Protein Alignment SREBF2 and Srebf2

DIOPT Version :10

• Sequence 1: NP_004590.2
• Gene: SREBF2 / 6721
• HGNCID: 11290
• Length: 1141
• Species: Homo sapiens
• Sequence 2: NP_001028866.2
• Gene: Srebf2 / 300095
• RGDID: 1307751
• Length: 1133
• Species: Rattus norvegicus
• Alignment Length: 1141
• Identity: 1053/1141 - (92%)
• Similarity: 1097/1141 - (96%)
• Gaps: 8/1141 - (0%)

Human     1 MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGSGGSGSSSG 65
            ||::.|||||||||||||||||||||||||||||||||||||.|||||||||||||.||   .||
  Rat     1 MDENSELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFSDLFSEQLCSSFPGGGG---GSG 62

Human    66 SSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTSVPTTPRATPI 130
            |.|:|::|| |||:|.||.||:|||||:||.|.:||||:.|||||.||||||    ||.|||||:
  Rat    63 SGGTSNNSS-GRGTSGGAADPAVQRSFSQVPLSTFSPSSTSPQAPALQVKVS----PTPPRATPV 122

Human   131 LQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQ 195
            |||||||||||..|||||||||||||||.||||||||||||||||||||||||||||||||||||
  Rat   123 LQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQ 187

Human   196 PVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKT 260
            |||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||
  Rat   188 PVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVATPQVQQVPVLVQPQIIKTDSLVLTTLKT 252

Human   261 DGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEP 325
            ||||||||||||||||||.|||||||||||||||:|.||||||||||||||||||||||||||||
  Rat   253 DGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGAILTTMPVMMGQEKVPIKQVPGGVKQLEP 317

Human   326 PKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQE 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   318 PKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQE 382

Human   391 NMVLKLANQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGS 455
            ||||||||||||||||||||||||::|||||:|||||||||||||||||||||||||||||||||
  Rat   383 NMVLKLANQKNKLLKGIDLGSLVDSDVDLKIDDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGS 447

Human   456 PLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRS 520
            |||||||||||||||||||||||||||||||||||.||||||||||||||||:.||||:|||||:
  Rat   448 PLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLGLSFNPLTSLLQWGGAHNPDQHPYSGSGRN 512

Human   521 VLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDL 585
            |||.|||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||
  Rat   513 VLSLESGSGGWFDWMMPTLLLWLLNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDL 577

Human   586 ARGDFAAAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPA 650
            |:|||||||.||||||:|||||||||||||||||||||||||||||||||||||||||..|||||
  Rat   578 AKGDFAAAAANLQTCLSVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQRWRATPA 642

Human   651 TEAGFEDEAKTSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVE 715
            |.||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   643 TAAGFEDEAKSSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVE 707

Human   716 IHLTAAMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSA 780
            |||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||:|||
  Rat   708 IHLTAAMGLKTRCGGKLGFLASYFLNRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSIKSA 772

Human   781 AKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLH 845
            ||:||||||||||||||||||||||:|||||:|:||||||||||||:||||||||||||:|||||
  Rat   773 AKDSLYCAQRNPADPIAQVHQAFCKHLLERAVEALVKPQAKKKAGDREEESCEFSSALEFLKLLH 837

Human   846 SFVDSVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALE 910
            |||||||.::.|.|.||||:||||||::|||||||||||||||||||||||||||:|||:|||||
  Rat   838 SFVDSVGFVASPFSSSSVLRSALGPDVVCRWWTSAITVAISWLQGDDAAVRSHFTEVERVPKALE 902

Human   911 VTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSGATSDPALNHVVQLLT 975
            |||||||||:|:|||||||||.|||||||:||||||||||||||||||||.||||:|||||||.|
  Rat   903 VTESPLVKAVFYACRAMHASLSGKADGQQNSFCHCERASGHLWSSLNVSGTTSDPSLNHVVQLFT 967

Human   976 CDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVR 1040
            |||||||||.||||||||||.:||||||||.||||||||||||||||||||||||||||||||||
  Rat   968 CDLLLSLRTTLWQKQASASQLLGETYHASGTELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVR 1032

Human  1041 LMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLACRHLPLSFLSSPGQRAVL 1105
            ||||||||||||||||||||||||:|||||||.||||||||||||||||||||||||||||||||
  Rat  1033 LMAGASPTRTHQLLEHSLRRRTTQNTKHGEVDTWPGQRERATAILLACRHLPLSFLSSPGQRAVL 1097

Human  1106 LAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIAAS 1141
            |||||||||||||||||:||||||||||||||||||
  Rat  1098 LAEAARTLEKVGDRRSCSDCQQMIVKLGGGTAIAAS 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBF2	NP_004590.2	Transcriptional activation (acidic). /evidence=ECO:0000269|PubMed:35120642	1..50		44/48 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..144		67/95 (71%)
		Interaction with LMNA. /evidence=ECO:0000250|UniProtKB:Q3U1N2	237..491		247/253 (98%)
		bHLHzip_SREBP2	326..402	CDD:381492	75/75 (100%)
		Leucine-zipper	380..401		20/20 (100%)
Srebf2	NP_001028866.2	Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956, ECO:0000250|UniProtKB:Q12772	1..50		44/48 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	56..136		59/87 (68%)
		Interaction with LMNA. /evidence=ECO:0000250|UniProtKB:Q3U1N2	229..483		247/253 (98%)
		bHLHzip_SREBP2	318..394	CDD:381492	75/75 (100%)
		Leucine-zipper	372..393		20/20 (100%)