Protein Alignment SREBF2 and TYE7

DIOPT Version :10

• Sequence 1: NP_004590.2
• Gene: SREBF2 / 6721
• HGNCID: 11290
• Length: 1141
• Species: Homo sapiens
• Sequence 2: NP_014989.3
• Gene: TYE7 / 854525
• SGDID: S000005871
• Length: 291
• Species: Saccharomyces cerevisiae
• Alignment Length: 279
• Identity: 57/279 - (20%)
• Similarity: 102/279 - (36%)
• Gaps: 90/279 - (32%)

Human   173 NAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQT----ANGTLQTLAPATVQTV-- 231
            :::|.|:.|:..:.|..:||...|:. .|.:.:...:..|..|    :|.:..:.:|....::
Yeast    50 SSSTWFEPLENIISSASSSSIGSPIE-DQFISSNNEESALFPTDQFFSNPSSYSHSPEVSSSIKR 113

Human   232 -------AAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVP 289
                   :....:...:.:.|.:|.||:                  |...|.|...|:.
Yeast   114 EEDDNALSLADFEPASLQLMPNMINTDN------------------NDDSTPLKNEIEL------ 154

Human   290 TLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELK 354
                :...|.|.:.....:::.|.|::....||           .||.||||||.:||.||..|:
Yeast   155 ----NDSFIKTNLDAKETKKRAPRKRLTPFQKQ-----------AHNKIEKRYRININTKIARLQ 204

Human   355 DLV-----------------------------------MGTDAKMHKSGVLRKAIDYIKYLQQVN 384
            .::                                   ..|..|::||.:|.||:|||.|||  |
Yeast   205 QIIPWVASEQTAFEVGDSVKKQDEDGAETAATTPLPSAAATSTKLNKSMILEKAVDYILYLQ--N 267

Human   385 HKLRQENMVLKLANQKNKL 403
            ::...|..|.:|.::.:.|
Yeast   268 NERLYEMEVQRLKSEIDTL 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBF2	NP_004590.2	Transcriptional activation (acidic). /evidence=ECO:0000269|PubMed:35120642	1..50
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..144
		Interaction with LMNA. /evidence=ECO:0000250|UniProtKB:Q3U1N2	237..491		45/202 (22%)
		bHLHzip_SREBP2	326..402	CDD:381492	30/110 (27%)
		Leucine-zipper	380..401		6/20 (30%)
TYE7	NP_014989.3	bHLHzip_SREBP_like	179..283	CDD:381401	32/116 (28%)