Protein Alignment SRF and bs

DIOPT Version :10

• Sequence 1: NP_003122.1
• Gene: SRF / 6722
• HGNCID: 11291
• Length: 508
• Species: Homo sapiens
• Sequence 2: NP_726438.1
• Gene: bs / 37890
• FlyBaseID: FBgn0004101
• Length: 449
• Species: Drosophila melanogaster
• Alignment Length: 494
• Identity: 183/494 - (37%)
• Similarity: 241/494 - (48%)
• Gaps: 101/494 - (20%)

Human     1 MLPTQAGAAAALGRG-SALGGSLNRTPT---GRPGGGGGTRGANGGRVPGNGAGLGPGRLEREAA 61
            |.||:..:...|... |::|.|| ..|.   |.|..|.| |..:||.:...| |:.|  ::|...
  Fly     1 MDPTRGDSRYNLNYSMSSIGLSL-ADPADMYGNPALGAG-RPPSGGLLQNMG-GVPP--MQRPNP 60

Human    62 AAAATTPAPTAGALYSGSEGDSESGEEEEL--------------GAERRGLKRSLSE-------M 105
            ||.| .|||....|:|......:..::::.              ..::||||||.|:       .
  Fly    61 AAGA-PPAPQCQTLHSPQHASQQQQQQQQQQQQHQQQQQQQQQHPQQQRGLKRSGSDCYEDHHRS 124

Human   106 EIGMVVGGPE--ASAA---ATGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRK 165
            ..|:.:.|.:  ||.|   :...|.|:....|....||||:||||||||:|||||||||||||||
  Fly   125 SGGLTLQGLDNVASGAVDDSVDNYNPLPNKKSPPANGKKTKGRVKIKMEYIDNKLRRYTTFSKRK 189

Human   166 TGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDP 230
            ||||||||||||||||||:|||||||||||||||||||||||||.||.||||||||||.|  |..
  Fly   190 TGIMKKAYELSTLTGTQVMLLVASETGHVYTFATRKLQPMITSEAGKQLIQTCLNSPDPP--SVG 252

Human   231 TTDQRMSATGFEETDLTYQVSESDS------------SGETKDTLKP---AFTVTNLPGTTSTIQ 280
            ..||||||||||||:|:|.:::.||            |.::.|...|   |...|.||.:.:.:.
  Fly   253 GGDQRMSATGFEETELSYNIADEDSKDDRSPTSSGNESDDSSDVEMPAEAAEVATKLPASKTEVS 317

Human   281 TAPSTS-TTMQVSSG-PSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSF 343
            ..|:.| :....||| .:.|..||....::..|.|..:...|    |..|..|.|.      .|.
  Fly   318 APPAASCSAATASSGHKTMPALNYQTDTNSGPSTSTAAGGGG----SADSKYVYSA------ASI 372

Human   344 TLMPGGAVAQQVPVQAIQVHQAPQQASPSRDSSTDLTQTSSSGTVTLP-----ATIMTSSVPTTV 403
            ..:|...:.|.:....:|||                .:...:..||:|     |.::.|:..|..
  Fly   373 ANIPQKMLRQLIQSGHLQVH----------------AEEDGNQYVTIPLSSTAANLIKSNKLTAS 421

Human   404 GGHMMYPSPHAVMYAPTSGLGDGSLTVLNAFSQAPSTMQ 442
            |               :...|.|:....:|.:..|.|::
  Fly   422 G---------------SGASGSGTPVKNDASADKPLTIK 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRF	NP_003122.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..97		28/113 (25%)
		MADS_SRF_like	142..223	CDD:238166	76/80 (95%)
		Involved in dimerization	168..222		50/53 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..240		13/20 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..385		2/22 (9%)
bs	NP_726438.1	MADS_SRF_like	166..247	CDD:238166	76/80 (95%)