DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRMS and ptk6

DIOPT Version :9

Sequence 1:	NP_543013.1	Gene:	SRMS / 6725	HGNCID:	11298	Length:	488	Species:	Homo sapiens
Sequence 2:	XP_002942429.3	Gene:	ptk6 / 100490792	XenbaseID:	XB-GENE-22069031	Length:	563	Species:	Xenopus tropicalis

Alignment Length:	469	Identity:	194/469 - (41%)
Similarity:	262/469 - (55%)	Gaps:	38/469 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    31 PGS-LDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRL- 93
            ||: ||.|.         ..|..|:.|::|:||.|....|||.:.||....|:..|.:...::|
Frog    87 PGNWLDGNA---------KMSHRPKRFVSLWDFKAEAPEELSFKVGDVFEVLDRSGDWWHVQKLK 142

Human    94 ---SGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGG 155
               .|:|..|.||...:|:..  |:.:|.|:|...|||:|..||:...|..|:||||.|:.....
Frog   143 GDGKGKPEVGYVPYNFLAEEG--TVEEQEWFFGEKSRTEAVNLLMDEGNTNGSFLIRASDKHGIL 205

Human   156 YSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELL-TYYKANWKLIQNP------LLQPCM 213
            |.||||.|....|:::....:|..:|.....||.|::|: ||.|       .|      |.:||:
Frog   206 YVLSVRHQDSTRHFKIMRNPEGQFHLNNMTFFPDLKQLVETYCK-------KPICPGLTLTKPCV 263

Human   214 PQKAPRQDV-------WERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLA 271
            ..:....|:       ||||..||.|.::||.|.||:|.||||.|.|.||:|.||..........
Frog   264 KNEPVVSDLSPVPLDEWERPREEFTLVKRLGMGNFGQVHEGLWKGKLKVAVKTIKRDATSQDLFV 328

Human   272 KEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAE 336
            ||...||.|.|:.|:.|:||||.|:|.||||||:.:|:|..:|...|...|.:...|..|.||||
Frog   329 KETAFLKTLHHKNLLSLYAVCSVGDPYYIVTELVPRGDLLNYLRDLEKDELDVEGQLDIATQVAE 393

Human   337 GMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYR 401
            ||.|||.|..:||||||||||:.....||:||||:||::.|..| .|:|.:||.|||||||..|.
Frog   394 GMRYLESQNCIHRDLAARNVLMGRNNICKIADFGMARVILDSYY-VSASKEIPFKWTAPEAVEYG 457

Human   402 VFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSS 466
            .::.||||||||:||:|:.:.|..||..::|:|.|:.:.||.|:..|.:|...||.:||.||..:
Frog   458 RYTVKSDVWSFGILLYEIMSLGMQPYPALSNYEVLEFLNRGQRMKAPPSCSTRVYNIMLTCWAWN 522

Human   467 PEERPSFATLREKL 480
            |.|||||..||..|
Frog   523 PNERPSFDDLRTML 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRMS	NP_543013.1	SH3_Srms	55..109	CDD:212780	18/57 (32%)
		SH2	119..197	CDD:301589	29/78 (37%)
		PTKc_Srm_Brk	223..483	CDD:133248	130/258 (50%)
		STYKc	232..480	CDD:214568	123/247 (50%)
ptk6	XP_002942429.3	SH3	104..161	CDD:418401	18/56 (32%)
		SH2	168..252	CDD:214585	32/90 (36%)
		STYKc	288..536	CDD:214568	123/248 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920