Protein Alignment ST14 and Corin

DIOPT Version :10

• Sequence 1: NP_068813.1
• Gene: ST14 / 6768
• HGNCID: 11344
• Length: 855
• Species: Homo sapiens
• Sequence 2: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Alignment Length: 744
• Identity: 191/744 - (25%)
• Similarity: 269/744 - (36%)
• Gaps: 235/744 - (31%)

Human   198 AFPT---DSKTVQRT--QDNSCSFGLH-ARGVEL---MRFTTPGFPDSPY-----PAHAR--CQW 246
            |:||   .:||:..|  .:::.|||.: |.|..|   :||...  |..||     |.:..  .|.
  Fly   747 AYPTIKFVNKTIINTIHVEDTTSFGKNPAPGTCLPIIVRFCQG--PQIPYNYTVFPNYIGHFGQL 809

Human   247 ALRGDADSVLSLTFRSFDLASCDERGSDLVTVY-NTLSPMEPHALVQLCG----TYPPSYNLTFH 306
            ..:.|.||..:|.         |.|..:||::: .||       .|..||    |.||..
  Fly   810 ETQTDLDSYEALV---------DVRCYELVSLFLCTL-------FVPKCGQSGATVPPCK----- 853

Human   307 SSQNVLLITLITNTERRHPGFEATF-FQLPRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNI 370
                    ||.|.|.||...|...| ..||...:|  :|.|            .:|.:.||....
  Fly   854 --------TLCTETMRRCGFFFDVFGLSLPEYLNC--KLFK------------DFPSSEDCVGLD 896

Human   371 EVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSY 435
            ||                ...:.|.|.||
  Fly   897 EV----------------REVMRAATHPK------------------------------------ 909

Human   436 TDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKF 500
                             |.| |.|...||:.:|..|||..||.|.:||..|......:..|.:..
  Fly   910 -----------------CDG-FQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQ 956

Human   501 CKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDG------------ 553
            |.....:||.:.||....||:              .||..|:: ||  |.|.|
  Fly   957 CIGTKHICDGIIDCPYGQDER--------------NCLRLSER-NG--DVGTGVLEVYRIGQRQW 1004

Human   554 ------------SDEASC-----PKVNVVT-CTKHTYRCL----------------NGLCLSKGN 584
                        |..|.|     ..||..: .|:.|:|.|                ....|.:..
  Fly  1005 MPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEF 1069

Human   585 PECDGKED-------CSDGSDEKDCDCGLRSFTR---QARVVGGTDADEGEWPWQVSLHALG--- 636
            ..|...||       ||      :.:||.....|   ..|::|||.|..|.||:..::  ||
  Fly  1070 ANCKKTEDYPMADLTCS------NYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAI--LGGPE 1126

Human   637 QGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHP 701
            :...|...|||..|:::|:||.   ..:...|...||..||:..::..:..| |:.::|.:|.||
  Fly  1127 KIFYCAGVLISDQWVLTASHCV---GNYSVIDLEDWTIQLGVTRRNSFTYSG-QKVKVKAVIPHP 1187

Human   702 FFN-DFTFDYDIALLELEKPAEYSSMVRPICLPDAS--HVFPAGKAIWVTGWGHTQ---YGGTGA 760
            .:| ....|.||||.:|.....:...:.|:|||..|  ::.| |....|.|||..:   ...|..
  Fly  1188 QYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHP-GTLCTVIGWGKREDKDPKSTYE 1251

Human   761 LILQKGEIRVINQTTCENLLPQ-QITPRMMCVGFLSGGVDSCQGDSGGPL--SSVEADGRIFQAG 822
            .|:.:.::.:|.:..|:..|.. .::..|:|.||..||.|:|||||||||  .......|.|..|
  Fly  1252 YIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGG 1316

Human   823 VVSWGDGCAQRNKPGVYTRLPLFRDWIKE 851
            :||||..||....||||..:..:..||:|
  Fly  1317 IVSWGIMCAHPRLPGVYANVVQYVPWIQE 1345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ST14	NP_068813.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		SEA	88..>162	CDD:460188
		CUB	227..332	CDD:238001	31/117 (26%)
		CUB	340..444	CDD:238001	12/103 (12%)
		LDLa	454..486	CDD:238060	14/31 (45%)
		LDLa	488..523	CDD:238060	8/34 (24%)
		LDLa	525..559	CDD:238060	10/57 (18%)
		LDLa	567..602	CDD:238060	10/57 (18%)
		Tryp_SPc	615..852	CDD:238113	83/249 (33%)
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	40/160 (25%)
		LDLa	911..942	CDD:238060	14/31 (45%)
		LDLa	945..979	CDD:238060	8/47 (17%)
		SR	980..>1034	CDD:214555	12/56 (21%)
		Tryp_SPc	1104..1346	CDD:238113	83/249 (33%)