DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf149 and SPAC57A7.09

DIOPT Version :9

Sequence 1:	NP_001028307.2	Gene:	Rnf149 / 67702	MGIID:	2677438	Length:	394	Species:	Mus musculus
Sequence 2:	NP_593372.1	Gene:	SPAC57A7.09 / 2542187	PomBaseID:	SPAC57A7.09	Length:	372	Species:	Schizosaccharomyces pombe

Alignment Length:	402	Identity:	85/402 - (21%)
Similarity:	129/402 - (32%)	Gaps:	164/402 - (40%)

- Green bases have known domain annotations that are detailed below.

Mouse    17 LAVLALALCTPGVGGGALE------WYSAMVSIEYVDPQSNLTVWSVSESGRFGE---------- 65
            |.|:||.|       |.|:      .::|...:....|..|:|:|  |....||:
pombe    20 LEVIALDL-------GVLDNIFIPKRFAASTDVAIQLPDRNVTLW--SRQAVFGKHFTNASATTV 75

Mouse    66 ------SSLREERQGLVGVPRAPAPAEGCAP----------DTRFVAPGALGNAPWV-------- 106
                  |:.:|:..|      .|...:..|.          |..::...:..:.|..
pombe    76 INLYLPSNFQEDMSG------CPNRNDTDASYFYENDIIDYDIEYIEQKSYSSKPSARVQKDDGG 134

Mouse   107 ----------ALVARGGCTFKDKVLAAARRNASAVVVYNLESNGNATEPMSHAGTGNIVVIMISY 161
                      .||.||.||:.||.|.|.|.....|:|      |:...|.|
pombe   135 ESKDEAILDFLLVQRGKCTYFDKALEAQRLGFKGVIV------GDNRSPSS-------------- 179

Mouse   162 PKGREIFDLVQKGIPVKMRIEIGTRHMQEFISGQSVVFVAIAFITMMIISLAW--LIFYYIQRF- 223
                  |.|.....|.|:              .:|.|.:...|::....:|.|  |:..|.|..
pombe   180 ------FRLHYMVAPDKV--------------DESKVHIPSLFVSTSSYNLLWSDLLHSYRQPLK 224

Mouse   224 LYT-----GSQF--------------------------GSQNHRKETKKVIGQLPLHTV-KHG-- 254
            ||.     |..|                          .:...:.:|::.|..||..|: :.|
pombe   225 LYAKPEELGDMFWPFLLCFSPSIIMLITVQALAIRKFIRTYRTKSKTRRFIEDLPSRTISREGFY 289

Mouse   255 --EKGIDVDAEN-------------------CAVCIENFKVKDVIRILPCKHIFHRICIDPWLLD 298
              |:.|:...:|                   |.:|:|:|...|.:..|||||.|||.||..|::|
pombe   290 SEEEEIENSTQNGELVPLMDESTRRATFGVECVICLESFTKGDKVVALPCKHEFHRPCIAKWIVD 354

Mouse   299 HR-TCPMCKLDV 309
            :| .||.|..:|
pombe   355 YRHACPTCNTEV 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf149	NP_001028307.2	PA_GRAIL_like	45..181	CDD:239037	34/179 (19%)
		UPF0233	<193..>220	CDD:299753	6/28 (21%)
		zf-RING_2	263..306	CDD:290367	21/62 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..394
SPAC57A7.09	NP_593372.1	COG5540	1..369	CDD:227827	85/402 (21%)
		Peptidases_S8_S53	<144..211	CDD:299169	23/106 (22%)
		zf-RING_2	320..362	CDD:290367	20/41 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810