DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel3 and dpr10

DIOPT Version :9

Sequence 1:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus
Sequence 2:	NP_729591.1	Gene:	dpr10 / 39180	FlyBaseID:	FBgn0052057	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	399	Identity:	91/399 - (22%)
Similarity:	145/399 - (36%)	Gaps:	116/399 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse   251 LVNLSV--EPQPVLEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVDYTYFSEPVS 313
            |..|:|  :.|.|..:|    |.:|:|.|..........||...|            .||...:.
  Fly    12 LTGLAVCYQRQSVSNNN----HNNAEAKPTHAPPSHYPHGHKWNE------------PYFDLTMP 60

Mouse   314 CEVTNALGSTNLSRTVDVYFGPRMTSEPQSLLVDLGSDAVFSCAWIGNPSLTIVWMKRGSGVVLS 378
            ..:|:.:|.:       .|.|.|:.        .||:..|   |||.:..|.|:.:  |:....:
  Fly    61 RNITSLVGKS-------AYLGCRVK--------HLGNKTV---AWIRHRDLHILTV--GTYTYTT 105

Mouse   379 NEK------------TLTLKSVRQEDAGKYVCRA-------------VVPRVGA----------- 407
            :::            ||.:|..:|.|||.|.|:.             :|..:.|
  Fly   106 DQRFQTSYHRDIDEWTLQIKWAQQRDAGVYECQISTQPVRSYSVNLNIVDLIDAETSDIMQQYYN 170

Mouse   408 ------GEREVTLTVN-------GPPIISSTQTQHALHG-----EKG---QIKCFIRSTP-PPDR 450
                  .|..|..:.|       ||....:..|...|.|     :||   .:.|.|:.:| ||..
  Fly   171 DDAFYIAENRVYQSSNDEFAGMFGPIQTVAVPTATILGGPDLYVDKGSTINLTCIIKFSPEPPTH 235

Mouse   451 IAWSWKENVLESGTS-GRYTVETVNTEEGVISTLTISNIVRADF--QTIYNCTAWNSFGSDTEII 512
            |.|..::.||...|| ||...:|:.:||    |.:|..|..||.  ...|:|     :.|:|||.
  Fly   236 IFWYHQDKVLSEETSGGRLKFKTIKSEE----TKSILLIYDADLLHSGKYSC-----YPSNTEIA 291

Mouse   513 RLKEQGSEMKSGAGLEAESVPMAVII-------GVAVGAGVAFLVLMATIVAF-CCARSQRSTGG 569
            .::....:.:....::..:.|.||.:       |.|..|......::|.:|.. .|:.....:||
  Fly   292 SIRVHVLQGERPEAMQTNAAPAAVALACWSCHFGQATQAVRVISTMVAALVLLEACSSLLLQSGG 356

Mouse   570 RPGISGRGT 578
            ..|..|.|:
  Fly   357 GGGCPGGGS 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653
		Ig strand A'	56..60	CDD:409353
		Ig strand B	64..71	CDD:409353
		Ig strand C	78..82	CDD:409353
		Ig strand C'	84..87	CDD:409353
		Ig strand D	97..101	CDD:409353
		Ig strand E	104..116	CDD:409353
		Ig strand G	132..143	CDD:409353
		IgI_2_KIRREL3-like	149..246	CDD:409416
		Ig strand B	166..170	CDD:409416
		Ig strand C	180..184	CDD:409416
		Ig strand E	210..214	CDD:409416
		Ig strand F	224..229	CDD:409416
		Ig strand G	239..242	CDD:409416
		Ig	<267..334	CDD:416386	12/66 (18%)
		Ig strand B	267..274	CDD:409353	1/6 (17%)
		Ig strand C	279..286	CDD:409353	0/6 (0%)
		Ig strand C'	288..291	CDD:409353	2/2 (100%)
		Ig strand D	298..302	CDD:409353	0/3 (0%)
		Ig strand E	304..310	CDD:409353	2/5 (40%)
		Ig strand G	321..334	CDD:409353	2/12 (17%)
		Ig	335..416	CDD:416386	23/122 (19%)
		Ig strand A'	343..347	CDD:409353	0/3 (0%)
		Ig strand B	350..360	CDD:409353	3/9 (33%)
		Ig strand C	365..371	CDD:409353	1/5 (20%)
		Ig strand E	381..387	CDD:409353	2/17 (12%)
		IgI_5_KIRREL3	418..515	CDD:409479	34/108 (31%)
		Ig strand B	436..440	CDD:409479	1/6 (17%)
		Ig strand C	450..454	CDD:409479	1/3 (33%)
		Ig strand E	481..485	CDD:409479	1/3 (33%)
		Ig strand F	496..501	CDD:409479	2/4 (50%)
		Ig strand G	509..512	CDD:409479	2/2 (100%)
dpr10	NP_729591.1	Ig	63..143	CDD:299845	23/99 (23%)
		IG_like	210..297	CDD:214653	29/95 (31%)
		IGc2	217..287	CDD:197706	24/78 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810