Protein Alignment SRMS and Src64B

DIOPT Version :9

• Sequence 1: NP_543013.1
• Gene: SRMS / 6725
• HGNCID: 11298
• Length: 488
• Species: Homo sapiens
• Sequence 2: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Alignment Length: 479
• Identity: 196/479 - (40%)
• Similarity: 276/479 - (57%)
• Gaps: 36/479 - (7%)

Human    25 EPDH------GTPGSLD---PNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCA 80
            :|:|      |..|.:|   |.|.|.    ..|.....::.:||||:.:|...:||..:|||:..
  Fly    64 DPNHRGPLKIGGKGGVDIIRPRTTPT----GVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEV 124

Human    81 LE--EGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGA 143
            ::  |...:......:.|  .||:|:..||:  ..:::.:.|:|..|.|.:|.:|||:..|..|.
  Fly   125 IDDTESDWWRVVNLTTRQ--EGLIPLNFVAE--ERSVNSEDWFFENVLRKEADKLLLAEENPRGT 185

Human   144 FLIRPSESSLGGYSLSVR-----AQAKVCHYRVSMAADGSLYLQKGRLFPGLEEL-LTYYKANWK 202
            ||:||||.:..||||||:     ....|.|||:....:|..|:...:.||.|:.| :.|.|.|..
  Fly   186 FLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENAL 250

Human   203 LIQNPLLQPCMPQKAPR--------QDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKV 259
            .:.:.|.:|| |:..|:        :|.:|.|.||..|.||||.|.||||:.|.|..|:.||:|.
  Fly   251 GLCHILSRPC-PKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKT 314

Human   260 IKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRL 324
            ::...|......:|...:|..||.||:.|:||||..||:|||.|.|.||:|..||...:||.|..
  Fly   315 LREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHF 379

Human   325 PPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIP 389
            ..|:..|.|||.||.|||.::::||||||||||:.:....|:.||||||::.||.|.|...|:.|
  Fly   380 EDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFP 444

Human   390 VKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPA--ACP 452
            ||||||||..|..||.||||||:|:||.|:|||||.||.||.:.|.::.|.||:|:|:|.  ..|
  Fly   445 VKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFP 509

Human   453 AEVYVLMLECWRSSPEERPSFATL 476
            ..:|.|:|:||.:.||:||:|..|
  Fly   510 DNIYQLLLQCWDAVPEKRPTFEFL 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRMS	NP_543013.1	SH3_Srms	55..109	CDD:212780	16/55 (29%)
		SH2	119..197	CDD:301589	32/83 (39%)
		PTKc_Srm_Brk	223..483	CDD:133248	129/256 (50%)
		STYKc	232..480	CDD:214568	125/247 (51%)
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	15/52 (29%)
		SH2_Src_family	158..259	CDD:199827	36/100 (36%)
		STYKc	285..537	CDD:214568	125/249 (50%)
		PTKc_Src_like	289..538	CDD:270630	124/245 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820