Protein Alignment SRP54 and Srp54k

DIOPT Version :10

• Sequence 1: NP_003127.1
• Gene: SRP54 / 6729
• HGNCID: 11301
• Length: 504
• Species: Homo sapiens
• Sequence 2: NP_523931.1
• Gene: Srp54k / 38593
• FlyBaseID: FBgn0010747
• Length: 508
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 387/505 - (76%)
• Similarity: 453/505 - (89%)
• Gaps: 4/505 - (0%)

Human     1 MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLEEM 65
            |||||||||||:||.|||.||:||||.||:||||:|.|||||||||:|||||||||::.||.:||
  Fly     1 MVLADLGRKITTALHSLSKATVINEEALNSMLKEICAALLEADVNIRLVKQLRENVRAVIDFDEM 65

Human    66 ASGLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGW 130
            |.|||||:|||.|||||||||||||||.:.|.|||.||:||||||||||||||:||||:||::.|
  Fly    66 AGGLNKRRMIQSAVFKELVKLVDPGVKPYQPIKGKANVVMFVGLQGSGKTTTCTKLAYHYQKRNW 130

Human   131 KTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRH 195
            |:||:|||||||||:||:|||||||||||||||||:|||:||.:||:.||.|.||:|||||||||
  Fly   131 KSCLVCADTFRAGAYDQVKQNATKARIPFYGSYTEIDPVVIAQDGVDMFKREGFEMIIVDTSGRH 195

Human   196 KQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGAL 260
            |||:|||||||.|:||:.||||::||||:|||||||||||||||||:.|||:|||||||||||||
  Fly   196 KQEESLFEEMLAVSNAVSPDNIIFVMDATIGQACEAQAKAFKDKVDIGSVIITKLDGHAKGGGAL 260

Human   261 SAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLIDKVNELKLDDNEALIEKLKHG 325
            ||||||:||||||||||||||.|||||:||:||||||||||||||||||||||.|:.|:||:|||
  Fly   261 SAVAATQSPIIFIGTGEHIDDLEPFKTKPFVSKLLGMGDIEGLIDKVNELKLDGNDELLEKIKHG 325

Human   326 QFTLRDMYEQFQNIMKMGPFSQILGMIPGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDST 390
            .||:||||||||||||||||||.:.|||||..|||:||.|||||||:|::||:||||:|.|||:.
  Fly   326 HFTIRDMYEQFQNIMKMGPFSQFMNMIPGFSQDFMTKGGEQESMARVKRMMTMMDSMSDNELDNR 390

Human   391 DGAKVFSKQPGRIQRVARGSGVSTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVSQSQM 455
            ||||:|||||.|..|||:|:||..|:|:||:..||||:.:||||||:|||||.|||:|||:.:||
  Fly   391 DGAKLFSKQPNRCVRVAQGAGVMEREVKELIAHYTKFSAVVKKMGGVKGLFKQGDMTKNVNPTQM 455

Human   456 AKLNQQMAKMMDPRVLHHMGGMAGLQSMMRQFQQGAAGNMKG----MMGF 501
            ||||||:|||:|||:|..|||:.|:|:||||.||||||.:.|    |.||
  Fly   456 AKLNQQIAKMIDPRMLQQMGGVGGIQNMMRQLQQGAAGGLGGLGNLMSGF 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRP54	NP_003127.1	NG domain. /evidence=ECO:0000303|PubMed:34020957	1..295		237/293 (81%)
		SRP54_euk	2..430	CDD:273615	335/427 (78%)
		M-domain. /evidence=ECO:0000303|PubMed:34020957	296..504		148/210 (70%)
Srp54k	NP_523931.1	SRP54_euk	2..428	CDD:273615	334/425 (79%)