G	239..242	CDD:409416	0/2 (0%)
		Ig	<267..334	CDD:416386	7/66 (11%)
		Ig strand B	267..274	CDD:409353	0/6 (0%)
		Ig strand C	279..286	CDD:409353	1/6 (17%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	0/3 (0%)
		Ig strand E	304..310	CDD:409353	1/5 (20%)
		Ig strand G	321..334	CDD:409353	0/12 (0%)
		Ig	335..416	CDD:416386	20/104 (19%)
		Ig strand A'	343..347	CDD:409353	0/3 (0%)
		Ig strand B	350..360	CDD:409353	1/9 (11%)
		Ig strand C	365..371	CDD:409353	1/5 (20%)
		Ig strand E	381..387	CDD:409353	2/5 (40%)
		IgI_5_KIRREL3	418..515	CDD:409479	16/111 (14%)
		Ig strand B	436..440	CDD:409479	1/3 (33%)
		Ig strand C	450..454	CDD:409479	2/3 (67%)
		Ig strand E	481..485	CDD:409479	0/9 (0%)
		Ig strand F	496..501	CDD:409479	0/4 (0%)
		Ig strand G	509..512	CDD:409479	1/2 (50%)
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	7/30 (23%)
		IG_like	109..195	CDD:214653	21/101 (21%)
		Ig	118..191	CDD:143165	18/79 (23%)
		IG_like	205..274	CDD:214653	24/86 (28%)
		IGc2	213..273	CDD:197706	23/77 (30%)
		IGc2	301..367	CDD:197706	19/107 (18%)
		FN3	392..486	CDD:238020	15/105 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900