DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SREBF2 and Usf

DIOPT Version :9

Sequence 1:	NP_004590.2	Gene:	SREBF2 / 6721	HGNCID:	11290	Length:	1141	Species:	Homo sapiens
Sequence 2:	NP_572167.3	Gene:	Usf / 31384	FlyBaseID:	FBgn0029711	Length:	437	Species:	Drosophila melanogaster

Alignment Length:	454	Identity:	92/454 - (20%)
Similarity:	151/454 - (33%)	Gaps:	160/454 - (35%)

- Green bases have known domain annotations that are detailed below.

Human   110 PTLQVK----VSPTSVPTTPRATPILQPRPQPQPQPQTQLQQQT-----VMITPTFSTTPQTRII 165
            |.|.::    .|.|:..|:|.:..|....|...|...|.....|     .::..:|:...|:.|:
  Fly     7 PRLNMEFGSSTSNTNTSTSPSSVNISNANPTAGPGLMTITNHHTADLSEALVHSSFANGQQSLIL 71

Human   166 Q----QPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPA 226
            .    .||:....|..|..:.....|  ..|| :..||:|:           ...:..:.:|.|:
  Fly    72 TSDTGNPLMNSQGAQIFLTICGDENS--DDSQ-EYYTIKQE-----------PGCDLDIHSLLPS 122

Human   227 TVQTVAAPQVQQVPVLVQPQIIK-TDSLVLTTLKTDGSPVMAAV--------QNPALTALTTPIQ 282
            .:|   .|...|:|...:..::| |.||:      ...|..||:        :.|.|.::||...
  Fly   123 NLQ---LPNNLQLPTGCEIYLVKETGSLM------GEPPTKAAIKLELDTLSEKPLLPSVTTSSS 178

Human   283 TAALQV------PTLVG------SSGTILTTMPVMMG----------------QEKVPIKQVPGG 319
            |.:..:      |.:.|      |:.:..||..|:.|                .:.....|.|..
  Fly   179 TQSAVITAQTVNPPIPGNINTTTSTTSTTTTTSVLYGSHGNGHGHGHAHAQARSQPESAGQTPSS 243

Human   320 VKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLV---------------------MGTDAK 363
            ..:....::.:||.|||.:|:|.|..||..|.:||:::                     ..|:..
  Fly   244 KLEAYKKRDDKRRATHNEVERRRRDKINSWIFKLKEMLPSLSSSSSFSEASTSPSTSGSTSTNGS 308

Human   364 MH-----------------KSGVLRKAIDYIKYLQ-----------------QVNHKLRQE---- 390
            .|                 ||.:|.||.:|||.:|                 ..|..||:|
  Fly   309 SHSKGNASSSSGRAPPNDSKSQILIKACEYIKSMQGEIDTLRDCLRETDSLRASNQALREELDRL 373

Human   391 -------------------NMVLKLANQK--NKLLKGID-------LGSLVDNEVDLKIEDFNQ 426
                               |:.|...|..  :.|.:|||       :.||...:..|.|.||::
  Fly   374 KRQQQLQERFHTAGGRSTFNVTLNSLNSSATSDLFEGIDTTPNLAAVSSLGFGKRGLLISDFDE 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SREBF2	NP_004590.2	Transcriptional activation (acidic). /evidence=ECO:0000250\|UniProtKB:P36956	1..50
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..144		9/37 (24%)
		Interaction with LMNA. /evidence=ECO:0000250\|UniProtKB:Q3U1N2	237..491		64/314 (20%)
		HLH	331..381	CDD:278439	23/87 (26%)
		Leucine-zipper	380..401		8/62 (13%)
Usf	NP_572167.3	HLH	255..343	CDD:278439	23/87 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940