Protein Alignment SSTR2 and npr-24

DIOPT Version :10

• Sequence 1: NP_001041.1
• Gene: SSTR2 / 6752
• HGNCID: 11331
• Length: 369
• Species: Homo sapiens
• Sequence 2: NP_510833.3
• Gene: npr-24 / 187897
• WormBaseID: WBGene00020086
• Length: 373
• Species: Caenorhabditis elegans
• Alignment Length: 367
• Identity: 112/367 - (30%)
• Similarity: 179/367 - (48%)
• Gaps: 52/367 - (14%)

Human    27 STNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADEL 91
            :||..|.||....:.:.|.||  :.:..:||:..|..|:..|:.:..|:||:||||.|||:||.|
 Worm     4 NTNEQNFTEVIDPIKTVAHLT--WCLTALIGIPANLFVLAAIVYFRDMRTISNIYIFNLAVADLL 66

Human    92 FMLGLPF-LAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRR 155
            |:.|:|. |..|.:...|.:|..:|::.::.:.::||.|...:.::|.||||||..||:|..:|.
 Worm    67 FLCGIPVSLFAQSSHDGWIWGPIMCKLYISGNAVSQFASAVFIAILSFDRYLAVCRPIQSKSFRT 131

Human   156 PRTAKMITMAVWGVSLLVILPIMIYAGL-RSNQWGRS---SCTINWPGESGAWYTG--------- 207
            .:.|..:::|.|.:.:|.:.|:.::..| :|:..|.:   ||.:         :.|
 Worm   132 TQAAFALSVAAWIMVILEMTPLFLFVKLIKSSSAGEARGGSCML---------FVGNVTVLESAT 187

Human   208 --------------------FIIYTFILGFLVPLTIICLCYLFIIIKV--KSSGIRVGSSKRKKS 250
                                ||.|||.|.:|:||..:...|..||:|:  :...::...:..||.
 Worm   188 EMNETLLNEIEQNMLASRRFFISYTFALSYLIPLVAVWYFYFKIILKMCQRKRQMQTKRTATKKR 252

Human   251 EKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMF---DFVVVLTYANSCANPILY 312
            ..|||.|...:|..:..|||||:|...|..:.....:..|  :|   .|...|.|.||.|||.||
 Worm   253 TTKVTIMGLAIVISYTHCWLPFWIVQWSIEANLFEKSKYL--LFCCTHFAFALQYINSAANPFLY 315

Human   313 AFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETT 354
            .||||:|:|:.|.:|...|.......:.|...||.|::...|
 Worm   316 VFLSDSFQKNIQKLLRTAKPDKQIMLKNSTDPQDTSKMLNVT 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SSTR2	NP_001041.1	7tmA_SSTR2	44..323	CDD:320637	99/317 (31%)
		TM helix 1	45..71	CDD:320637	7/25 (28%)
		TM helix 2	78..104	CDD:320637	15/26 (58%)
		TM helix 3	115..145	CDD:320637	10/29 (34%)
		TM helix 4	157..179	CDD:320637	5/21 (24%)
		TM helix 5	205..234	CDD:320637	13/57 (23%)
		TM helix 6	249..279	CDD:320637	12/29 (41%)
		TM helix 7	291..316	CDD:320637	12/27 (44%)
npr-24	NP_510833.3	7tm_GPCRs	25..326	CDD:475119	96/311 (31%)
		TM helix 1	25..45	CDD:410628	5/19 (26%)
		TM helix 2	54..76	CDD:410628	13/21 (62%)
		TM helix 3	92..114	CDD:410628	3/21 (14%)
		TM helix 4	137..153	CDD:410628	3/15 (20%)
		TM helix 5	206..229	CDD:410628	9/22 (41%)
		TM helix 6	257..279	CDD:410628	9/21 (43%)
		TM helix 7	293..319	CDD:410628	12/25 (48%)