DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRMS and srms

DIOPT Version :9

Sequence 1:	NP_543013.1	Gene:	SRMS / 6725	HGNCID:	11298	Length:	488	Species:	Homo sapiens
Sequence 2:	NP_001129722.2	Gene:	srms / 100192213	ZFINID:	ZDB-GENE-081022-95	Length:	492	Species:	Danio rerio

Alignment Length:	492	Identity:	222/492 - (45%)
Similarity:	318/492 - (64%)	Gaps:	18/492 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFP-----QLFLALY 60
            ||...|..:..|...||.|||. ..|:...|       |.:.|:..:...|.|     ||:.||:
Zfish     1 METCCRCCMPCLKRLWDSIWPE-NYPNLHRP-------DDIRTVSGDIRVPAPKKKPAQLYAALF 57

Human    61 DFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGV 125
            ||.||...||||:.||:|..:|:.|.|:||::|:|...:||:|..:||....| .::..||:..:
Zfish    58 DFVARSEEELSVKEGDKLSVIEKRGDYVFAKKLTGSLESGLIPANYVALLKDE-FANYKWYYGNI 121

Human   126 SRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGL 190
            :|.:|::||||..|:.|:||:|.|||....|::|.|::..|.|:|:..:..|:.::.:...|..|
Zfish   122 NRQKAEKLLLSSENKTGSFLVRISESHSDEYTISARSENSVFHFRIHRSPIGAYFVSEKISFGTL 186

Human   191 EELLTYYKANWKLIQNPLLQPCMPQKAPRQDV--WERPHSEFALGRKLGEGYFGEVWEGLW-LGS 252
            :||:.||:.|.:.:...:.|||: |:....|:  ||||..||.|.:|||||:||||||.:| ...
Zfish   187 DELIRYYQQNSRSLGCHIDQPCV-QRRELFDMEPWERPREEFMLVKKLGEGHFGEVWEAIWKTQK 250

Human   253 LPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTP 317
            ..||||::|..:.||.:..||:..||.|.|.:||.|.|:||.|||||||||||.||:|:::|.:.
Zfish   251 KKVAIKMLKQEDTKLDEFVKEVHALKNLHHPKLIELLALCSRGEPVYIVTELMAKGSLKSYLSSA 315

Human   318 EGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSP 382
            ||:.|....|:..|.|:||||:|||::.:|||||||||:||.:.|.||||||||||::||.:::.
Zfish   316 EGQLLTSAHLIYMAAQIAEGMAYLEDRHIVHRDLAARNILVGNDLVCKVADFGLARIIKDSVFTA 380

Human   383 SSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPR 447
            |.::||||:|||||||.|:.||.|||||||||||:|:.:.|:.||:|.||.|.::.:..||||..
Zfish   381 SKTTKIPVRWTAPEAALYQRFSVKSDVWSFGVLLYEMMSRGKMPYDGKTNKEVMEALSSGYRLAC 445

Human   448 PAACPAEVYVLMLECWRSSPEERPSFATLREKLHAIH 484
            |..||..:|.:|||||.:...:||||..|..:|..|:
Zfish   446 PNHCPPNIYRIMLECWNNEASKRPSFHALHSQLDNIY 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRMS	NP_543013.1	SH3_Srms	55..109	CDD:212780	25/53 (47%)
		SH2	119..197	CDD:301589	27/77 (35%)
		PTKc_Srm_Brk	223..483	CDD:133248	143/260 (55%)
		STYKc	232..480	CDD:214568	136/248 (55%)
srms	NP_001129722.2	SH3	52..106	CDD:302595	25/53 (47%)
		SH2	114..197	CDD:214585	29/82 (35%)
		PKc_like	220..481	CDD:304357	143/260 (55%)
		STYKc	229..478	CDD:214568	136/248 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194331552
Domainoid	1	1.000	288	1.000	Domainoid score	I7911
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7957
Inparanoid	1	1.050	426	1.000	Inparanoid score	I7537
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG38691
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto46712
orthoMCL	1	0.900	-	-		OOG6_120350
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X10868
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.300