DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SSTR3 and AstC-R1

DIOPT Version :9

Sequence 1:	NP_001042.1	Gene:	SSTR3 / 6753	HGNCID:	11332	Length:	418	Species:	Homo sapiens
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	381	Identity:	141/381 - (37%)
Similarity:	211/381 - (55%)	Gaps:	55/381 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGS 113
            ::|..||::||.||:||||||||.:...:|||:||||||:|||.|::|:|||.....:..|.||.
  Fly    82 VLYGFVCIIGLFGNTLVIYVVLRFSKMQTVTNIYILNLAVADECFLIGIPFLLYTMRICSWRFGE 146

Human   114 LMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPV 178
            .||:..|....|..|||...|.:||.|||:||.||..|.|:||..:|:.|||..|..|||::|||
  Fly   147 FMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTLHIAKVVSAIAWSTSAVLMLPV 211

Human   179 VVFSGVPR---GMS-TCHMQWPEPAAAWRAG--FIIYTAALGFFGPLLVICLCYLLIVVKVRSAG 237
            ::::....   |:: :|::.||: |....:|  ||:||..|||..||..|...|.|::.|:||.|
  Fly   212 ILYASTVEQEDGINYSCNIMWPD-AYKKHSGTTFILYTFFLGFATPLCFILSFYYLVIRKLRSVG 275

Human   238 RRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGL-------Y 295
            .:....| :.:||:.|:|||:|:.|:::::|||:|.:    ::.|..:...||...|       :
  Fly   276 PKPGTKS-KEKRRAHRKVTRLVLTVISVYILCWLPHW----ISQVALIHSNPAQRDLSRLEILIF 335

Human   296 FLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRR-VRSQ---EPTVGPPEKTEEEDEEEE 356
            .|:.||.|:||..|||||.|||..|::.|.:.....::: :.:|   ||:|           ..:
  Fly   336 LLLGALVYSNSAVNPILYAFLSENFRKSFFKAFTCMNKQDINAQLQLEPSV-----------FTK 389

Human   357 DGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSST 412
            .|.:.|.|.|      |:.      ||..:.||         |||..|.....|:|
  Fly   390 QGSKKRGGSK------RLL------TSNPQIPP---------LLPLNAGNNNSSTT 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SSTR3	NP_001042.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		7tm_4	55..>158	CDD:304433	54/102 (53%)
		7tm_1	61..313	CDD:278431	110/264 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..418		19/81 (23%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	120/285 (42%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	110/264 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2578
eggNOG	1	0.900	-	-		E33208_3BCR0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3312
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000463
OrthoInspector	1	1.000	-	-		mtm8609
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3938
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.990