DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BRCA2 and brca2

DIOPT Version :10

Sequence 1:NP_000050.3 Gene:BRCA2 / 675 HGNCID:1101 Length:3418 Species:Homo sapiens
Sequence 2:NP_001103864.2 Gene:brca2 / 566758 ZFINID:ZDB-GENE-060510-3 Length:2874 Species:Danio rerio


Alignment Length:3673 Identity:974/3673 - (26%)
Similarity:1455/3673 - (39%) Gaps:1133/3673 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    12 FEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLAS 76
            ||.|..:.:: :|||::.:|||||:..|.  ..|.:.||.....|   ...|.|:.....:||.|
Zfish     2 FENFFHQIDR-ELGPLNPDWFEELNERAS--RDEGSAESSKAGEN---ESIKAPETSALASQLFS 60

Human    77 TPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQAD-DVSC-PLLNSCL 139
            ||.|||::...    |||            .::||.        |::.:.|: ::|. |...|  
Zfish    61 TPRIFKQRHFP----QSP------------DSIPNE--------KSQNEGANGELSAFPWTES-- 99

Human   140 SESPVVLQCTHVTPQRDKSVV----CGSLFHTPKFVKGRQTPKHISESLGAEVDPDMSWSSSLAT 200
              ||.:......:|:.|:|..    |..|..|||....| :.|.|||||||:::||:||:||..|
Zfish   100 --SPCLFGSAKDSPKFDRSSEKPRDCFGLLDTPKRSLAR-SAKQISESLGAQINPDLSWTSSFNT 161

Human   201 PPTLSSTVLIVRNEE--ASETVFPHDTTANVKSYFSNHDESLKKNDRFIASVTDSENTNQREAAS 263
            ||:::.||::...|:  ||.::.....:..|:..|    .||.|:.....::.....|......:
Zfish   162 PPSMTPTVILPTTEDRVASASILKDKESIFVRKLF----PSLSKDSENATTLKQDVVTKSESIEA 222

Human   264 HGFGK----TSGNSFKVNSC-KDHIGKSMPNVLED-EVYETVVDTSE--EDSFSLCFSKCRTKNL 320
            ...|:    :...|..::|. |..:    ||.:|| :|..||.:..:  ||..|:.||. .|..|
Zfish   223 DDLGEKTVCSPNESLDISSLWKQRV----PNAIEDGDVRNTVQNVLDGAEDVLSIFFSN-NTSAL 282

Human   321 QKVRT-SKTRKKIFHEANADECEKSKNQVKEKYSFVSEVEPNDTDPLDSNVANQKPFESGSDKIS 384
            :|::: .:.||:|   .|:.|..||       ....||.|    ..|.::...:.| ....|.| 
Zfish   283 RKIKSKERIRKRI---TNSSEDVKS-------VFLTSEPE----QKLKADTETKSP-SKNDDSI- 331

Human   385 KEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCDQNISEKDLLDTENKRKKDFLTSENSLPRI 449
                     ||:.|:||       |.|       ..:..|...|:|                   
Zfish   332 ---------EWTPLSLS-------ETI-------LTEGCSSTSLVD------------------- 354

Human   450 SSLPKSEKPLNEETVVNKRDEEQHLESHTDCILAVKQAISGTSPVASSFQGIKKSIFRIRESPKE 514
                      |..||                                              :|.|
Zfish   355 ----------NNNTV----------------------------------------------APSE 363

Human   515 TFNASFSGHMTDPNFKKETEASESGLEIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGL 579
            |.:.:.        ||..:|:|::               ||..:...|.|..|....:.|..:..
Zfish   364 TNDGAI--------FKFTSESSQT---------------CPQSVRLESSPEGTQCQKILLDKSSA 405

Human   580 ISTLKKKTNKFIYAIHDETSYKGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVK 644
            . .|.||..||:|                          |..::.....||.:.||         
Zfish   406 F-MLNKKPRKFVY--------------------------QVSSSEMSTTLTGSKAD--------- 434

Human   645 RSCSQNDSEEPTLSLTSSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSL 709
                                  |.||           :.|.|  ||.            |..:.|
Zfish   435 ----------------------LPKC-----------LDQTL--KEG------------PSVEEL 452

Human   710 S-CLQEGQCENDPKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTP 773
            | ||.:....|:                  :|:.      ..|..|:.:.|..:|          
Zfish   453 SVCLNKSSFTNE------------------NPIG------DQTQPQAVEQLSSEH---------- 483

Human   774 TSKDVLSNLVMISRGKESYKMSDKLKGNNYESDVEL--TKNIPMEKNQDVCALNENYKNVELLPP 836
                       :..|.:..::| |.....:..::..  ..::|::.||          .|::.|.
Zfish   484 -----------LDHGLDMTQLS-KAFAEEFTQEIMAGGLLDMPVQSNQ----------KVQVQPK 526

Human   837 EKYMRVASPSRKVQFNQNT---NLRVIQKNQ-EETTSISKITVNPDS--EELFSDNENNF----- 890
                  |.|..|.:...:|   ||..|..|. .::|||:...::.||  ...|||.:...     
Zfish   527 ------AEPESKNKDGNHTDISNLADISVNSPNKSTSITTFEISHDSGCPTTFSDLDRTTASFAD 585

Human   891 ------VFQVANERNNLALGNTKELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVY 949
                  .|:.||.:               ..|:.......:...|....||..|...:..|...:
Zfish   586 IGEYFPTFKTANNK---------------FICIPTEAIVKAKASLDEAAGDGLAKTSNQTKPKHF 635

Human   950 VLAEENKNSVKQHI---KMTLGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRT 1011
            .:.|....||.:.|   :..:||           .||                 |||:.|.|...
Zfish   636 HVTETMCKSVSRSIPAPRPPVGQ-----------SIP-----------------SNHASGVSVSD 672

Human  1012 ASNKEIKLSEHNIKKSKMFFKDI------EEQYPTSLACVEIVNTLALDNQKKL----------S 1060
            ||..:      :.|..||.|.:.      |....||...:..|:...|..:..|          |
Zfish   673 ASKTD------SPKGFKMNFSNCSLPQSDESDCKTSSKTIITVSDAGLQTESLLKEKLGRSSESS 731

Human  1061 KP-------------QSINTVSAHLQSSVVVSDCKNSHITPQMLFSKQDFNSNHNLTPSQKAEIT 1112
            ||             .::..:|:..:.:.|.|.|             .|...|..||.||||::|
Zfish   732 KPIHQKVDFERSAERHAVFDISSTQKPTAVDSSC-------------DDLEENGTLTASQKADVT 783

Human  1113 ELSTILEESGSQFEFTQFRKPSYILQKSTFEVPENQMTILKTTSEECRDADLHVIMNAPSIGQVD 1177
            ||.::|||:.||:||||:        |||.....|     :||.:|. |.|:        :..:|
Zfish   784 ELCSLLEEANSQYEFTQY--------KSTNIGSHN-----RTTEKEW-DPDI--------LNDID 826

Human  1178 SSKQFEGTVEIKRK-----------------FAGLLKNDCNKSASGYLTDENEV--GFR------ 1217
            ....|...| :|.|                 |...||...|.:....:|:|:.:  |.|      
Zfish   827 FDDSFSCDV-VKGKHPSKTNASSVNTSDLISFRSDLKEKQNGTVVLSVTEESALVDGMRSILSKS 890

Human  1218 ---------GFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISLSSSKCHDSVVSMF 1273
                     ||.:|.|..::||.::|.||...|.  |:..|.|...|  |:....|...||.:..
Zfish   891 SDNSHFHTFGFKTAKGKAISVSEKSLNKAKHFFE--EDYKEATFTGV--INQEHFKTESSVKTCI 951

Human  1274 KIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENEDNKYTAASRNSHNLEFDG 1338
            ..||:|.:|..:....|                            .|.|    |:.|..|.:..|
Zfish   952 STENNNAQTKQDVRLSC----------------------------GEVN----AAHNMINWQEAG 984

Human  1339 SDSSKNDTVCIHKDETDLL---------FTDQHNICLKLSGQFMKE-----------GNTQI--- 1380
            :..::.:  |: :|:||::         |:......||:|.:.:::           |.:|.   
Zfish   985 NAGTEPN--CL-RDKTDVVCVDSNIHFGFSTARGAKLKVSEKALEQARMFLNDVDSIGESQTPKL 1046

Human  1381 ------KEDLSDLTFLEVAKAQEACHGNTSNK----------------------------EQLTA 1411
                  |.|:| :....:.|.::.|.|.||.|                            ||.:.
Zfish  1047 VPRSSGKHDVS-MQSTRLQKTKDLCRGETSIKISQPDSGVANQISNGADITTFNSENVFQEQKSG 1110

Human  1412 TKTEQNIKDFETSDTF---------FQTASGKNISVAKESFNKIVNFFDQKPEELHNF-SLNSEL 1466
            ...::..:....|:|.         |||||||.:||...:..|....|......:.|. |.|.| 
Zfish  1111 NAAKEVCEKISPSETSMPQPQQGYGFQTASGKGVSVLPSALKKAKAIFKDCDSNIDNLQSTNME- 1174

Human  1467 HSDIRKNKMDILSYEETDIVKHKILKESVPVGTGNQLVTF---------------QGQPERD--- 1513
               .||.|:|:           :|:|::..:.:.::.|||               |..|:::   
Zfish  1175 ---ERKTKLDV-----------EIVKQTNALISNSKSVTFSDVEEFKTDLINNLDQEAPQKEVCE 1225

Human  1514 ---------EKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQG---------TSEITSFS 1560
                     ..|......||.|||||||.::.|:|.:.|::..|...|         |:::....
Zfish  1226 LKGLQSEFSNLISSNGNCGFSTASGKKVSVSAEALQRAKDVLFESVDGFSCANVYKKTNQVVDIQ 1290

Human  1561 HQWAKTLKYREAC-----------------KDLELACETIEITAAPKCKEMQNSL---------- 1598
            ...:.:.|::..|                 |:|...||...:|....||.:.|.|          
Zfish  1291 LDSSSSGKHKGFCTAGGKKVAFSATGLQKAKNLFRGCEEESLTTEQNCKGLSNVLMLACNGVSLI 1355

Human  1599 ----NNDKNLVSIETVVPPK----------------------LLSDNLCRQTENLKTSKSIFLKV 1637
                |:..|.|...|....|                      |.|.:|..|.....:.|::|:..
Zfish  1356 PEPGNSSGNNVGFSTAGGRKMDISVTALQKANNLFKDCEEESLASRSLAHQGFTTASGKNVFVSE 1420

Human  1638 KVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTSVSQTSLLEAKKWLREGIFDGQP 1702
            |....|....|....|.::.:.....:.|  :.|.|:..:|.::|.|||.......:    |.:.
Zfish  1421 KALSEVRAVFAGCDETSFSLELKKLSVNN--VGFSTAGGKKVTISDTSLQRTMNLFQ----DCEE 1479

Human  1703 ERINTAD--YVG--NYLYENNSNSTIAENDKNHLSEKQDTYLSNSSMSNSYSYHSDEVYNDSGYL 1763
            |.:.:..  :.|  .:...:..|.|::|   ..|||.:..:......|.|:              
Zfish  1480 ESLGSRSLKHQGCKGFTTASGKNVTVSE---KALSEVRAVFAGCDEASFSH-------------- 1527

Human  1764 SKNKLDSGIEPVLKNVEDQKNTSFSKVISNVKDANAYPQTVN--EDICVEELVTSSSPCKNKNAA 1826
                     ||  ||:...| ..||..:..:..|...|...|  :| |.||              
Zfish  1528 ---------EP--KNISGNK-IGFSTTVEKMTTALEMPNNNNNFKD-CEEE-------------- 1565

Human  1827 IKLSISNSNNFEVGPPAFRIASGKIVCVSHETIKKVKDIFTDSFSKVIKENNENKSKICQTKIMA 1891
               |:::.|........|..||||.|.||...:.:||.:|                        |
Zfish  1566 ---SLASRNLMHQACKGFTTASGKNVTVSETALNEVKAVF------------------------A 1603

Human  1892 GCYEALDDSEDILHNSLDNDECSTHSHKVFADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSD 1956
            ||.||..|.|.                                                      
Zfish  1604 GCDEATFDLEP------------------------------------------------------ 1614

Human  1957 ICKCSIGKLHKSVSSANTCGIFSTASGKSVQVSDASLQNARQVFSEIEDSTKQVF---------- 2011
              |.|:|         :..| ||||.||.|.:|..:||.|:.:|.:.|:. |:||          
Zfish  1615 --KKSLG---------SNIG-FSTAGGKKVTISSTALQRAQTLFKDCEEE-KEVFESEKAPLPTK 1666

Human  2012 -----SKVLFKSNEHSDQLTREENTAIRTPEHLISQKGFSYNVVNSSAFSGFSTASGKQVSILES 2071
                 |:.:...|...|| |.::|..:                         ||||||.||:.:.
Zfish  1667 SFHARSEDIVDGNLKFDQ-TNKKNPRL-------------------------STASGKVVSVTKV 1705

Human  2072 SLHKVKGVLEEFD---------LIRTEHSLHY-SPTSRQNVSKILPRVDKRNPEHCVNSEMEKTC 2126
            ||.:......|||         |:..:.|.|| ....||..:.:.|:..:..|.|.         
Zfish  1706 SLEETSTFFREFDNQNTATDNQLLLRDSSKHYPQHKDRQTKATLHPKAARNEPAHL--------- 1761

Human  2127 SKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQDKQQLVLGTKVSLVENIHVLGKEQASPKNVK 2191
                              :.||:..:..     .|.||:                          
Zfish  1762 ------------------DLHSLDFNSC-----TDTQQI-------------------------- 1777

Human  2192 MEIGKTETFSDVPVKTNIEVCSTYSKDSENYFETEAVEIAKAFMEDDELTDS------------K 2244
                                          |||.||:...||.:|||:|.:|            :
Zfish  1778 ------------------------------YFEQEAMACTKALLEDDDLIESAGLISSEDIDNKR 1812

Human  2245 LPSHATHSLFTCPENEEMVLSNSRIGKRR--GEPLILVGEPSIKRNLLNEFDRIIENQEKSLKAS 2307
            .||      |:..:..|.|..| |..||:  |..:...|:|.:||.||:||||.:..:...|...
Zfish  1813 RPS------FSDVQTIESVDQN-RKRKRQVDGSSVADSGQPPLKRQLLSEFDRTLHAKTSGLTPL 1870

Human  2308 KSTPDGTIKDRRLFMHHVSLEPITCVP--FRTTKERQEIQNPNFTAPGQEFLSKSHLYEHLTLEK 2370
            ||.|:||:||||:|.::|.|:|....|  |...::...|:....|...|:..:..|:.       
Zfish  1871 KSCPNGTLKDRRVFKYNVHLKPYVTSPVLFPVNQQSNNIEEHCSTESVQKRCNSDHMG------- 1928

Human  2371 SSSNLAVSGHPFYQVSATRNEKMRHLITTGRPTKVFVPPFKTKSHFHRVEQCV----RNINLEEN 2431
                 .|...||                    .|...||........:|...:    ..:|.|||
Zfish  1929 -----GVFNPPF--------------------QKNMNPPTSNSQDASKVSSGIVLSFNVVNQEEN 1968

Human  2432 RQKQNIDG----HGSDDSKNKINDNEIHQFNKNNSNQAVAVTFTKC----EEEPLDLITSLQNAR 2488
            ...:.:|.    ..|...:.|.|.||.:|.:|:.|:.:|.....|.    |::.:.|..|||.||
Zfish  1969 PNSKEMDQIMAISKSHCDRGKQNCNEKNQDSKSKSSSSVQSIPLKIGNFDEKDMIALQESLQLAR 2033

Human  2489 DIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYTYGVSKHCIKIN 2553
            |:||||::||:||.:.|.||||||||||.:.|.||:.|||...||..:..:|..:||....::|.
Zfish  2034 DMQDMRLRKKKRQTIRPVPGSLYLAKTSGVSRKSLRDAVGCTCPSQYTQDELSQHGVHHKVLEIT 2098

Human  2554 SKNAESFQFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRI 2618
            |:|||||:|...|||..|.|.....:||||||||:|.:.|..|||||:.||||||||||||||.:
Zfish  2099 SENAESFRFDCSDYFTCEHLMESGALQLADGGWLVPDSKGTVGKEEFFSALCDTPGVDPKLISDV 2163

Human  2619 WVYNHYRWIIWKLAAMECAFPKEFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAA 2683
            ||:|||||||||.|:||..||......||:||:||||||:|||.|:|.|:|||:::|||||||.|
Zfish  2164 WVFNHYRWIIWKRASMERTFPNLIGGLCLTPEQVLLQLKFRYDVEVDHSQRSALRRIMERDDTPA 2228

Human  2684 KTLVLCVSDIISLSANISETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVG 2748
            |||||||..|:....|..:|..:..|.:...:..:|.||||||::|:.|||||.|:|..|||.:|
Zfish  2229 KTLVLCVCGIVQTCQNPEKTMKDDKSPSAKMESCVIWLTDGWYSIKSLLDPPLSAMLNKGRLKIG 2293

Human  2749 QKIILHGAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGG 2813
            .||:..|||||||.:||.||||||||||||||||||.|||.||||::.||||..|.||||::.||
Zfish  2294 DKIVTSGAELVGSQEACPPLEAPESLMLKISANSTRRARWDTKLGYYRDPRPIRLLLSSLYASGG 2358

Human  2814 NVGCVDVIIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEE 2878
            .|.||::::.|:||.|||||..:.::||||:|.|::||.|:..::.|.|:.|.:|||.:||:..|
Zfish  2359 LVSCVNLLVLRSYPTQWMEKKPNSVFIFRNDRAEDREARKHSNSKHKSLDLLISKIQTQFEKEME 2423

Human  2879 NTTKPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKKQAQ 2943
            ...|.....|..:|.::..||||.|||||::   ..|.:|...|.:|:.|::.:|....:|:||:
Zfish  2424 GKKKKRAQRRTFSRHEIETLQDGDELYEAME---QDAAVETRLSHKQMEAVSKYRCCREEKRQAE 2485

Human  2944 IQLEIRKAMESAEQKEQGL-SRDVTTVWKLRIVSYSKKEKDSV-ILSIWRPSSDLYSLLTEGKRY 3006
            :|..::||:..|::.|.|. :||||.||||.::..|..:.:.| .|:||||:.:|..|||||.||
Zfish  2486 LQERVQKAVMEAQEAEGGCPNRDVTPVWKLSVIDASDMQSNCVYTLNIWRPTRELQGLLTEGHRY 2550

Human  3007 RIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKFLDPDFQPSCSE 3071
            |.||||:|:.|.:|..|:|||.|||||.:|.:.||.|.|.|.::.||.:.|.:..:|.|...|.|
Zfish  2551 RAYHLASSEGKKRSGVAHIQLTATKKTLFQDIEVSPEWLHQHFRARECVRFRELQNPHFSSPCGE 2615

Human  3072 VDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLN----EDIIKPHMLIAASNLQWRPESK 3132
            ||::|::||:..|.|..|.::|.||.::|:.::.:..|.    |:::||..|:|..|||.|..| 
Zfish  2616 VDIVGYIVSIEGKQGHCPVLHLVDENFDLVTVRTYSSLEQLAVEELVKPRALVAICNLQVRVLS- 2679

Human  3133 SGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKLMHILHANDPKWSTPTKD 3197
            ..:.:|:||:.::||.:|||.:.||....:|...:|.:...|.||.|:..::.:.          
Zfish  2680 GPVPSLYAGEQALFSINPKESYLQEAMAHLKTFAQNYEQFFNLAEEKVSDVVPSG---------- 2734

Human  3198 CTSGPYTAQIIPGTG-----NKLLMSSPNCEIYYQSPLSLCMAKRKSVSTPVSAQMTSKSCKGEK 3257
             ..|.:.:...||..     |..:.......|:  ||.:....:     ||.|   ||.|     
Zfish  2735 -VLGSFQSPRTPGVQPFPKMNGTVTPQQKSSIF--SPFTPLNRR-----TPAS---TSNS----- 2783

Human  3258 EIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQPPRSCGTKYETPIKKKELNSPQM 3322
            |:.|.||.|:||.||:|||:|.|||:.|:.|..||...|.|.|||    |..||...:...||..
Zfish  2784 EVKDSKNLKRRRGLDYLSRIPSPPPLIPLKTRASPCINKTFNPPR----KSVTPKPPQNECSPAS 2844

Human  3323 TPFKKFNEISLLESNSIADEELALINTQALLSG 3355
            .|       ...|...:.|||||:|:||||:.|
Zfish  2845 RP-------PAGEEKWVHDEELAMIDTQALVDG 2870

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BRCA2NP_000050.3 Interaction with PALB2 1..40 11/27 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 37..68 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 358..381 3/22 (14%)
Interaction with NPM1. /evidence=ECO:0000269|PubMed:21084279 639..1000 59/383 (15%)
BRCA2 1 1002..1036 10/39 (26%)
Interaction with RAD51. /evidence=ECO:0000250|UniProtKB:P97929 1003..2082 273/1318 (21%)
BRCA2 1005..1033 CDD:459881 8/27 (30%)
BRCA2 1216..1243 CDD:459881 11/41 (27%)
Interaction with POLH. /evidence=ECO:0000269|PubMed:24485656 1338..1781 115/602 (19%)
Required for stimulation of POLH DNA polymerization activity 1410..1595 53/247 (21%)
BRCA2 1424..1452 CDD:459881 13/36 (36%)
BRCA2 1522..1548 CDD:459881 12/25 (48%)
BRCA2 1667..1695 CDD:459881 7/27 (26%)
BRCA2 1974..2002 CDD:459881 13/27 (48%)
BRCA2 8 2051..2085 13/42 (31%)
BRCA2 2055..2082 CDD:459881 10/26 (38%)
Interaction with HSF2BP. /evidence=ECO:0000269|PubMed:31242413 2270..2337 29/70 (41%)
Interaction with FANCD2 2350..2545 61/206 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2430..2450 5/23 (22%)
Interaction with SEM1. /evidence=ECO:0000269|PubMed:10373512, ECO:0000269|PubMed:16205630 2481..2832 206/350 (59%)
BRCA-2_helical 2481..2667 CDD:462700 109/185 (59%)
BRCA-2_OB1 2670..2796 CDD:462678 76/125 (61%)
Nuclear export signal, masked by interaction with SEM1. /evidence=ECO:0000269|PubMed:24013206 2682..2698 9/15 (60%)
BRCA2DBD_OB2 2804..3054 CDD:239940 109/251 (43%)
BRCA-2_OB3 3052..3186 CDD:462679 46/137 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3393..3418
brca2NP_001103864.2 BRCA2 900..925 CDD:459881 10/26 (38%)
BRCA2 1009..1034 CDD:459881 4/24 (17%)
BRCA2 1135..1160 CDD:459881 11/24 (46%)
BRCA2 1244..1267 CDD:459881 12/22 (55%)
BRCA2 1300..1325 CDD:459881 3/24 (13%)
BRCA2 1367..1392 CDD:459881 2/24 (8%)
BRCA2 1407..1431 CDD:459881 4/23 (17%)
BRCA2 1451..1476 CDD:459881 7/28 (25%)
BRCA2 1492..1518 CDD:459881 6/28 (21%)
BRCA2 1577..1603 CDD:459881 11/49 (22%)
BRCA2 1620..1648 CDD:459881 13/28 (46%)
BRCA-2_helical 2026..2212 CDD:462700 109/185 (59%)
BRCA-2_OB1 2215..2341 CDD:462678 76/125 (61%)
BRCA2DBD_OB2 2350..2597 CDD:239940 108/249 (43%)
BRCA-2_OB3 2596..2733 CDD:462679 46/137 (34%)
Blue background indicates that the domain is not in the aligned region.

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