DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel3 and dpr18

DIOPT Version :9

Sequence 1:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus
Sequence 2:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	106/547 - (19%)
Similarity:	174/547 - (31%)	Gaps:	209/547 - (38%)

- Green bases have known domain annotations that are detailed below.

Mouse   158 ISLRAGDPLNL--TCHADNAKPAASIIWLRKGEVINGATYSKTLLRD--GKRESIVST------- 211
            |:|..|..:.:  |...:...|:|| ...|.||       :::||.|  .|.:|.:||
  Fly    38 IALVIGSQVQVLYTTSVETKSPSAS-EQSRNGE-------NRSLLFDDYNKTKSTLSTADYLSAT 94

Mouse   212 -----LFISPGDVENGQSIVCRATN----------------KAIPGGKETS-------------- 241
                 .|.|....|:...:...|:|                ...||..|.|
  Fly    95 RATLYAFSSQDQDEDHSQMPIEASNAPHSPIPTKMSRGKIPMETPGSMEFSSNSLPIKNVGTTDQ 159

Mouse   242 -VTIDIQHPPLVNLSVE----PQPVLEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRT 301
             .|:.:......:|.|:    .||: :......|.:|.....||:...:|..|  :...|
  Fly   160 LTTVTMPTTAFASLKVDRSTMKQPI-DSTRTRNHWTASGFARVTERPRSKHHH--EHHWG----- 216

Mouse   302 TVDYTYFSEPVSCEVTNALGSTNLSRTVDVY-----------------FGPRMTSEPQSLLVDLG 349
                .:|.||::    :|....||...|.::                 ...|.|:|..|||
  Fly   217 ----PFFEEPIN----SATSGDNLVSAVHLFTEAVLNCRVGMLKDKTVMWVRRTAEKVSLL---- 269

Mouse   350 SDAVFSCAWIGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVV--PRVGAGEREV 412
              .|.:..:.|:|.:.:.:.       ..|...|.:...:.||||.|:|:...  |||..    .
  Fly   270 --TVGNVTYSGDPRIRVKFQ-------YPNNWRLLINPTQTEDAGVYMCQVSTHPPRVFT----T 321

Mouse   413 TLTVNGPP---------------------------------------IISST------------- 425
            .|||..||                                       |:.||
  Fly   322 NLTVLEPPLRIIDEHERDVGDRYYKSGSTVDLQCQISRSFFQKERQTILKSTDSANDAVQKLINE 386

Mouse   426 ------------QTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETVNTEEG 478
                        ||||...|:..: |.|.:.      |.|:..|..|:..|:.|.:|..|    .
  Fly   387 TTSELNLIGNVNQTQHKFSGQDLE-KYFTKF------ITWAKDEEPLQGMTNRRLSVSDV----W 440

Mouse   479 VISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKS------GAGLEAESVPMAVI 537
            :.|.::|.:...:|... |:|:....|   |.|::::....|:.:      |:..|..|:.|
  Fly   441 LTSRISIGDAKLSDSGN-YSCSLGRLF---TVIVQVQVLTGELPAAVQHNIGSRTEIYSLAM--- 498

Mouse   538 IGVAVGAGVAFLVLMATIVAFCCARSQ 564
            :|          .|:..|..|.|.:::
  Fly   499 LG----------HLLVLIFLFTCLKTE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653
		Ig strand A'	56..60	CDD:409353
		Ig strand B	64..71	CDD:409353
		Ig strand C	78..82	CDD:409353
		Ig strand C'	84..87	CDD:409353
		Ig strand D	97..101	CDD:409353
		Ig strand E	104..116	CDD:409353
		Ig strand G	132..143	CDD:409353
		IgI_2_KIRREL3-like	149..246	CDD:409416	27/134 (20%)
		Ig strand B	166..170	CDD:409416	0/5 (0%)
		Ig strand C	180..184	CDD:409416	1/3 (33%)
		Ig strand E	210..214	CDD:409416	2/15 (13%)
		Ig strand F	224..229	CDD:409416	0/4 (0%)
		Ig strand G	239..242	CDD:409416	2/17 (12%)
		Ig	<267..334	CDD:416386	14/83 (17%)
		Ig strand B	267..274	CDD:409353	1/6 (17%)
		Ig strand C	279..286	CDD:409353	2/6 (33%)
		Ig strand C'	288..291	CDD:409353	1/2 (50%)
		Ig strand D	298..302	CDD:409353	0/3 (0%)
		Ig strand E	304..310	CDD:409353	1/5 (20%)
		Ig strand G	321..334	CDD:409353	3/29 (10%)
		Ig	335..416	CDD:416386	21/82 (26%)
		Ig strand A'	343..347	CDD:409353	3/3 (100%)
		Ig strand B	350..360	CDD:409353	1/9 (11%)
		Ig strand C	365..371	CDD:409353	0/5 (0%)
		Ig strand E	381..387	CDD:409353	1/5 (20%)
		IgI_5_KIRREL3	418..515	CDD:409479	28/160 (18%)
		Ig strand B	436..440	CDD:409479	0/3 (0%)
		Ig strand C	450..454	CDD:409479	1/3 (33%)
		Ig strand E	481..485	CDD:409479	1/3 (33%)
		Ig strand F	496..501	CDD:409479	2/4 (50%)
		Ig strand G	509..512	CDD:409479	1/2 (50%)
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	21/99 (21%)
		Ig	<258..326	CDD:299845	22/84 (26%)
		IGc2	<417..461	CDD:197706	12/48 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810