DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel3 and DIP-alpha

DIOPT Version :9

Sequence 1:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus
Sequence 2:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	92/403 - (22%)
Similarity:	155/403 - (38%)	Gaps:	107/403 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse   196 SKTLLR-------DGKRESIVSTLFI----------SPGDVENGQSIVCRATNKAIPGGKETSVT 243
            :|.|||       |...:.::..|.|          .|..||:       .:|.::..|::.:.|
  Fly     5 AKRLLRNFQFTSCDRNGKMLIHLLLIVSLLEAIGAFQPEFVES-------ISNVSVAVGRDATFT 62

Mouse   244 IDIQH-----PPLVNLSVEPQPVLEDNIVTFHCSAKANPAVT-----QYRWAKRGHIIKEASGEL 298
            ..::|     ...:....:....:.:|::|.      ||.||     |..|......:.|.....
  Fly    63 CHVRHLGGYRVGWLKADTKAIQAIHENVITH------NPRVTVSHLDQNTWNLHIKAVSEEDRGG 121

Mouse   299 YRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQS--LLVDLGSDAVFSCAWIGN 361
            |...::    ::|:..::          ..:||...|...||..|  ::|..||....:|...|.
  Fly   122 YMCQLN----TDPMKSQI----------GFLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRARGY 172

Mouse   362 PSLTIVWMKR-GSGVVLSNE---KTLT---------LKSVRQEDAGKYVCRA---VVPRVGAGER 410
            |...:.|.:. |:.:||.:.   |||.         |..:.:.:.|.|:|.|   |.|.|   .:
  Fly   173 PEPIVTWRREDGNEIVLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIASNGVPPSV---SK 234

Mouse   411 EVTLTVNGPPIIS-STQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESG----TSGRYTV 470
            .::|:::..|:|. ..|...|..|...||:|.:.::|.....   |   :.::|    |||:|.|
  Fly   235 RISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPKSINY---W---IKDTGEMIVTSGKYHV 293

Mouse   471 ETVNTEEGVISTLTISNIVRADFQT----IYNCTAWNSFGSDTEIIRLKE-----------QGSE 520
            :  .:.:.:..| .:|.||| .||.    .|.|.|.||.|.....|||.|           .|..
  Fly   294 Q--ESSQSMYET-KMSMIVR-KFQKDDVGSYRCIAKNSLGEVDSSIRLYEIPGPNRNKNPLNGGG 354

Mouse   521 MKSGAG--LEAES 531
            ...|||  |:|::
  Fly   355 KGGGAGGSLDADA 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653
		Ig strand A'	56..60	CDD:409353
		Ig strand B	64..71	CDD:409353
		Ig strand C	78..82	CDD:409353
		Ig strand C'	84..87	CDD:409353
		Ig strand D	97..101	CDD:409353
		Ig strand E	104..116	CDD:409353
		Ig strand G	132..143	CDD:409353
		IgI_2_KIRREL3-like	149..246	CDD:409416	13/66 (20%)
		Ig strand B	166..170	CDD:409416
		Ig strand C	180..184	CDD:409416
		Ig strand E	210..214	CDD:409416	1/3 (33%)
		Ig strand F	224..229	CDD:409416	0/4 (0%)
		Ig strand G	239..242	CDD:409416	0/2 (0%)
		Ig	<267..334	CDD:416386	12/71 (17%)
		Ig strand B	267..274	CDD:409353	1/6 (17%)
		Ig strand C	279..286	CDD:409353	4/11 (36%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	1/3 (33%)
		Ig strand E	304..310	CDD:409353	0/5 (0%)
		Ig strand G	321..334	CDD:409353	2/12 (17%)
		Ig	335..416	CDD:416386	26/98 (27%)
		Ig strand A'	343..347	CDD:409353	1/5 (20%)
		Ig strand B	350..360	CDD:409353	2/9 (22%)
		Ig strand C	365..371	CDD:409353	1/5 (20%)
		Ig strand E	381..387	CDD:409353	4/14 (29%)
		IgI_5_KIRREL3	418..515	CDD:409479	31/105 (30%)
		Ig strand B	436..440	CDD:409479	2/3 (67%)
		Ig strand C	450..454	CDD:409479	0/3 (0%)
		Ig strand E	481..485	CDD:409479	1/3 (33%)
		Ig strand F	496..501	CDD:409479	2/4 (50%)
		Ig strand G	509..512	CDD:409479	0/2 (0%)
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	14/89 (16%)
		Ig	51..131	CDD:299845	13/89 (15%)
		I-set	144..240	CDD:254352	26/98 (27%)
		IGc2	159..228	CDD:197706	17/68 (25%)
		Ig	244..337	CDD:299845	30/102 (29%)
		I-set	244..337	CDD:254352	30/102 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810