DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel3 and dpr19

DIOPT Version :9

Sequence 1:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus
Sequence 2:	NP_001260336.1	Gene:	dpr19 / 34408	FlyBaseID:	FBgn0032233	Length:	385	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	99/493 - (20%)
Similarity:	154/493 - (31%)	Gaps:	165/493 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MRPFQLDLLFLCFFL-----FSQELG----LQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQD 56
            |.|.:..|...||.|     || ::|    .|..     .|...:.:|...|..:|
  Fly     1 MEPKRWHLHLSCFLLLLSSTFS-DVGKITSSQNH-----FGNTLQSQFNTKNNTRV--------- 50

Mouse    57 QVVVSGQPVTLLCAIP-EYDGFVLWI--KDGLALGVGRDL-SSYPQYLVVGNHLSGEHHLKILRA 117
             :...|....|.|.:. .....|.||  ||...|.||... ||..::||......|...|:|...
  Fly    51 -IAQKGGLAILPCVVKVNSPATVSWIRRKDFQLLTVGLSTHSSDKRFLVEHTRHMGHWSLRIKAV 114

Mouse   118 ELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPIILGGPVISLRAGDPLNLTCHADNA-KPAASI 181
            ..:|...||||......:|....|.::....:  |...|.:.:.....|.|.|....| :..|.:
  Fly   115 REEDRGFYECQLSIYPTQSIVIELKIVEAVAE--ISSAPELHIDETSTLRLECKLKRATENPAFV 177

Mouse   182 IWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDI 246
            .|....::||         .|.:...:|::  |...:.::||
  Fly   178 FWYHDSKMIN---------YDSQGGFVVTS--IGQSNPQSGQ----------------------- 208

Mouse   247 QHPPLVNLSVEPQPVLEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVDYTYFSEP 311
                                  |:.|:.||.:        |..:..|:|..:..:.:.   .|:.
  Fly   209 ----------------------FYRSSPANKS--------RATMPMESSNGVLNSLLG---SSDA 240

Mouse   312 VSCEVTNALGSTNLSRTVDVYFGPRMTSEPQSLLVDLGSDAVFSCAWIGNPSLTIVWMKRGSGVV 376
            :.....|...||           |.||.:.||             |::.|||:::
  Fly   241 IKAPAANVPSST-----------PYMTQQHQS-------------AYLLNPSVSV---------- 271

Mouse   377 LSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCF 441
                  ||:|.|....||.|.|      ..:..|..::||            |.|.|||
  Fly   272 ------LTVKQVNFRHAGNYTC------APSNARPASITV------------HVLRGEK------ 306

Mouse   442 IRSTPPPDRIAWSWKENVLESGTSGRYTVETVNTEEGV 479
            ..:....:|.....:.|  .:||.|..|:..:|...||
  Fly   307 TAAMQHANRSILDTETN--GNGTFGLITLGGLNGTSGV 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653	25/92 (27%)
		Ig strand A'	56..60	CDD:409353	0/3 (0%)
		Ig strand B	64..71	CDD:409353	2/6 (33%)
		Ig strand C	78..82	CDD:409353	3/5 (60%)
		Ig strand C'	84..87	CDD:409353	0/2 (0%)
		Ig strand D	97..101	CDD:409353	0/3 (0%)
		Ig strand E	104..116	CDD:409353	3/11 (27%)
		Ig strand G	132..143	CDD:409353	2/10 (20%)
		IgI_2_KIRREL3-like	149..246	CDD:409416	15/97 (15%)
		Ig strand B	166..170	CDD:409416	2/3 (67%)
		Ig strand C	180..184	CDD:409416	0/3 (0%)
		Ig strand E	210..214	CDD:409416	0/3 (0%)
		Ig strand F	224..229	CDD:409416	0/4 (0%)
		Ig strand G	239..242	CDD:409416	0/2 (0%)
		Ig	<267..334	CDD:416386	11/66 (17%)
		Ig strand B	267..274	CDD:409353	2/6 (33%)
		Ig strand C	279..286	CDD:409353	0/6 (0%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	0/3 (0%)
		Ig strand E	304..310	CDD:409353	0/5 (0%)
		Ig strand G	321..334	CDD:409353	2/12 (17%)
		Ig	335..416	CDD:416386	18/80 (23%)
		Ig strand A'	343..347	CDD:409353	1/3 (33%)
		Ig strand B	350..360	CDD:409353	1/9 (11%)
		Ig strand C	365..371	CDD:409353	0/5 (0%)
		Ig strand E	381..387	CDD:409353	2/5 (40%)
		IgI_5_KIRREL3	418..515	CDD:409479	14/62 (23%)
		Ig strand B	436..440	CDD:409479	0/3 (0%)
		Ig strand C	450..454	CDD:409479	1/3 (33%)
		Ig strand E	481..485	CDD:409479
		Ig strand F	496..501	CDD:409479
		Ig strand G	509..512	CDD:409479
dpr19	NP_001260336.1	IG_like	50..127	CDD:214653	24/86 (28%)
dpr19	NP_001260336.1	IGc2	55..125	CDD:197706	21/69 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810