DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BRCA2 and Brca2

DIOPT Version :10

Sequence 1:NP_000050.3 Gene:BRCA2 / 675 HGNCID:1101 Length:3418 Species:Homo sapiens
Sequence 2:NP_033895.2 Gene:Brca2 / 12190 MGIID:109337 Length:3329 Species:Mus musculus


Alignment Length:3441 Identity:1972/3441 - (57%)
Similarity:2424/3441 - (70%) Gaps:186/3441 - (5%)


- Green bases have known domain annotations that are detailed below.


Human     1 MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTP 65
            ||:..|.||||:||||.||:.|||||||||||||||||||||||||.||||:|.:.|||.|||||
Mouse     1 MPVEYKRRPTFWEIFKARCSTADLGPISLNWFEELSSEAPPYNSEPPEESEYKPHGYEPQLFKTP 65

Human    66 QRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDV 130
            ||.|.|:|.|||||:|||:..||||.|||.:|       ||:.|.:|:||:....|||:|...||
Mouse    66 QRNPPYHQFASTPIMFKERSQTLPLDQSPFRE-------LGKVVASSKHKTHSKKKTKVDPVVDV 123

Human   131 SCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHISESLGAEVDPDMSWS 195
            :.|.|.|||||||:.|:||....||:|.||.||||:|||..:| ||||.||||||.||||||||:
Mouse   124 ASPPLKSCLSESPLTLRCTQAVLQREKPVVSGSLFYTPKLKEG-QTPKPISESLGVEVDPDMSWT 187

Human   196 SSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESLKKNDRFIASVTDSENTNQRE 260
            |||||||||||||||.|:|||..:|.|.|:.|.:||.||||:||.:||||.:.||.||||.||:|
Mouse   188 SSLATPPTLSSTVLIARDEEARSSVTPADSPATLKSCFSNHNESPQKNDRSVPSVIDSENKNQQE 252

Human   261 AASHGFGKTSGNSF-KVNSCKDHIGKSMPNVLEDEVYETVVDTSEEDSFSLCFSKCRTKNLQKVR 324
            |.|.|.||..|:|. |.||.||.:.|.:||:|||.  ||.|||||||||||||.|.||:||||:|
Mouse   253 AFSQGLGKMLGDSSGKRNSFKDCLRKPIPNILEDG--ETAVDTSEEDSFSLCFPKRRTRNLQKMR 315

Human   325 TSKTRKKIFHEANADE-CEKSKNQVKEKYSFVSEVEPNDTDPLDSNVANQKPFESGSDKISKEVV 388
            ..|||||||.|...|| .|:::.|..:|.|||.|:|..::||||..|.:||||.|.:::|..|.|
Mouse   316 MGKTRKKIFSETRTDELSEEARRQTDDKNSFVFEMELRESDPLDPGVTSQKPFYSQNEEICNEAV 380

Human   389 PSLACEWSQLTLSGLNGAQMEKIPLLHISSCDQNISEKDLLDTENKRKKDFLTSENSLPRISSLP 453
            ......|||..|||||..|..||.|.||||..||||| |.:|.: |.....:|||.|||.|||||
Mouse   381 QCSDSRWSQSNLSGLNETQTGKITLPHISSHSQNISE-DFIDMK-KEGTGSITSEKSLPHISSLP 443

Human   454 KSEKPLNEETVVNKRDEEQHLESHTDCILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNA 518
            :.||..:|||||:|..|.||.||..|.| |.||.:|.||..|.....|:||||::||...||...
Mouse   444 EPEKMFSEETVVDKEHEGQHFESLEDSI-AGKQMVSRTSQAACLSPSIRKSIFKMREPLDETLGT 507

Human   519 SFSGHMTDPNFKKETEASESGLEIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTL 583
            .||..||:..|.:|.|||..||.|.|.|||:|||:||:.:|.||||.|.|..|..:|||||||||
Mouse   508 VFSDSMTNSTFTEEHEASACGLGILTACSQREDSICPSSVDTGSWPTTLTDTSATVKNAGLISTL 572

Human   584 KKKTNKFIYAIHDETSYKGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCS 648
            |.|..||||::.|:.|.:|||:...::.||.|.|||.||:|||.||||.|.:||:..||.|:.|.
Mouse   573 KNKKRKFIYSVSDDASLQGKKLQTHRQLELTNLSAQLEASAFEVPLTFTNVNSGIPDSSDKKRCL 637

Human   649 QNDSEEPTLSLTSSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQ 713
            .||.|||  |||:||||...|    |....:.:|||||:.|||...:||.|.:...|||.|.||.
Mouse   638 PNDPEEP--SLTNSFGTATSK----EISYIHALISQDLNDKEAIVIEEKPQPYTAREADFLLCLP 696

Human   714 EGQCENDPKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDV 778
            |..||||.||.|||:.||:||.:||.|   |.|:.|...|:||::.|.||...|||.|||:||..
Mouse   697 ERTCENDQKSPKVSNGKEKVLVSACLP---SAVQLSSISFESQENPLGDHNGTSTLKLTPSSKLP 758

Human   779 LSNLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPP-EKYMRV 842
            ||...|:||.| ..||.:||:..:.:.::||:||| :|.| ::|.|:||.|...|||| |..:.|
Mouse   759 LSKADMVSREK-MCKMPEKLQCESCKVNIELSKNI-LEVN-EICILSENSKTPGLLPPGENIIEV 820

Human   843 ASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNNLALGNTK 907
            || |.|.|||||..: ||||:|:.:..||::.||.:|||||.|:.|||.|||.|:.|...||::.
Mouse   821 AS-SMKSQFNQNAKI-VIQKDQKGSPFISEVAVNMNSEELFPDSGNNFAFQVTNKCNKPDLGSSV 883

Human   908 ELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKD-----LVYVLAEENKNSVKQHIKMTL 967
            ||.|.||:....|..|||.|.:..|..|..|.||.|.||     :|:...|:::|:::||.|.|.
Mouse   884 ELQEEDLSHTQGPSLKNSPMAVDEDVDDAHAAQVLITKDSDSLAVVHDYTEKSRNNIEQHQKGTE 948

Human   968 GQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLSEHNIKKSKMFFK 1032
            .:|.||:.|||:..  :.|:|..:||:..|.|:.||:|||||||||||||||||||:||||||||
Mouse   949 DKDFKSNSSLNMKS--DGNSDCSDKWSEFLDPVLNHNFGGSFRTASNKEIKLSEHNVKKSKMFFK 1011

Human  1033 DIEEQYPTSLACVEIVNTLALDNQKKLSKP-----QSINTVS--AHLQSSVVVSDCKNSHITPQM 1090
            ||||||||.|||::|||||.|.||||||:|     :|:.|||  :|.||||...|   :...|||
Mouse  1012 DIEEQYPTRLACIDIVNTLPLANQKKLSEPHIFDLKSVTTVSTQSHNQSSVSHED---TDTAPQM 1073

Human  1091 LFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKSTFEVPENQMTILKTT 1155
            |.|||||:|| |||.|||||||||||||||||||||||||||||:|.| :|.|||.|||.:|.|.
Mouse  1074 LSSKQDFHSN-NLTTSQKAEITELSTILEESGSQFEFTQFRKPSHIAQ-NTSEVPGNQMVVLSTA 1136

Human  1156 SEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDCNKSASGYLTDENEVGFRGFY 1220
            |:|.:|.|||:.:: ||:||.|.||||||:..:|:.|..||::.|||:.|.:|.:.||:.|.||.
Mouse  1137 SKEWKDTDLHLPVD-PSVGQTDHSKQFEGSAGVKQSFPHLLEDTCNKNTSCFLPNINEMEFGGFC 1200

Human  1221 SAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISLSSSKCHDSVVSMFKIENHN-DKTVS 1284
            ||.||||:||.|||:||:|||||||| |||.||:|.|...|||..||||.|:|||:..| :|:..
Mouse  1201 SALGTKLSVSNEALRKAMKLFSDIEN-SEEPSAKVGPRGFSSSAHHDSVASVFKIKKQNTEKSFD 1264

Human  1285 EKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENEDNKYTAASRNSHNLE-FDGSDSSKNDTVC 1348
            ||::|||:.|||||||||..||....|.|.:||::||: ||::.||  ||| .|||.||.:..|.
Mouse  1265 EKSSKCQVTLQNNIEMTTCIFVGRNPEKYIKNTKHEDS-YTSSQRN--NLENSDGSMSSTSGPVY 1326

Human  1349 IHKDETDLLFTDQHNICLKLSGQFMKEGNTQIKEDLSDLTFLEVAKAQEACHGNTSNKEQLTATK 1413
            |||.::||. .||.:.|.:...|:.:|.||||||::||||.||:.||:|.|. .:|:|:||.:.|
Mouse  1327 IHKGDSDLP-ADQGSKCPESCTQYAREENTQIKENISDLTCLEIMKAEETCM-KSSDKKQLPSDK 1389

Human  1414 TEQNIKDFETSDTFFQTASGKNISVAKESFNKIVNFFDQKPEELH--NFSLNSELHSDIRKNKMD 1476
            .|||||:|..|   ||||||||..|:|||.||.||.|:::.:||.  :.||||::...|.|:||.
Mouse  1390 MEQNIKEFNIS---FQTASGKNTRVSKESLNKSVNIFNRETDELTVISDSLNSKILHGINKDKMH 1451

Human  1477 ILSYEETDIVKHKILKESVPVGTGNQLVTFQGQPERD-EKIKEPTLLGFHTASGKKVKIAKESLD 1540
            ...:::...:| |:.::..|:.|.:||.. |..||.: |..||||||.|||||||||||.:||||
Mouse  1452 TSCHKKAISIK-KVFEDHFPIVTVSQLPA-QQHPEYEIESTKEPTLLSFHTASGKKVKIMQESLD 1514

Human  1541 KVKNLFDEKEQGTSEITSFSHQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLV 1605
            |||||||| .|...:..||| |.:|.||  ::.|:|.||.|.||:||: ||:|||       |.|
Mouse  1515 KVKNLFDE-TQYVRKTASFS-QGSKPLK--DSKKELTLAYEKIEVTAS-KCEEMQ-------NFV 1567

Human  1606 SIETVVPPKLLSDNLCRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALA 1670
            |.||.:.|: .:.::.|||||||||..  ...||.||:|....|:|..|...||.|.|.|:||||
Mouse  1568 SKETEMLPQ-QNYHMYRQTENLKTSNG--TSSKVQENIENNVEKNPRICCICQSSYPVTEDSALA 1629

Human  1671 FYTSCSRKTSVSQTSLLEAKKWLREGIFDGQPERI-------------NTADYVGNYLYENNSNS 1722
            :||..||||.|.::||.:.:|||||     |.:::             :|.|:.||..||::...
Mouse  1630 YYTEDSRKTCVRESSLSKGRKWLRE-----QGDKLGTRNTIKIECVKEHTEDFAGNASYEHSLVI 1689

Human  1723 TIAENDKNHLSEKQ-DTYLSNSSMSNSY----SY-HSDEVYNDSGYLSKNKLDSGIEPVLKNVED 1781
            ...|.|.||:||.| .|.||:.::.:||    |: |.|:::|||||..|||:||.:.|.:||.| 
Mouse  1690 IRTEIDTNHVSENQVSTLLSDPNVCHSYLSQSSFCHCDDMHNDSGYFLKNKIDSDVPPDMKNAE- 1753

Human  1782 QKNTSFSKVISNVKDANAYPQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRI 1846
              ..:.|..:|..|:.|.:|||:|| .||::|.|::||..||:.||..|:.:|.|.:||...|  
Mouse  1754 --GNTISPRVSATKERNLHPQTINE-YCVQKLETNTSPHANKDVAIDPSLLDSRNCKVGSLVF-- 1813

Human  1847 ASGKIVCVSHETIKKVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDND 1911
                |...|.|| ::.|:|.||:..|::::|.::|...|||    .|::.||||:|.:..|...|
Mouse  1814 ----ITAHSQET-ERTKEIVTDNCYKIVEQNRQSKPDTCQT----SCHKVLDDSKDFICPSSSGD 1869

Human  1912 ECSTHSHKVFADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCG 1976
            .|.......|.. .:|:||||||:||||:|.:  :| .|.|||.|..| ||.:..::...:.|.|
Mouse  1870 VCINSRKDSFCP-HNEQILQHNQSMSGLKKAA--TP-PVGLETWDTSK-SIREPPQAAHPSRTYG 1929

Human  1977 IFSTASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLIS 2041
            ||||||||::|||||||:.|||||||::...||:.|.|..:.||......:.||:.:.:.:.::|
Mouse  1930 IFSTASGKAIQVSDASLEKARQVFSEMDGDAKQLSSMVSLEGNEKPHHSVKRENSVVHSTQGVLS 1994

Human  2042 -QKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQNVSKI 2105
             .|....| ||||.|||||||.||.|::.||:||||||:|||||||||||:|.:||.. ::||||
Mouse  1995 LPKPLPGN-VNSSVFSGFSTAGGKLVTVSESALHKVKGMLEEFDLIRTEHTLQHSPIP-EDVSKI 2057

Human  2106 LPR--VDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQDKQ-QLVL 2167
            ||:  .:.|.||:.|||:::||.:.:..|.:|.. |.|||.|..||:||..|||.::::. ||||
Mouse  2058 LPQPCAEIRTPEYPVNSKLQKTYNDKSSLPSNYK-ESGSSGNTQSIEVSLQLSQMERNQDTQLVL 2121

Human  2168 GTKVSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSENYFETEAVEIAK 2232
            ||||| ....::|||||..|:|:|::..:.:||||||||||  |...|||:|||||||||||.||
Mouse  2122 GTKVS-HSKANLLGKEQTLPQNIKVKTDEMKTFSDVPVKTN--VGEYYSKESENYFETEAVESAK 2183

Human  2233 AFMEDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILVGEPSIKRNLLNEFDRII 2297
            |||||||||||: .:||..||||||:||  .|.|||..||.|..:..||:|.|||:|||||||||
Mouse  2184 AFMEDDELTDSE-QTHAKCSLFTCPQNE--TLFNSRTRKRGGVTVDAVGQPPIKRSLLNEFDRII 2245

Human  2298 ENQEKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKERQEIQNPNFTAPGQEFLSKSHL 2362
            |::.|||..||||||||:|||.||.||:||||:||.||.::||||..|.|:.|:|.||.|||.|.
Mouse  2246 ESKGKSLTPSKSTPDGTVKDRSLFTHHMSLEPVTCGPFCSSKERQGAQRPHLTSPAQELLSKGHP 2310

Human  2363 YEHLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTGRPTKVFVPPFKTKSHFHRVEQC-VRNI 2426
            :.|..||||.|:..||..|.:.|||||.|:.||   :|:.|||||||||.||.||..|.. .:|:
Mouse  2311 WRHSALEKSPSSPIVSILPAHDVSATRTERTRH---SGKSTKVFVPPFKMKSQFHGDEHFNSKNV 2372

Human  2427 NLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKNNSNQAVAVTFTKCEEEPLDLITSLQNARDIQ 2491
            |||...|| :.||...|.     ||:.:.||||                   ||::|||:|||:|
Mouse  2373 NLEGKNQK-STDGDREDG-----NDSHVRQFNK-------------------DLMSSLQSARDLQ 2412

Human  2492 DMRIKKKQRQRVFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKN 2556
            |||||.|:|:.:..|||||||.|:||||||||:||||.:.|||||.||||.|||||.||.:||||
Mouse  2413 DMRIKNKERRHLRLQPGSLYLTKSSTLPRISLQAAVGDRAPSACSPKQLYIYGVSKECINVNSKN 2477

Human  2557 AESFQFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVY 2621
            ||.|||..:|:||||.|..|||.|||||||||||||||||||||||||||||||||||||.|||.
Mouse  2478 AEYFQFDIQDHFGKEDLCAGKGFQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISSIWVA 2542

Human  2622 NHYRWIIWKLAAMECAFPKEFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTL 2686
            ||||||:|||||||.|||||||||||:|||||||||||||.|||.|||||:|||:||||||||||
Mouse  2543 NHYRWIVWKLAAMEFAFPKEFANRCLNPERVLLQLKYRYDVEIDNSRRSALKKILERDDTAAKTL 2607

Human  2687 VLCVSDIISLSANISETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKI 2751
            |||:|||||.|..:||||..|||..|..||..||||||||||:|||||||:|::|:|:|||||||
Mouse  2608 VLCISDIISPSTKVSETSGGKTSGEDANKVDTIELTDGWYAVRAQLDPPLMALVKSGKLTVGQKI 2672

Human  2752 ILHGAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVG 2816
            |..|||||||||||.|||||:||.|||||||||||||:::||||.||||||||||||||||||||
Mouse  2673 ITQGAELVGSPDACAPLEAPDSLRLKISANSTRPARWHSRLGFFRDPRPFPLPLSSLFSDGGNVG 2737

Human  2817 CVDVIIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENTT 2881
            |||:|:||.||:||:|||.|||||||:||||||||.::.|||||:|||||||:..||::|||:||
Mouse  2738 CVDIIVQRVYPLQWVEKTVSGLYIFRSEREEEKEALRFAEAQQKKLEALFTKVHTEFKDHEEDTT 2802

Human  2882 KPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKKQAQIQL 2946
            :..:.||.||||||.|||||||||.||:.|:||.:||..|||||||||||:||||||||||:||.
Mouse  2803 QRCVLSRTLTRQQVHALQDGAELYAAVQYASDPDHLEACFSEEQLRALNNYRQMLNDKKQARIQS 2867

Human  2947 EIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLLTEGKRYRIYHL 3011
            |.|||:|||| ||:|||||||||||||:.||.|||| |.:||||||||||.||||||||||||||
Mouse  2868 EFRKALESAE-KEEGLSRDVTTVWKLRVTSYKKKEK-SALLSIWRPSSDLSSLLTEGKRYRIYHL 2930

Human  3012 ATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKFLDPDFQPSCSEVDLIG 3076
            |.||||||.||.:|||.|||:|||||||||.|.|.|:|||||.||||:..||.|||.|||||::|
Mouse  2931 AVSKSKSKFERPSIQLTATKRTQYQQLPVSSETLLQVYQPRESLHFSRLSDPAFQPPCSEVDVVG 2995

Human  3077 FVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHMLIAASNLQWRPESKSGLLTLFAG 3141
            .||||||..||||.|||||||.|||.:||.|||||| |||.:||||||||.:|||.||:.|||||
Mouse  2996 VVVSVVKPIGLAPLVYLSDECLNLLVVKFGIDLNED-IKPRVLIAASNLQCQPESTSGVPTLFAG 3059

Human  3142 DFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKLMHILHANDPKWSTPTKDCTSGPYTAQ 3206
            .||:|||||||.:|||..|.:|:.:||||....|||.||:|:|..:.||||||.||.|..|:.|.
Mouse  3060 HFSIFSASPKEAYFQEKVNNLKHAIENIDTFYKEAEKKLIHVLEGDSPKWSTPNKDPTREPHAAS 3124

Human  3207 I-----IPGTGNKLLMSSPNCEIYYQSPLSLCMAKRKSVSTPVSAQMTSKSCKGEKEIDDQKNCK 3266
            .     :.|:|.:.|..||..:..||||||.|..|.||:....||||.:||..||.||||.|.|:
Mouse  3125 TCCASDLLGSGGQFLRISPTGQQSYQSPLSHCTLKGKSMPLAHSAQMAAKSWSGENEIDDPKTCR 3189

Human  3267 KRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQPPRSCGTKYETPIKKKELNSPQMTPFKKFNEI 3331
            ||||||||||||||.|||||||||||||||||||||||||||.|||||:..:..:.|||:|.:.:
Mouse  3190 KRRALDFLSRLPLPSPVSPICTFVSPAAQKAFQPPRSCGTKYATPIKKEPSSPRRRTPFQKTSGV 3254

Human  3332 SLLESNSIADEELALINTQALLSGSTGEKQFISVSESTR-----------TAPTSSEDYLR 3381
            ||.:.:|:|||||||::||||...|.|..:.....:|||           ..|.|.::.||
Mouse  3255 SLPDCDSVADEELALLSTQALTPDSVGGNEQAFPGDSTRNPQPAQRPDQQVGPRSRKESLR 3315

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BRCA2NP_000050.3 Interaction with PALB2 1..40 30/38 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 37..68 24/30 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 358..381 11/22 (50%)
Interaction with NPM1. /evidence=ECO:0000269|PubMed:21084279 639..1000 167/366 (46%)
BRCA2 1 1002..1036 31/33 (94%)
Interaction with RAD51. /evidence=ECO:0000250|UniProtKB:P97929 1003..2082 559/1110 (50%)
BRCA2 1005..1033 CDD:459881 26/27 (96%)
BRCA2 1216..1243 CDD:459881 19/26 (73%)
Interaction with POLH. /evidence=ECO:0000269|PubMed:24485656 1338..1781 212/464 (46%)
Required for stimulation of POLH DNA polymerization activity 1410..1595 94/187 (50%)
BRCA2 1424..1452 CDD:459881 18/27 (67%)
BRCA2 1522..1548 CDD:459881 22/25 (88%)
BRCA2 1667..1695 CDD:459881 16/27 (59%)
BRCA2 1974..2002 CDD:459881 22/27 (81%)
BRCA2 8 2051..2085 25/33 (76%)
BRCA2 2055..2082 CDD:459881 19/26 (73%)
Interaction with HSF2BP. /evidence=ECO:0000269|PubMed:31242413 2270..2337 45/66 (68%)
Interaction with FANCD2 2350..2545 101/195 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2430..2450 5/19 (26%)
Interaction with SEM1. /evidence=ECO:0000269|PubMed:10373512, ECO:0000269|PubMed:16205630 2481..2832 278/350 (79%)
BRCA-2_helical 2481..2667 CDD:462700 148/185 (80%)
BRCA-2_OB1 2670..2796 CDD:462678 96/125 (77%)
Nuclear export signal, masked by interaction with SEM1. /evidence=ECO:0000269|PubMed:24013206 2682..2698 13/15 (87%)
BRCA2DBD_OB2 2804..3054 CDD:239940 192/249 (77%)
BRCA-2_OB3 3052..3186 CDD:462679 91/133 (68%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3393..3418
Brca2NP_033895.2 Interaction with PALB2. /evidence=ECO:0000250 1..40 30/38 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 37..69 25/31 (81%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..241 18/33 (55%)
Interaction with NPM1. /evidence=ECO:0000250 628..979 167/366 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 628..650 12/23 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 934..965 12/32 (38%)
BRCA2 1 981..1015 31/33 (94%)
Interaction with RAD51. /evidence=ECO:0000269|PubMed:30760716 982..2035 559/1110 (50%)
BRCA2 984..1012 CDD:459881 26/27 (96%)
BRCA2 1195..1223 CDD:459881 19/27 (70%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1296..1340 24/47 (51%)
BRCA2 1397..1423 CDD:459881 18/28 (64%)
BRCA2 1496..1522 CDD:459881 22/25 (88%)
BRCA2 1626..1654 CDD:459881 16/27 (59%)
BRCA2 1927..1955 CDD:459881 22/27 (81%)
BRCA2 7 2004..2038 25/33 (76%)
BRCA2 2008..2035 CDD:459881 19/26 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2073..2099 10/26 (38%)
Interaction with HSF2BP. /evidence=ECO:0000269|PubMed:30760716, ECO:0000269|PubMed:32345962 2219..2285 45/65 (69%)
Interaction with FANCD2. /evidence=ECO:0000250 2298..2466 101/195 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2361..2393 14/37 (38%)
Interaction with SEM1. /evidence=ECO:0000250|UniProtKB:P51587 2402..2753 278/350 (79%)
BRCA-2_helical 2402..2588 CDD:462700 148/185 (80%)
BRCA-2_OB1 2591..2717 CDD:462678 96/125 (77%)
Nuclear export signal, masked by interaction with SEM1. /evidence=ECO:0000250|UniProtKB:P51587 2603..2619 13/15 (87%)
BRCA2DBD_OB2 2725..2973 CDD:239940 192/249 (77%)
BRCA-2_OB3 2971..3102 CDD:462679 90/131 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3221..3257 21/35 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3273..3329 12/43 (28%)
Blue background indicates that the domain is not in the aligned region.

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