DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel3 and CG7166

DIOPT Version :9

Sequence 1:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus
Sequence 2:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	581	Identity:	113/581 - (19%)
Similarity:	196/581 - (33%)	Gaps:	167/581 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 LCFFLFSQELGLQKRGCCLVLGY----MAKDKFRRMNEGQVYSFSQQPQDQVVVSGQPVTLLCAI 71
            |..:|||..|.|  .|...:|..    ....||  ::.|.:|.         |:.|:.:.|.|.:
  Fly    11 LVLYLFSFSLSL--IGGSFILPENDPPTTAPKF--LSRGHLYK---------VIVGETIELPCKV 62

Mouse    72 PEYDGFV-LWIKDGLALGVGR-DLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAI 134
            .....|| ||.|....|..|. .::...::.:|     |:::|:|...:.||...|.||......
  Fly    63 QNLGSFVLLWRKGSSVLTAGHLKITRDQRFKIV-----GDYNLQINGVKTQDAGDYICQLGDQEN 122

Mouse   135 RSRPARLTVLVPPDDPIILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTL 199
            |.:...:.:||||....:.....::.|.|..:.|.|.| :..|..:|.|.:| :|.:|.|:
  Fly   123 RDQVHTVEILVPPTLRALPHNGQVTARKGSTVTLECKA-SGNPVPTIFWFKK-DVFSGPTH---- 181

Mouse   200 LRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLED 264
            |.|.      |||.:...|..:..:..|.|.|     |.:..|::|||
  Fly   182 LSDS------STLILENVDRHHAGTYQCSADN-----GVKDRVSMDIQ----------------- 218

Mouse   265 NIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVDYTYFSEPVSCEVTNALGSTNLSRTV 329
                                                                            :
  Fly   219 ----------------------------------------------------------------L 219

Mouse   330 DVYFGPRMTSEPQSLLVDLGSDAVFSCAWIGNPSLTIVWMK---------RGSGVVLSNEKTLTL 385
            .:...|.:|.|...:....|.|....|...|:.:..::|.:         |.|.....:..:|.:
  Fly   220 TILSPPEITVEKSWVHASEGYDVELVCIVHGDVNSEMLWYQNSFLLDATDRRSMYPRDDRYSLII 284

Mouse   386 KSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP----IISSTQTQHALHG--EKGQIKCFIRS 444
            ::.:..|.|.|.|   |.....|..:..:.|:|.|    .||.     ||.|  :...:...|.|
  Fly   285 RNFQPTDFGNYSC---VADNALGRTKKYIEVSGRPGPADFISP-----ALSGFLDHYNLTWTIES 341

Mouse   445 TPPPDRIAWSWK-----ENVLESGTSGRYTVE-TVNTEEGVISTLTISNIVR-ADFQTIY----- 497
            .||.|.|...::     |.....|....|.:: |....:|  |...:|.:|: .:...:|
  Fly   342 IPPLDEIKLLYRRLLMNETYQHPGKWHEYHIKPTPIRTDG--SHFLMSYLVKNLEHNAVYEAIVQ 404

Mouse   498 --NCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIV 556
              |...||..   ::|.:...:..::.....:|.:   |.:...:.:...|:.::|.|.|:
  Fly   405 AKNKYGWNEI---SDIHQFYTRNHDLLLDIDMEYK---MGISSNIRISPTVSGIILSAFIL 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653	21/90 (23%)
		Ig strand A'	56..60	CDD:409353	0/3 (0%)
		Ig strand B	64..71	CDD:409353	2/6 (33%)
		Ig strand C	78..82	CDD:409353	3/4 (75%)
		Ig strand C'	84..87	CDD:409353	0/2 (0%)
		Ig strand D	97..101	CDD:409353	0/3 (0%)
		Ig strand E	104..116	CDD:409353	3/11 (27%)
		Ig strand G	132..143	CDD:409353	1/10 (10%)
		IgI_2_KIRREL3-like	149..246	CDD:409416	23/96 (24%)
		Ig strand B	166..170	CDD:409416	1/3 (33%)
		Ig strand C	180..184	CDD:409416	1/3 (33%)
		Ig strand E	210..214	CDD:409416	3/3 (100%)
		Ig strand F	224..229	CDD:409416	1/4 (25%)
		Ig strand G	239..242	CDD:409416	0/2 (0%)
		Ig	<267..334	CDD:416386	0/66 (0%)
		Ig strand B	267..274	CDD:409353	0/6 (0%)
		Ig strand C	279..286	CDD:409353	0/6 (0%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	0/3 (0%)
		Ig strand E	304..310	CDD:409353	0/5 (0%)
		Ig strand G	321..334	CDD:409353	0/12 (0%)
		Ig	335..416	CDD:416386	17/89 (19%)
		Ig strand A'	343..347	CDD:409353	0/3 (0%)
		Ig strand B	350..360	CDD:409353	2/9 (22%)
		Ig strand C	365..371	CDD:409353	1/14 (7%)
		Ig strand E	381..387	CDD:409353	1/5 (20%)
		IgI_5_KIRREL3	418..515	CDD:409479	26/116 (22%)
		Ig strand B	436..440	CDD:409479	0/3 (0%)
		Ig strand C	450..454	CDD:409479	1/3 (33%)
		Ig strand E	481..485	CDD:409479	1/3 (33%)
		Ig strand F	496..501	CDD:409479	2/11 (18%)
		Ig strand G	509..512	CDD:409479	0/2 (0%)
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	21/87 (24%)
		Ig	56..116	CDD:143165	16/64 (25%)
		IG_like	144..221	CDD:214653	26/174 (15%)
		IGc2	151..209	CDD:197706	20/74 (27%)
		IG_like	232..313	CDD:214653	14/83 (17%)
		Ig	242..311	CDD:143165	12/71 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810