DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SSTR4 and AstC-R1

DIOPT Version :9

Sequence 1:	NP_001043.2	Gene:	SSTR4 / 6754	HGNCID:	11333	Length:	388	Species:	Homo sapiens
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	386	Identity:	132/386 - (34%)
Similarity:	211/386 - (54%)	Gaps:	41/386 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSAPSTLPPGGEEGL-GTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVG 64
            :|..||:.|  ||.| ||..|:          .:..:|....  .|.:..: .:|..||::||.|
  Fly    45 ISGSSTIQP--EESLYGTDLPT----------YQHCIATRNS--FADLFTV-VLYGFVCIIGLFG 94

Human    65 NALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCRAVLSVDGLN 129
            |.|||:|:||::||:|.||||:||||||||.|::.:||:..:..:..|.||..:|:|.:....:.
  Fly    95 NTLVIYVVLRFSKMQTVTNIYILNLAVADECFLIGIPFLLYTMRICSWRFGEFMCKAYMVSTSIT 159

Human   130 MFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPARGGQ 194
            .|||...|.::|.|||:||.||:.:..||...:||:::...|..|.::.||:.::|.|.....|.
  Fly   160 SFTSSIFLLIMSADRYIAVCHPISSPRYRTLHIAKVVSAIAWSTSAVLMLPVILYASTVEQEDGI 224

Human   195 AVACNLQWP-----HPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGW--QQRRR 252
            ..:||:.||     |.  ...|::|||.|||..|:..|...|.|::.|:|:|..:.|.  :::||
  Fly   225 NYSCNIMWPDAYKKHS--GTTFILYTFFLGFATPLCFILSFYYLVIRKLRSVGPKPGTKSKEKRR 287

Human   253 SEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLI-------LSYANSCANPIL 310
            :.:|:|||||.|:.|::|||:|.::.|:..:........::.:.::       |.|:||..||||
  Fly   288 AHRKVTRLVLTVISVYILCWLPHWISQVALIHSNPAQRDLSRLEILIFLLLGALVYSNSAVNPIL 352

Human   311 YGFLSDNFRR-FFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGG------AGCMCPPL 364
            |.|||:|||: ||:...|:....:...  .:.||..:.....|.:||      :....|||
  Fly   353 YAFLSENFRKSFFKAFTCMNKQDINAQ--LQLEPSVFTKQGSKKRGGSKRLLTSNPQIPPL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SSTR4	NP_001043.2	7tmA_SSTR4	48..322	CDD:320639	109/288 (38%)
		TM helix 1	49..75	CDD:320639	12/25 (48%)
		TM helix 2	82..108	CDD:320639	15/25 (60%)
		TM helix 3	119..149	CDD:320639	11/29 (38%)
		TM helix 4	161..183	CDD:320639	6/21 (29%)
		TM helix 5	208..237	CDD:320639	11/28 (39%)
		TM helix 6	252..282	CDD:320639	14/29 (48%)
		TM helix 7	290..315	CDD:320639	10/31 (32%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	109/281 (39%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	96/260 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2578
eggNOG	1	0.900	-	-		E33208_3BCR0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3312
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000463
OrthoInspector	1	1.000	-	-		mtm8609
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3938
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.990