DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf149 and rnf149

DIOPT Version :9

Sequence 1:	NP_001028307.2	Gene:	Rnf149 / 67702	MGIID:	2677438	Length:	394	Species:	Mus musculus
Sequence 2:	XP_012812754.1	Gene:	rnf149 / 780151	XenbaseID:	XB-GENE-972101	Length:	398	Species:	Xenopus tropicalis

Alignment Length:	376	Identity:	237/376 - (63%)
Similarity:	289/376 - (76%)	Gaps:	16/376 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse    20 LALALC--TPGVGGGALEWYSAMVSIEYVDPQSNLTVWSVSESGRFGESSLREERQGLVGVPRAP 82
            |..|||  |.|....:|||::|:|..||.:|.:|.||...:||||:|:||.::..|||||.||.|
Frog     7 LCSALCALTHGSSARSLEWFTALVRTEYTEPLTNSTVTGSTESGRYGDSSPKDTVQGLVGYPRDP 71

Mouse    83 APAEGCAPDTRFVAPGALGN-AP---WVALVARGGCTFKDKVLAAARRNASAVVVYNLESNGNAT 143
            ...|||.|||:::.||...: ||   |:||:||||||||:||..||.|.|||||:||...:||||
Frog    72 WQLEGCHPDTQYIVPGMPASPAPDSDWIALIARGGCTFKEKVFNAANRGASAVVIYNEAKSGNAT 136

Mouse   144 EPMSH-------AGTGNIVVIMISYPKGREIFDLVQKGIPVKMRIEIGTRHMQEFISGQSVVFVA 201
            ..|||       .||||.||||:|||||.||.:.:::.|||||.|.:||||:|||||||||||||
Frog   137 VSMSHLESMDTSEGTGNTVVIMVSYPKGMEILEPMRRDIPVKMVITMGTRHVQEFISGQSVVFVA 201

Mouse   202 IAFITMMIISLAWLIFYYIQRFLYTGSQFGSQNHRKETKKVIGQLPLHTVKHGEKGIDVDAENCA 266
            ||||||||||||||||||||||||||:|.|:|::||||||.|.||.||.||.||||||:||||||
Frog   202 IAFITMMIISLAWLIFYYIQRFLYTGAQCGNQSNRKETKKAISQLQLHRVKKGEKGIDIDAENCA 266

Mouse   267 VCIENFKVKDVIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALGYWGDPEDTQELPTPEAA 331
            |||||:|.||::|||||||||||:||||||::||||||||||||||||:|.:||:|.::..|.:.
Frog   267 VCIENYKTKDLVRILPCKHIFHRLCIDPWLIEHRTCPMCKLDVIKALGFWVEPEETVDIHVPVSI 331

Mouse   332 PG-RVSVGNLSVTSQDEERSE-SNLPSSSSSESGPHRPCLKEDAGEDTALL 380
            .| .:|:|.:|:| |:|.||| :||||||:..|......:||||||.||||
Frog   332 AGSSLSIGTVSIT-QEESRSEGNNLPSSSTGSSLQQSNSVKEDAGETTALL 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf149	NP_001028307.2	PA_GRAIL_like	45..181	CDD:239037	80/146 (55%)
		UPF0233	<193..>220	CDD:299753	26/26 (100%)
		zf-RING_2	263..306	CDD:290367	35/42 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..394		29/62 (47%)
rnf149	XP_012812754.1	PA_GRAIL_like	34..181	CDD:239037	80/146 (55%)
		UPF0233	<200..>220	CDD:299753	19/19 (100%)
		zf-RING_2	263..306	CDD:290367	35/42 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I20652
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H18337
Inparanoid	1	1.050	462	1.000	Inparanoid score	I8060
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		oto190950
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11983
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.080