DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SSB and La

DIOPT Version :9

Sequence 1:	NP_001281074.1	Gene:	SSB / 6741	HGNCID:	11316	Length:	408	Species:	Homo sapiens
Sequence 2:	NP_477014.1	Gene:	La / 35305	FlyBaseID:	FBgn0011638	Length:	390	Species:	Drosophila melanogaster

Alignment Length:	385	Identity:	138/385 - (35%)
Similarity:	208/385 - (54%)	Gaps:	60/385 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     2 AENGDNEK---MAALEA---------KICHQIEYYFGDFNLPRDKFLKEQI-KLDEGWVPLEIMI 53
            |:|||.:|   .||.||         .|..|:||||||.||.|||||:||| |.::|||||.:::
  Fly    27 AKNGDAKKDPAPAAEEAAGGFTKQERAIIRQVEYYFGDANLNRDKFLREQIGKNEDGWVPLSVLV 91

Human    54 KFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGF 118
            .|.||..|:||.:.||.||:||:..|:||||||..:||.|.:|:||..:|.:.:::.|:.|.|||
  Fly    92 TFKRLASLSTDLSEIVAALNKSEEGLVEISEDKLSLRRHPERPIPEHNEERRKEIQERTAYAKGF 156

Human   119 PTDATLDDIKEWLEDKGQVLNIQMRRTLHK-----AFKGSIFVVFDSIESAKKFVETPGQKYKET 178
            |.|:.:.::.::..:..:|:|:.||:...|     .||||||:.|::.:.||.|:|.....|||.
  Fly   157 PLDSQISELLDFAANYDKVVNLTMRKHYDKPTKSYKFKGSIFLTFETKDQAKAFLEQEKIVYKER 221

Human   179 DLLILFKDDY-------FAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKF 236
            :||..::.||       :|:|||:|| ||.|||      .|...:|.::|           ::.|
  Fly   222 ELLRKWQVDYLKEKQEEYAQKNEKRK-NKKEAK------PEPAFELPKNA-----------IVVF 268

Human   237 SGDLDDQTCREDLHILFS--NHGEIKWIDFVRGAKEGIILFKEK-------AKEALGKAKDANNG 292
            .| ..:.:.||::...|.  ...|:.:|:|.:|..:|.:...|.       ||...||.|..:..
  Fly   269 EG-APETSSREEIREAFEKIKDFEVAYIEFAKGETKGSVRLTEADAAEKYIAKVEEGKLKFKDEV 332

Human   293 NLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGK 352
            :|.||.       ...|.|||.:.|.||..::..:..::||:||..|..|....:.|.||
  Fly   333 SLSLRK-------ATEEEEKEFIDKAIEFMKKRRDFTRNKGKRFNRKRHGGNDHKHGGGK 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SSB	NP_001281074.1	LARP_3	10..91	CDD:153397	47/90 (52%)
		RRM1_La	112..183	CDD:240737	27/75 (36%)
		RRM_3	231..334	CDD:370115	27/111 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..408		9/24 (38%)
La	NP_477014.1	LARP_3	47..129	CDD:153397	43/81 (53%)
		RRM1_La	150..226	CDD:240737	27/75 (36%)
		RRM_SF	263..338	CDD:302621	19/86 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155495
Domainoid	1	1.000	71	1.000	Domainoid score	I9481
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2366
Inparanoid	1	1.050	197	1.000	Inparanoid score	I3812
Isobase	1	0.950	-	0	Normalized mean entropy	S2962
OMA	1	1.010	-	-		QHG54025
OrthoDB	1	1.010	-	-		D400042at33208
OrthoFinder	1	1.000	-	-		FOG0002882
OrthoInspector	1	1.000	-	-		oto89731
orthoMCL	1	0.900	-	-		OOG6_102594
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R649
SonicParanoid	1	1.000	-	-		X1665
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.890