DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRMS and src-2

DIOPT Version :9

Sequence 1:	NP_543013.1	Gene:	SRMS / 6725	HGNCID:	11298	Length:	488	Species:	Homo sapiens
Sequence 2:	NP_493502.1	Gene:	src-2 / 173296	WormBaseID:	WBGene00005078	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	492	Identity:	205/492 - (41%)
Similarity:	287/492 - (58%)	Gaps:	51/492 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    32 GSLDP---NTDPVPT--------LPAEPCSPFPQL-----------------------FLALYDF 62
            |..||   .|.||.|        ||:.|  ..|.:                       |:||:.:
Worm     6 GKEDPPPGATSPVHTSSTLGRESLPSHP--RIPSIGPIAASSSGNTIDKNQNISQSANFVALFQY 68

Human    63 TARCGGELSVRRGDRLCALEE-GGGYIFAR-RLSGQPSAGLVPITHVAKASPETLSDQPWYFSGV 125
            .||...:||.::.|.|..|.: .|.:.||| :.:|:  .|.:|..:||:  .:::..|||||..:
Worm    69 DARTDDDLSFKKDDILEILNDTQGDWWFARHKATGR--TGYIPSNYVAR--EKSIESQPWYFGKM 129

Human   126 SRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGL 190
            .|..|::.||...||.||||:|.|||.....|||||....|.|||:.....|..::.:.|.|..|
Worm   130 RRIDAEKCLLHTLNEHGAFLVRDSESRQHDLSLSVRENDSVKHYRIRQLDHGGYFIARRRPFATL 194

Human   191 EELLTYYKANWKLIQNPLLQPCMPQKAPR------QDVWERPHSEFALGRKLGEGYFGEVWEGLW 249
            .:|:.:|:.....:...|..||...:||:      .|.||.......|.|::|.|.|||||||.|
Worm   195 HDLIAHYQREADGLCVNLGAPCAKSEAPQTTTFTYDDQWEVDRRSVRLIRQIGAGQFGEVWEGRW 259

Human   250 LGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFL 314
            ..::|||:|.:|:.....||...|.|.:|.|||.:|:.|:|||:..||:.||||||:: ||..||
Worm   260 NVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQE-NLLTFL 323

Human   315 GTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLAR-LLKDD 378
             ...||..::|.|:..:.|||.||:||||...:||||||||:|:::.|:.|:||||||| |:|::
Worm   324 -QRRGRQCQMPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMKEN 387

Human   379 IYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGY 443
            .|...:.::.|:||||||||||..|:.||||||||:||.|:.|:|:.||.||||.|.|||:..||
Worm   388 EYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPYPGMTNAEVLQQVDAGY 452

Human   444 RLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
            |:|.||.||..:|.:|.:||||.|::||:|.||:.||
Worm   453 RMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRMS	NP_543013.1	SH3_Srms	55..109	CDD:212780	18/78 (23%)
		SH2	119..197	CDD:301589	32/77 (42%)
		PTKc_Srm_Brk	223..483	CDD:133248	135/259 (52%)
		STYKc	232..480	CDD:214568	131/248 (53%)
src-2	NP_493502.1	SH3_Src_like	61..112	CDD:212779	17/52 (33%)
		SH2_Src_Src42	120..215	CDD:198233	35/94 (37%)
		PTKc_Frk_like	231..496	CDD:270653	136/261 (52%)
		Pkinase_Tyr	240..489	CDD:285015	131/250 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820