Protein Alignment SRY and Sox15

DIOPT Version :9

• Sequence 1: NP_003131.1
• Gene: SRY / 6736
• HGNCID: 11311
• Length: 204
• Species: Homo sapiens
• Sequence 2: NP_523739.2
• Gene: Sox15 / 36575
• FlyBaseID: FBgn0005613
• Length: 784
• Species: Drosophila melanogaster
• Alignment Length: 201
• Identity: 60/201 - (29%)
• Similarity: 96/201 - (47%)
• Gaps: 38/201 - (18%)

Human    35 LCTESC-----------NSKYQCETGENSKGNVQDRVKRPMNAFIVWSRDQRRKMALENPRMRNS 88
            ||..:|           :.||: ..|..||...:.|::||||||:||::.:|:|:|.|||.:.|:
  Fly   180 LCAPNCGYLERHKPLPADLKYR-PGGTQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNA 243

Human    89 EISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAK-----MLP--------- 139
            ::||.||.:|:.||..::.|:.:||::|:.:|..::|||||||||:.:     |.|
  Fly   244 DLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRKQSKLRAMQPGGKEQSESS 308

Human   140 --------KNCSLLPADPASVLCSEVQLDNRLYRDDCTKATHSRMEHQLGHL--PPINAASSPQQ 194
                    |:...|...|.:...|.......  ...|.....:..:...|.|  .|:....||..
  Fly   309 PNPGTGGSKSNPKLATPPLATASSSYTTPTD--ESTCNSTNQNHGQSTPGGLYEQPLKPTYSPSS 371

Human   195 RDRYSH 200
            .|.||:
  Fly   372 VDCYSN 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRY	NP_003131.1	Sufficient for interaction with KPNB1. /evidence=ECO:0000269|PubMed:15297880	59..136		37/76 (49%)
		SOX-TCF_HMG-box	59..130	CDD:238684	32/70 (46%)
		Required for nuclear localization. /evidence=ECO:0000269|PubMed:12764225, ECO:0000269|PubMed:15746192	61..77		9/15 (60%)
		Sufficient for interaction with EP300. /evidence=ECO:0000269|PubMed:15297880	107..139		15/36 (42%)
		Required for nuclear localization. /evidence=ECO:0000269|PubMed:15297880	130..136		4/5 (80%)
		Necessary for interaction with ZNF208 isoform KRAB-O. /evidence=ECO:0000269|PubMed:15469996	138..155		4/33 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	175..204		8/28 (29%)
		Necessary for interaction with SLC9A3R2. /evidence=ECO:0000269|PubMed:9054412	198..204		2/3 (67%)
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	32/70 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148469
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940