Protein Alignment ST14 and flz

DIOPT Version :10

• Sequence 1: NP_068813.1
• Gene: ST14 / 6768
• HGNCID: 11344
• Length: 855
• Species: Homo sapiens
• Sequence 2: NP_001137622.1
• Gene: flz / 35902
• FlyBaseID: FBgn0286782
• Length: 1693
• Species: Drosophila melanogaster
• Alignment Length: 773
• Identity: 175/773 - (22%)
• Similarity: 276/773 - (35%)
• Gaps: 215/773 - (27%)

Human   199 FPTDSKT---VQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPAHARCQWALRGDADSVLSLTF 260
            |..|.|.   :|.|.:|...             :|||....|..|.|           |..:...
  Fly  1019 FMADDKLDAFIQSTAENIVG-------------STPGNYQPPLVATA-----------STPAYAH 1059

Human   261 RSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPSYNLTFHSS----QNVLLITLITNTE 321
            |.....|...:....|.:..|..|..|..|:.   ..|.:.||..:||    .|.|..:..:...
  Fly  1060 RPTSSGSYGHKKPGFVQINGTPKPPRPTVLIT---PKPTAINLVTYSSLSDDSNKLASSTSSYVT 1121

Human   322 RRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWN-----IEVPNNQHVKVR 381
            .| ||.:..                :...|..|.|.|..|.::..|.:     ..||::.  |..
  Fly  1122 GR-PGVQGV----------------SSNDFKDPGYFGSSPVHVAFTQSTTEAVYAVPSDD--KPA 1167

Human   382 FKFFYLLEPGVPAGTCPKDYV--EINGEKYCGERSQFV-----------VTSNSNKITVRFHSDQ 433
            |..::...|..||.:.|.:.|  .:..|.|... :.||           :::.|:.:|    ||.
  Fly  1168 FPGYFGPTPSYPAFSVPGEKVGQNVMEETYTSP-NDFVNFPPVRNPNLNMSAASSAVT----SDL 1227

Human   434 SYTDTGFLAEYLSYDSSD--------PCPGQFTCRTGRCIRKELRCDGWADCTDH--SDELNCSC 488
            ..:...|:.:.:..|...        ...|.|              :..||..:.  |::...:.
  Fly  1228 DLSTPAFVEDVVLKDKMHTLVHKLVASLQGNF--------------EALADMIEEPGSNKTVATY 1278

Human   489 DAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK-------SQQCNG 546
            .||...|     .||:..|....              |.:|...:..|..:|       ::..|.
  Fly  1279 QAGAGGT-----AKPVRVVTTRK--------------PVRTATTTRPKVTTKKPVTRVTTKAPNK 1324

Human   547 KDDCGDGSDEASCPKVNVVTC--------------TKHTYRCLNGLCLSKGNPECDGKEDCSDGS 597
            |......:......:...|..              |:.....:....:|...|..|   :..|..
  Fly  1325 KTSAVSTTTRKPATRRTTVAAKVTTTTRRPATKKPTRRVSSTVKTTTVSSARPADD---EIVDEE 1386

Human   598 DEKD---------------------------------------------CDCGLRSFTRQARVVG 617
            ||:|                                             .:||:|...:..|:||
  Fly  1387 DEEDVNPNPSDNEIDQGATLSSYGGANGRKIHSTSRTLPTPNLAFHSPSTECGVRPHVKSGRIVG 1451

Human   618 GTDADEGEWPWQVSLH-----ALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLG 677
            |..:..|.:||||.:.     .|...:.||..||:..::::||||   ..||..|    ..|.:|
  Fly  1452 GKGSTFGAYPWQVLVRESTWLGLFTKNKCGGVLITSRYVITAAHC---QPGFLAS----LVAVMG 1509

Human   678 LHD-----QSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASH 737
            ..|     :|:||.    .:.:||:|.|..::..||:.|:|||||:.|.::.:.:.|||:|:...
  Fly  1510 EFDISGDLESKRSV----TKNVKRVIVHRQYDPATFENDLALLELDSPVQFDTHIVPICMPNDVA 1570

Human   738 VFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL-----PQQITPRMMCVGFLSGG 797
            .| .|:...|||||..:|||....:||:.::.:|..:.|:.:.     .::|....:|.|:.:|.
  Fly  1571 DF-TGRMATVTGWGRLKYGGGVPSVLQEVQVPIIENSVCQEMFHTAGHNKKILTSFLCAGYANGQ 1634

Human   798 VDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV 855
            .|||:|||||||.....|||...||.||.|..||....||||.|...::.|::..|||
  Fly  1635 KDSCEGDSGGPLVLQRPDGRYELAGTVSHGIKCAAPYLPGVYMRTTFYKPWLRSITGV 1692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ST14	NP_068813.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		SEA	88..>162	CDD:460188
		CUB	227..332	CDD:238001	24/108 (22%)
		CUB	340..444	CDD:238001	24/121 (20%)
		LDLa	454..486	CDD:238060	5/33 (15%)
		LDLa	488..523	CDD:238060	6/34 (18%)
		LDLa	525..559	CDD:238060	6/40 (15%)
		LDLa	567..602	CDD:238060	8/93 (9%)
		Tryp_SPc	615..852	CDD:238113	87/251 (35%)
flz	NP_001137622.1	PRK11633	<365..>439	CDD:236940
		PRK10263	<547..>1005	CDD:236669
		PHA03247	<792..1096	CDD:223021	21/103 (20%)
		Tryp_SPc	1449..1689	CDD:238113	87/251 (35%)