| Sequence 1: | NP_004590.2 | Gene: | SREBF2 / 6721 | HGNCID: | 11290 | Length: | 1141 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001262064.1 | Gene: | SREBP / 40155 | FlyBaseID: | FBgn0261283 | Length: | 1113 | Species: | Drosophila melanogaster |
| Alignment Length: | 1125 | Identity: | 350/1125 - (31%) |
|---|---|---|---|
| Similarity: | 525/1125 - (46%) | Gaps: | 132/1125 - (11%) |
- Green bases have known domain annotations that are detailed below.
|
Human 100 FSPSAASPQAPTLQVKVSPTSVPTTPRATPIL-QPRPQPQ------PQPQTQLQQQTVMITPTFS 157
Human 158 TTPQTRIIQQP-----LIYQN---AATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQ 214
Human 215 TA--------NGTLQTLAPAT------------VQTVAA---------PQVQQVPVLVQPQIIKT 250
Human 251 DSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPV------MMGQE 309
Human 310 KVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAI 374
Human 375 DYIKYLQQVNHKLRQENMVLK---LANQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLL---MSP 433
Human 434 PASDSGSQAGFSPYSID-SEPGSPL--------LDDAKVKDEPDSPPVAL-GMVDRSRILLCVLT 488
Human 489 FLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVF 553
Human 554 VKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFAAAAGNLQTCLAVLGRALPTSRLDLACS 618
Human 619 LSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAKTSARDAALAYHRLHQLHITGKLP 683
Human 684 AGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFL-ASYFLSRAQSLC 747
Human 748 G-PEHSAVPDSLRWLCHPLGQKFFMERSWSV---KSAAKESLYCAQRNPADPIAQVHQAFCKNLL 808
Human 809 ERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSPPLSRSSVLKSALGPDII 873
Human 874 CR-----WWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEV--TESPLVKAIFHACRAMHASL 931
Human 932 PGKADGQQSSFCH-----CERASGHLWSSLNVSGATSDPALNHVVQLLTCDLLLSLRTALWQKQA 991
Human 992 SASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEH 1056
Human 1057 SLRRRTTQSTKH-GEVDAWP-----GQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEK 1115
Human 1116 VGDRRSCNDCQQMIVKLGGG 1135 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| SREBF2 | NP_004590.2 | Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956 | 1..50 | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 48..144 | 12/50 (24%) | |||
| Interaction with LMNA. /evidence=ECO:0000250|UniProtKB:Q3U1N2 | 237..491 | 92/275 (33%) | |||
| HLH | 331..381 | CDD:278439 | 31/49 (63%) | ||
| Leucine-zipper | 380..401 | 8/23 (35%) | |||
| SREBP | NP_001262064.1 | HLH | 281..338 | CDD:238036 | 34/63 (54%) |
| OmpH | <289..>364 | CDD:281871 | 38/74 (51%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 329 | 1.000 | Domainoid score | I1159 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG2588 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 416 | 1.000 | Inparanoid score | I1828 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S6888 |
| OMA | 1 | 1.010 | - | - | QHG52391 | |
| OrthoDB | 1 | 1.010 | - | - | D167699at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001476 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41314 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_104643 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR46062 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R1708 |
| SonicParanoid | 1 | 1.000 | - | - | X2374 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 15 | 14.820 | |||||