DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf149 and rnf130

DIOPT Version :9

Sequence 1:	NP_001028307.2	Gene:	Rnf149 / 67702	MGIID:	2677438	Length:	394	Species:	Mus musculus
Sequence 2:	XP_009289393.1	Gene:	rnf130 / 553950	ZFINID:	ZDB-GENE-050522-525	Length:	428	Species:	Danio rerio

Alignment Length:	407	Identity:	151/407 - (37%)
Similarity:	221/407 - (54%)	Gaps:	45/407 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 RRPAAGVGARDALAVLALAL----CTPGVGGGAL-----EWYSAMVSIEYVDPQSNLTVWSVSES 60
            :|.||.......|..|.||.    |:..:|....     ::|||:|:...:|.:.|.........
Zfish     3 KRLAAPASCSSCLLALLLAFVSPRCSLSIGADKTMVNKEDYYSAIVNATVLDHKGNPQQMVTKND 67

Mouse    61 GRFGESSLREERQGLVGVPRAPAPA---EGCAPDTRFVAPGALGNAPWVALVARGGCTFKDKVLA 122
            ||:|::|.:.|.:|:|..|.|...|   :||.|.|||:.|..  ...|||::.||.||||:|:|.
Zfish    68 GRYGQNSPKTEAKGIVVAPAAVNGAVDLQGCCPHTRFIVPPK--TTHWVAIMQRGKCTFKEKILK 130

Mouse   123 AARRNASAVVVYNLESNGNATEPMSHAGTGNIVVIMISYPKGREIFDLVQKGIPVKMRIEIGTRH 187
            ||..|||||::|| .:....|..|:|.|||:||.:||:...|:||...::|...|.:.:.:|:|.
Zfish   131 AAAFNASAVIIYN-NNTKEDTVTMAHEGTGDIVAVMITESFGKEILGFLEKNQTVLVSVIVGSRG 194

Mouse   188 MQEFISGQSVVFVAIAFITMMIISLAWLIFYYIQRFLYTGSQFGSQNHRKE-TKKVIGQLPLHTV 251
            |.:.|:..|:|||:|:||.:||||.||||||:||:...|.::..||....: .||.|.:|...||
Zfish   195 MPKNINRGSLVFVSISFIVLMIISSAWLIFYFIQKIRDTSARDRSQRRLGDAAKKAISKLTTRTV 259

Mouse   252 KHGEKGIDVDAENCAVCIENFKVKDVIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALGYW 316
            |.|:|..:.|..:||||||.:::.||:|||||||:||::|:||||.:|.|||||||:::||||
Zfish   260 KRGDKETEPDFNHCAVCIEGYQLNDVVRILPCKHVFHKMCVDPWLNEHCTCPMCKLNILKALG-- 322

Mouse   317 GDPEDTQELPTPEAAPGRVSVGNLSVTSQDEERSES--------NLPSSSSSESGPHRPCLKEDA 373
                         ..|....|.|::.......||::        :|.|.:|....|.|.......
Zfish   323 -------------VMPNLPCVDNMAFDMDRMSRSQTSSQRTALVDLSSETSISLEPLRHSSSSQL 374

Mouse   374 GEDTALLGAGRSEPQHG 390
            ..|..|:      |:.|
Zfish   375 PSDEELI------PRSG 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf149	NP_001028307.2	PA_GRAIL_like	45..181	CDD:239037	54/138 (39%)
		UPF0233	<193..>220	CDD:299753	17/26 (65%)
		zf-RING_2	263..306	CDD:290367	27/42 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..394		14/78 (18%)
rnf130	XP_009289393.1	PA_GRAIL_like	49..188	CDD:239037	54/141 (38%)
rnf130	XP_009289393.1	zf-RING_2	271..314	CDD:290367	27/42 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010