| Sequence 1: | NP_004590.2 | Gene: | SREBF2 / 6721 | HGNCID: | 11290 | Length: | 1141 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001245436.1 | Gene: | Mitf / 3885647 | FlyBaseID: | FBgn0263112 | Length: | 837 | Species: | Drosophila melanogaster |
| Alignment Length: | 534 | Identity: | 108/534 - (20%) |
|---|---|---|---|
| Similarity: | 196/534 - (36%) | Gaps: | 171/534 - (32%) |
- Green bases have known domain annotations that are detailed below.
|
Human 56 GSGGSGSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSF--SPSAASPQAPTLQVKVSP 118
Human 119 TSVPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQP--LIYQNAATSFQVL 181
Human 182 QPQVQSLVTS-----------SQVQPVTIQQQV-------------QTVQAQRVLTQTANGTLQT 222
Human 223 LAPATVQTVAAPQVQQV-PVLVQPQ-----------------IIKTDSLVLTTLKTDG--SPVMA 267
Human 268 AVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMG---------QEKVPIKQVPGGVKQL 323
Human 324 EP---PKEGERRTTHNIIEKRYRSSINDKIIELKDLV-MGTDA--------KMHKSGVLRKAIDY 376
Human 377 IKYLQQVNHKLRQENM---VLKLANQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLL-------- 430
Human 431 ------------MSPPASDS-----------------GSQAGFSPYSIDS---------EPGSPL 457
Human 458 LDD-AKVKDEPDSP 470 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| SREBF2 | NP_004590.2 | Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956 | 1..50 | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 48..144 | 22/89 (25%) | |||
| Interaction with LMNA. /evidence=ECO:0000250|UniProtKB:Q3U1N2 | 237..491 | 65/325 (20%) | |||
| HLH | 331..381 | CDD:278439 | 22/58 (38%) | ||
| Leucine-zipper | 380..401 | 6/23 (26%) | |||
| Mitf | NP_001245436.1 | MITF_TFEB_C_3_N | <272..>311 | CDD:292573 | 16/65 (25%) |
| HLH | 505..570 | CDD:238036 | 23/64 (36%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R1708 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.940 | |||||