Protein Alignment SRMS and src-1

DIOPT Version :9

• Sequence 1: NP_543013.1
• Gene: SRMS / 6725
• HGNCID: 11298
• Length: 488
• Species: Homo sapiens
• Sequence 2: NP_001364829.1
• Gene: src-1 / 171722
• WormBaseID: WBGene00005077
• Length: 537
• Species: Caenorhabditis elegans
• Alignment Length: 446
• Identity: 181/446 - (40%)
• Similarity: 260/446 - (58%)
• Gaps: 29/446 - (6%)

Human    54 QLFLALYDFTARCGGELSVRRGDRLCALEEGG---GYIFARRLSGQPSAGLVPITHVAKASPETL 115
            :..:|||.:.:|..|:||.::||.:..|:...   .|:..:| :||  .|.||...|||  .:|:
 Worm    78 ETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQR-TGQ--TGYVPRNFVAK--QQTI 137

Human   116 SDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQ------AKVCHYRVS-M 173
            ..:.||...:.|.:|::|:||.....|.||||..|:....::|::|..      ..|.||::. :
 Worm   138 ESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRL 202

Human   174 AADGSLYLQKGRLFPGLEELLTYYK------ANWKLIQNPLLQPCMPQKA-PRQDVWERPHSEFA 231
            ..|...::...|.|..|:||:.||.      ........|.|.|..|..: ..|..||.|.::..
 Worm   203 DHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLH 267

Human   232 LGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGE 296
            |.||||:|.|||||.|.|.|.:.||||.:|...|......:|.|.:|...|..|::|:|||:..|
 Worm   268 LKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTREE 332

Human   297 PVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDG 361
            |.||:||.|..|:|..:|.| :|..|.:..|:..|.|:|.||.||||:::||||||||||||.|.
 Worm   333 PFYIITEYMINGSLLQYLRT-DGSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDK 396

Human   362 LA----CKVADFGLAR-LLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFT 421
            ::    .||||||||| |:::|||...:.:|.|:||||||||....|:.||||||:|:||:|:.|
 Worm   397 ISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMT 461

Human   422 YGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVY-VLMLECWRSSPEERPSFATL 476
            .||.||.||.|.|.::|:..|||:|.|..||.::| .::|:||..:|:.||:|.||
 Worm   462 KGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTL 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRMS	NP_543013.1	SH3_Srms	55..109	CDD:212780	18/56 (32%)
		SH2	119..197	CDD:301589	24/84 (29%)
		PTKc_Srm_Brk	223..483	CDD:133248	129/260 (50%)
		STYKc	232..480	CDD:214568	126/251 (50%)
src-1	NP_001364829.1	SH3_Src_like	79..130	CDD:212779	17/53 (32%)
		SH2_Src_family	138..240	CDD:199827	26/101 (26%)
		PTKc_Src_like	270..522	CDD:270630	125/249 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820