DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel3 and DIP-zeta

DIOPT Version :9

Sequence 1:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus
Sequence 2:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	461	Identity:	94/461 - (20%)
Similarity:	152/461 - (32%)	Gaps:	153/461 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse    50 FSQQPQDQVVVSGQPVTLLCAIPEYDGF-VLWIKDGLALGVGRDLSSYPQ--YLVVGNH------ 105
            |::..::..|.:|:.|.|.|::.....: |.|:             .:.|  .|.|.||
  Fly   115 FTEYIENVTVPAGRNVKLGCSVKNLGSYKVAWM-------------HFEQSAILTVHNHVITRNP 166

Mouse   106 -LSGEH---------HLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPIILGGPVISL 160
             :|..|         :|.|.....:|...|.||......:::...|.|:|||:....|....:.:
  Fly   167 RISVTHDKHDRHRTWYLHINNVHEEDRGRYMCQINTVTAKTQFGYLNVVVPPNIDDSLSSSDVIV 231

Mouse   161 RAGDPLNLTCHADNAKPAASIIWLR---------KGEVIN---GATYSKTLLRDGKRESIVSTLF 213
            |.|..::|.|.| :..|...|.|.|         |..::|   |.|...|.         :|.|.
  Fly   232 REGANISLRCRA-SGSPRPIIKWKRDDNSRIAINKNHIVNEWEGDTLEITR---------ISRLD 286

Mouse   214 ISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNIVTFHCSAKANPA 278
            :.        :.:|.|:| .:|......:.:.:..||::.:..:.....|...||..|..:|:|.
  Fly   287 MG--------AYLCIASN-GVPPTVSKRIKVSVDFPPMLLIPHQLVGAPEGFNVTIECFTEAHPT 342

Mouse   279 VTQYRWAK-RGHIIKEASGELYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQ 342
            ...| |.: .|.||.::          :.|..|
  Fly   343 SLNY-WTRGEGPIIHDS----------HKYKVE-------------------------------- 364

Mouse   343 SLLVDLGSDAVFSCAWIGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGA 407
                          |.:|.|:             ......||:.:|...|.|.|.|.|..||
  Fly   365 --------------ATVGLPA-------------YKTHMKLTIINVSSGDDGIYKCVAKNPR--- 399

Mouse   408 GERE--VTLTVNGPPI-----ISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWS------WKENV 459
            ||.:  :.|.|:.||.     |.||.|.   .||.|....:....|...|..::      ::.|:
  Fly   400 GETDGIIRLYVSYPPTTASSGIYSTDTH---WGENGINNNYAYGGPDSTRSIYAQDKNTRYQSNL 461

Mouse   460 LESGTS 465
            .|.|.|
  Fly   462 NEIGLS 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653	21/107 (20%)
		Ig strand A'	56..60	CDD:409353	0/3 (0%)
		Ig strand B	64..71	CDD:409353	3/6 (50%)
		Ig strand C	78..82	CDD:409353	2/3 (67%)
		Ig strand C'	84..87	CDD:409353	0/2 (0%)
		Ig strand D	97..101	CDD:409353	1/5 (20%)
		Ig strand E	104..116	CDD:409353	6/27 (22%)
		Ig strand G	132..143	CDD:409353	1/10 (10%)
		IgI_2_KIRREL3-like	149..246	CDD:409416	21/108 (19%)
		Ig strand B	166..170	CDD:409416	1/3 (33%)
		Ig strand C	180..184	CDD:409416	1/3 (33%)
		Ig strand E	210..214	CDD:409416	2/3 (67%)
		Ig strand F	224..229	CDD:409416	1/4 (25%)
		Ig strand G	239..242	CDD:409416	0/2 (0%)
		Ig	<267..334	CDD:416386	12/67 (18%)
		Ig strand B	267..274	CDD:409353	3/6 (50%)
		Ig strand C	279..286	CDD:409353	2/6 (33%)
		Ig strand C'	288..291	CDD:409353	1/2 (50%)
		Ig strand D	298..302	CDD:409353	0/3 (0%)
		Ig strand E	304..310	CDD:409353	1/5 (20%)
		Ig strand G	321..334	CDD:409353	0/12 (0%)
		Ig	335..416	CDD:416386	16/82 (20%)
		Ig strand A'	343..347	CDD:409353	0/3 (0%)
		Ig strand B	350..360	CDD:409353	1/9 (11%)
		Ig strand C	365..371	CDD:409353	0/5 (0%)
		Ig strand E	381..387	CDD:409353	2/5 (40%)
		IgI_5_KIRREL3	418..515	CDD:409479	15/59 (25%)
		Ig strand B	436..440	CDD:409479	1/3 (33%)
		Ig strand C	450..454	CDD:409479	1/3 (33%)
		Ig strand E	481..485	CDD:409479
		Ig strand F	496..501	CDD:409479
		Ig strand G	509..512	CDD:409479
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	22/108 (20%)
		Ig	130..200	CDD:143165	17/82 (21%)
		I-set	226..310	CDD:254352	20/102 (20%)
		IGc2	233..298	CDD:197706	18/83 (22%)
		Ig	313..410	CDD:299845	31/169 (18%)
		IG_like	325..410	CDD:214653	29/157 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810