|
Human 1 MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTP 65
|.:..|.||||:||||.||:.||||||||||||||||||||||:||.||||:|...:||.|||||
Rat 1 MTVEYKRRPTFWEIFKARCSTADLGPISLNWFEELSSEAPPYNTEPPEESEYKPQGHEPQLFKTP 65
Human 66 QRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDV 130
||.|||:|.|||||:||||..||||.|||.|| ||..|.||:.|.....|.:.|...||
Rat 66 QRNPSYHQFASTPIMFKEQSQTLPLDQSPFKE-------LGNVVANSKRKHHSKKKARKDPVVDV 123
Human 131 SCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHISESLGAEVDPDMSWS 195
:...|.:|.||||...:||.|.|||.|.||.||||:|||. .:||||||||||.||||||||:
Rat 124 ASLPLKACPSESPCTPRCTQVAPQRRKPVVSGSLFYTPKL---EETPKHISESLGVEVDPDMSWT 185
Human 196 SSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESLKKNDRFIASVTDSENTNQRE 260
|||||||||||||||.|:|||....||.|:.|::|||||||:||||||||||.||:||||.:|:|
Rat 186 SSLATPPTLSSTVLIARDEEAHRNAFPADSPASLKSYFSNHNESLKKNDRFIPSVSDSENKSQQE 250
Human 261 AASHGFGKTSG-NSFKVNSCKDHIGKSMPNVLEDEVYETVVDTSEEDSFSLCFSKCRTKNLQKVR 324
|.|.|..|..| :|.|:|..:|.:.|.:||||||. ||.||||.||||||||.|.||:||||.|
Rat 251 AFSQGLEKMLGDSSSKINRFRDCLRKPIPNVLEDG--ETAVDTSGEDSFSLCFPKRRTRNLQKTR 313
Human 325 TSKTRKKIFHEANADE-CEKSKNQVKEKYSFVSEVEPNDTDPLDSNVANQKPFESGSDKISKEVV 388
..|.:||||.|...|. .|:::.|..:|.||..|:||.|::|||.:|.||||..|.|..||.|..
Rat 314 MGKMKKKIFSETRTDGLSEEARGQADDKNSFALEIEPRDSEPLDPSVTNQKPLYSQSGDISSEAG 378
Human 389 PSLACEWSQLTLSGLNGAQMEKIPLLHISSCDQNISEKDLLDTENKRKKDFLTSENSLPRISSLP 453
......|||...|||||.|..|||||||||..|:|.| |.:|.:.:. |...:.|.|||||
Rat 379 QCSDSIWSQPDPSGLNGTQTRKIPLLHISSHKQSILE-DFIDMKKEG-----TGSITFPHISSLP 437
Human 454 KSEKPLNEETVVNKRDEEQHLESHTDCILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNA 518
:.||..:|||:|:|..|.|||||..|.| :.||.:||||..|.....|:|||.::||..:||.:.
Rat 438 EPEKMFSEETLVDKEHEGQHLESLEDSI-SGKQMVSGTSQTACLSPSIRKSIVKMREPLEETLDT 501
Human 519 SFSGHMTDPNFKKETEASESGLEIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTL 583
.||..||...|.:|.:||..||||||.|||:||||||:.:|.||||.|.|..|..:||||||:||
Rat 502 VFSDSMTSSAFTEELDASAGGLEIHTACSQREDSLCPSSVDTGSWPTTLTDTSATVKNAGLITTL 566
Human 584 KKKTNKFIYAIHDETSYKGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCS 648
|.|..||||::.|:.|::|||:...::|||.|.||.|||:|||.|..|.|.|||:..||:|||..
Rat 567 KNKRRKFIYSVSDDASHQGKKLQTQRQSELTNLSAPFEASAFEVPFPFTNVDSGIPDSSIKRSNL 631
Human 649 QNDSEEPTLSLTSSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQ 713
.||.|||:||||:||.|...| |....:.:|||||:.|||..::||.|.:...|||.||||.
Rat 632 PNDPEEPSLSLTNSFVTAASK----EISYIHALISQDLNDKEAILSEEKPQPYTALEADFLSCLP 692
Human 714 EGQCENDPKSKKVSDIKEEVLAAACHPVQH--SKVEYSDTDFQSQKSLLYDHENASTLILTPTSK 776
|..||||.||.||||.||:||.:||.|... :.|:.|...|.||::.|..|...|||.|||:.|
Rat 693 ERSCENDQKSPKVSDRKEKVLVSACRPSGRLAAAVQLSSISFDSQENPLGSHNVTSTLKLTPSPK 757
Human 777 DVLSNLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYMR 841
..||..|::|||| ..||.:||:..:.:.::||:||||:..| ::|.|:||.:..|||||.:|:.
Rat 758 TPLSKPVVVSRGK-MCKMPEKLQCKSCKDNIELSKNIPLGVN-EMCVLSENSETPELLPPLEYIT 820
Human 842 VASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNNLALGNT 906
..|.|.|.||||||.:.|:||:|:::|.||::||:.:|||||.:.||||.|||.||.|...:|:|
Rat 821 EVSSSVKSQFNQNTKIAVVQKDQKDSTFISEVTVHMNSEELFPEKENNFAFQVTNESNKPNIGST 885
Human 907 KELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKD-----LVYVLAEENKNSVKQHIKMT 966
.|..|.||:.......|||.|.:..|..|:||.||.|.:| :|:...::::|:::||.|.|
Rat 886 VEFQEEDLSHTKGHSLKNSPMTVDRDLDDEQAGQVLITEDSDSLAVVHDCTKKSRNTIEQHQKGT 950
Human 967 LGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLSEHNIKKSKMFF 1031
..:|.||:.||.:.. :.||||::||:..|.|:.||.|||||||||||||||||.|:|||||||
Rat 951 ADKDFKSNSSLYLKS--DGNNDYLDKWSEFLDPLMNHKFGGSFRTASNKEIKLSEDNVKKSKMFF 1013
Human 1032 KDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSIN-----TVS--AHLQSSVVVSDCKNSHITPQ 1089
|||||||||||.|::.|:||.|.|:|:||:|.:.: ||| .|.||||...| :|..||
Rat 1014 KDIEEQYPTSLDCIDTVSTLQLANKKRLSEPHTFDLKSGTTVSTQCHSQSSVSHED---THTAPQ 1075
Human 1090 MLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKSTFEVPENQMTILKT 1154
||.|||||:|:||||||||||||||||||||||||||||||:.||:|.|.:|..|..|||.:::|
Rat 1076 MLSSKQDFHSSHNLTPSQKAEITELSTILEESGSQFEFTQFKNPSHIAQNNTSAVLGNQMAVVRT 1140
Human 1155 TSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDCNKSASGYLTDENEVGFRGF 1219
.|||.:|.|||:.:|..|:||:|.:|:||..|.:|:..:.||::.||::.|.:|..: |:.|.||
Rat 1141 ASEEWKDVDLHLPLNPSSVGQIDHNKKFECLVGVKQSSSHLLEDTCNQNTSCFLPIK-EMEFGGF 1204
Human 1220 YSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISLSSSKCHDSVVSMFKIENHN-DKTV 1283
.||.||||:||.|||:||:||||||||||||.|.:|.|...||...||||.|:|||:..| ||:.
Rat 1205 CSALGTKLSVSNEALRKAMKLFSDIENISEEPSTKVGPRGFSSCAHHDSVASVFKIKKQNTDKSF 1269
Human 1284 SEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENEDNKYTAASRNSHNLE-FDGSDSSKNDTV 1347
.||::|||:.:|||.||||...|:|..|||.:|.: :||.||.:.||::.|| .|.|.||.:.||
Rat 1270 DEKSSKCQVTVQNNKEMTTCILVDENPENYVKNIK-QDNNYTGSQRNAYKLENSDVSKSSTSGTV 1333
Human 1348 CIHKDETDLLF-TDQHNICLKLSGQFMKEGNTQIKEDLSDLTFLEVAKAQEACHGNTSNKEQLTA 1411
.|:|.::||.| .::.|...:...|:::|.|.||||.:||||.|||.||:|.||..:|:||||.:
Rat 1334 YINKGDSDLPFAAEKGNKYPESCTQYVREENAQIKESVSDLTCLEVMKAEETCHMKSSDKEQLPS 1398
Human 1412 TKTEQNIKDFETSDTFFQTASGKNISVAKESFNKIVNFFDQKPEEL--HNFSLNSELHSDIRKNK 1474
.|.|||:|:|..| |||||||||.|:|||.||.||..||:.|:| .:.||||::...|.|:|
Rat 1399 DKMEQNMKEFNIS---FQTASGKNIRVSKESLNKSVNILDQETEDLTVTSDSLNSKILCGINKDK 1460
Human 1475 MDILSYEETDIVKHKILKESVPVGTGNQLVTFQGQPERD-EKIKEPTLLGFHTASGKKVKIAKES 1538
|.|..::::..:| |:.:|..|:||.:||...|..||.: |.|||||||.|||||||||||.:||
Rat 1461 MHISCHKKSINIK-KVFEEHFPIGTVSQLPALQQYPEYEIESIKEPTLLSFHTASGKKVKIMQES 1524
Human 1539 LDKVKNLFDEKEQGTSEITSFSHQWAKTLKYREACKD-LELACETIEITAAPKCKEMQNSLNNDK 1602
|||||||||| .|...:.|:|.||.:|.||.||..|: |.||.|.||:||: ||:|||
Rat 1525 LDKVKNLFDE-TQYVRKTTNFGHQESKPLKDREDYKERLTLAYEKIEVTAS-KCEEMQ------- 1580
Human 1603 NLVSIETVVPPKLLSDNLCRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENS 1667
|.||.:|.:.|: .:|::.||||||.::.| ..|||.|:|.:..|:|..|...||.|.|.|:|
Rat 1581 NFVSKQTEMLPQ-QNDHMYRQTENLTSNGS---SPKVHGNIENKIEKNPRICCICQSSYFVTEDS 1641
Human 1668 ALAFYTSCSRKTSVSQTSLLEAKKWLRE--------GIFDGQPERINTADYVGNYLYENNSNSTI 1724
|||.||..||||.|.::||.:.|||||| ...:.|..:.:|.|:.||.|||::.....
Rat 1642 ALACYTGDSRKTCVGESSLSKGKKWLREQSDKLGTRNTIEIQCVKEHTEDFAGNALYEHSLVIIR 1706
Human 1725 AENDKNHLSEKQ-DTYLSNSSMSNSYSYHS-----DEVYNDSGYLSKNKLDSGIEPVLKNVEDQK 1783
.|.|.:|:||.| .|..|:.::.:||..|| |:::|||||..|:|:||.::|.:||.|.
Rat 1707 TEIDTSHVSENQASTLFSDPNVCHSYLSHSSFCHHDDMHNDSGYFLKDKIDSDVQPDMKNTEG-- 1769
Human 1784 NTSFSKVISNVKDANAYPQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRIAS 1848
|..|.| ||..|:...:||||||: ||::|.|::||..|||.||..::.:..|.:||.|.|
Rat 1770 NAIFPK-ISATKEIKLHPQTVNEE-CVQKLETNASPYANKNIAIDSAMLDLRNCKVGSPVF---- 1828
Human 1849 GKIVCVSHETIKKVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDNDEC 1913
|...|.||: ::|:||||:.||::::|.|:|...||| .|::|||:|||.:..|...|.|
Rat 1829 --ITTHSQETV-RMKEIFTDNCSKIVEQNRESKPDTCQT----SCHKALDNSEDFICPSSSGDVC 1886
Human 1914 STHSHKVFADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCGIF 1978
......:|.. |||:||||||::|||:|.: :| .|||||.|.|| ||....:.|..:.|.|||
Rat 1887 INSPMAIFYP-QSEQILQHNQSVSGLKKAA--TP-PVSLETWDTCK-SIRGSPQEVHPSRTYGIF 1946
Human 1979 STASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLISQK 2043
||||||:||||||||:.||||||||:...||:.|.|..:.||.|....:.|::.:.....::|.:
Rat 1947 STASGKAVQVSDASLEKARQVFSEIDGDAKQLASMVSLEGNEKSHHSVKRESSVVHNTHGVLSLR 2011
Human 2044 GFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQNVSKILPR 2108
......|:||.|||||||.||.|::.||:||||||:|||||||||||:|.:|||. ::||||.|:
Rat 2012 KTLPGNVSSSVFSGFSTAGGKLVTVSESALHKVKGMLEEFDLIRTEHTLQHSPTP-EDVSKIPPQ 2075
Human 2109 --VDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQDKQ-QLVLGTK 2170
::.|.||:.|:|:::||.:.:.:..:|.. |.|||.|..|::|||.|||.::.:: |.|||||
Rat 2076 PCLESRTPEYSVSSKLQKTYNDKSRSPSNYK-ESGSSGNTQSLEVSPQLSQMERKQETQSVLGTK 2139
Human 2171 VSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSENYFETEAVEIAKAFM 2235
|| ....::|.|:|..|:|:|:|..|.||||||.:||| |...|||:.||||||||||||||||
Rat 2140 VS-QRKTNILEKKQNLPQNIKIESNKMETFSDVSMKTN--VGEYYSKEPENYFETEAVEIAKAFM 2201
Human 2236 EDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILVGEPSIKRNLLNEFDRIIENQ 2300
||||||||: .:||..|||.||:|| .|.|||..||.|...:.||:|.|||:||||||||||::
Rat 2202 EDDELTDSE-QTHAKCSLFACPQNE--ALLNSRTRKRGGMAGVAVGQPPIKRSLLNEFDRIIESK 2263
Human 2301 EKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKERQEIQNPNFTAPGQEFLSKSHLYEH 2365
.|||..|||||||||||||||.||:||||:||.||.::|||||.|:|:.|:|.|...||.|...|
Rat 2264 GKSLTPSKSTPDGTIKDRRLFTHHMSLEPVTCGPFCSSKERQETQSPHVTSPAQGLQSKGHPSRH 2328
Human 2366 LTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTGRPTKVFVPPFKTKSHFHRVEQC-VRNINLE 2429
..:.|||||.. |||.|:|:.||.: :.:.|||||||||.||.|||.|.. .:|:|||
Rat 2329 SAVGKSSSNPT--------VSALRSERTRHSV-SDKSTKVFVPPFKVKSRFHRDEHFDSKNVNLE 2384
Human 2430 ENRQKQNIDGHGSDDSKNKINDNEIHQFNKNNSNQAVAVTFTKCEEEPLDLITSLQNARDIQDMR 2494
...|| :.||...|. ||::..|||| ||::|||||||:||:|
Rat 2385 GKNQK-SADGVSEDG-----NDSDFPQFNK-------------------DLMSSLQNARDLQDIR 2424
Human 2495 IKKKQRQRVFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAES 2559
||.|:|..:.||||||||.|:||||||||:||||..||||||.||||.|||||.||.:||||||.
Rat 2425 IKNKERHHLCPQPGSLYLTKSSTLPRISLQAAVGDSVPSACSPKQLYMYGVSKACISVNSKNAEY 2489
Human 2560 FQFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHY 2624
|||..||:||||:|..|||.:||||||||||:|||||||||||||||||||||||||.:||.|||
Rat 2490 FQFAIEDHFGKEALCAGKGFRLADGGWLIPSDDGKAGKEEFYRALCDTPGVDPKLISSVWVSNHY 2554
Human 2625 RWIIWKLAAMECAFPKEFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLC 2689
|||:|||||||.|||||||||||:|||||||||||||.|||.|.|||:|||:|||||||||||||
Rat 2555 RWIVWKLAAMEFAFPKEFANRCLNPERVLLQLKYRYDVEIDNSSRSALKKILERDDTAAKTLVLC 2619
Human 2690 VSDIISLSANISETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILH 2754
||||||||.|:||||.:|.||.|:.||..||||||||||||||||||||::|:||||||||||..
Rat 2620 VSDIISLSTNVSETSGSKASSEDSNKVDTIELTDGWYAVKAQLDPPLLALVKSGRLTVGQKIITQ 2684
Human 2755 GAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVD 2819
|||||||||||.|||||:||.|||||||||||||::|||||.|||||||||||||||||||||||
Rat 2685 GAELVGSPDACAPLEAPDSLRLKISANSTRPARWHSKLGFFHDPRPFPLPLSSLFSDGGNVGCVD 2749
Human 2820 VIIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENTTKPY 2884
||:||.||:||:|||.||.|||||||||||||.::.|||||:|||||||:..|.:||||:..:..
Rat 2750 VIVQRVYPLQWVEKTVSGSYIFRNEREEEKEALRFAEAQQKKLEALFTKVHTELKEHEEDIAQRR 2814
Human 2885 LPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGY----------------------------- 2920
:.|||||||||.|||||||||.||::|:||.:||.|
Rat 2815 VLSRALTRQQVHALQDGAELYAAVQDASDPEHLEVYSALTGGRPARVGRTAAASAVSQCVKCPQT 2879
Human 2921 -FSEEQLRALNNHRQMLNDKKQAQIQLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDS 2984
|||||||||||:||||:|||||:||.|.|||:|:|| ||:||||||:||||||:.||.|:|| |
Rat 2880 CFSEEQLRALNNYRQMLSDKKQARIQSEFRKALEAAE-KEEGLSRDVSTVWKLRVTSYKKREK-S 2942
Human 2985 VILSIWRPSSDLYSLLTEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIY 3049
.:||||||||||.||||||:|||||||:.||||:|.|..:|||.|||:|||||||||.|.|.|:|
Rat 2943 ALLSIWRPSSDLPSLLTEGQRYRIYHLSVSKSKNKFEWPSIQLTATKRTQYQQLPVSSETLLQLY 3007
Human 3050 QPREPLHFSKFLDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDII 3114
||||.|.|||..||.|||.|||||::|.||||||..||||.|||||||.:||.:||.|||||| |
Rat 3008 QPRELLPFSKLSDPAFQPPCSEVDVVGVVVSVVKPIGLAPLVYLSDECLHLLVVKFGIDLNED-I 3071
Human 3115 KPHMLIAASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENK 3179
||.:|||||||||||||.|.:.|||||:||||||||||.||||....||:.:||||....|||.|
Rat 3072 KPRVLIAASNLQWRPESTSRVPTLFAGNFSVFSASPKEAHFQERVTNMKHAIENIDTFYKEAEKK 3136
Human 3180 LMHILHANDPKWSTPTKDCTSGPYTAQIIP----GTGNKLLMSSPNCEIYYQSPLSLCMAKRKSV 3240
|:.:|..:.||||||.||.|..||.|.... .:|.:|..|||..:..|:||||.|....||.
Rat 3137 LIQVLKGDSPKWSTPNKDPTREPYPASTCSASDLASGGQLPRSSPTDQQSYRSPLSCCTPTGKST 3201
Human 3241 STPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQPPRSCG 3305
....||.|.:|||.||.||:|.|.|:|:||||.|||||||||:||:|||||||||||||||||||
Rat 3202 PLAHSAWMAAKSCSGENEIEDPKTCRKKRALDLLSRLPLPPPLSPVCTFVSPAAQKAFQPPRSCG 3266
Human 3306 TKYETPIKKKELNSP-QMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSEST 3369
|||.||:||:..:|| ...||:|.:.:|||:.:|:|||||||::||||:..|.|..:.:..|:||
Rat 3267 TKYPTPLKKEGPSSPWSRAPFQKASGVSLLDCDSVADEELALLSTQALVPHSVGGSEQVFPSDST 3331
Human 3370 RTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTK 3415
||...|:....|...| |.:.|..:|..:....:..:
Rat 3332 RTEGPSASTEARPANR----------SKRESLRDCRDDSDGKLAAE 3367
| 
