Protein Alignment SREBF2 and sre1

DIOPT Version :10

• Sequence 1: NP_004590.2
• Gene: SREBF2 / 6721
• HGNCID: 11290
• Length: 1141
• Species: Homo sapiens
• Sequence 2: NP_595694.1
• Gene: sre1 / 2540730
• PomBaseID: SPBC19C2.09
• Length: 900
• Species: Schizosaccharomyces pombe
• Alignment Length: 1031
• Identity: 202/1031 - (19%)
• Similarity: 333/1031 - (32%)
• Gaps: 388/1031 - (37%)

Human    94 QVTLPSFSPSAASP--QAPTLQV--KVSPTSVPTTPRATPILQPRPQPQPQPQTQ---------- 144
            |.::||.|.|.|||  :.||...  ..||.||...|.::|:..........|..:
pombe     2 QSSIPSVSVSVASPAMETPTKASPDSKSPNSVGAIPSSSPLASSTKASTSTPFVENCSNLLCDLA 66

Human   145 --LQQQTVMITPTFSTTPQTRIIQ----------QPLIYQNAATSFQVLQPQVQSLVTSSQV--- 194
              ::.....:|.| |.:|.:..:.          .|..:.|...|       ...|.||:.:
pombe    67 SIVEDSPPTLTNT-SLSPHSFSLSDMESSMSNWLNPFAFDNTMNS-------APPLFTSTNMGSP 123

Human   195 ---------------QPVTIQQQVQT------------VQAQRVLTQTANGTLQTLAPATVQTVA 232
                           .|.:.|.:..|            :|.|..:..    ::.|:.|:|||...
pombe   124 NSLENSTNPLLSNCGSPNSFQNETFTGPSLNEFDADDKIQRQMKILH----SVDTIDPSTVQNYP 184

Human   233 APQVQQVPVLVQPQI-IKTDSLVL---TTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVG 293
            :..:.      .|:: :||:.::.   ||.|.:.|.....:...:..:.:.| :|.....|...|
pombe   185 SADMS------NPEVKLKTEEIITPMDTTCKPEPSAKKIKLSPSSEDSCSIP-ETLPFSAPKSRG 242

Human   294 SSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVM 358
            |          :...|.......|||     .||    :|.||:||||||:::||:|.||:|.|.
pombe   243 S----------LSPSETPDFVAGPGG-----KPK----KTAHNMIEKRYRTNLNDRICELRDAVP 288

Human   359 GTDA----------------------KMHKSGVLRKAIDYIKYLQQVNHKLRQENMVL--KLANQ 399
            ...|                      |::|..:|.||.:||::|:..|.:|::.|..|  :||..
pombe   289 SLRAAAALRCGNSLDDEDLGGLTPARKLNKGTILAKATEYIRHLEAKNKELQKTNKQLSDRLAFY 353

Human   400 KNKLLKGIDLGSLVDNEVDLKIEDFNQNVLLMSPPASD-----SGSQAGFSPYSI--DSEPG--- 454
            ::.                           .|:||::|     |.:....|.||:  .|.|.
pombe   354 EDP---------------------------SMAPPSNDTRAVNSVNVVSSSDYSVHQSSRPNLTQ 391

Human   455 ----SPLLDDAKVKDEPDSPPVALGMV-----DRSRI---LLCVLTFLCLSF--NPLTSLLQWGG 505
                ||.|:  .:.....:..|.||:.     |.|:.   |..:..||...|  ..|.::|:.|.
pombe   392 RAFTSPTLN--TMGRTALNGMVGLGLFNYFGNDSSQSVYGLFALPPFLMSPFTGTVLFNMLKIGV 454

Human   506 A--------HDSDQHP-HSGSGRSVLSFESGSGGWFDWMMPTLLLW----------LVNGVIVLS 551
            .        ||:.... ..|..:|.:|..|.       |.|:.:|:          |.:....:|
pombe   455 VLLGLFYLLHDNSLFKGFKGEKKSKVSTRSS-------MSPSSILFRKTVFEKYCLLDHSTSTIS 512

Human   552 VFVKLLVHGEPVIRPHSRSSVTFWRHR-------------------------KQADLDLARGD-- 589
            :|..||:.       ..:|:..:..||                         |..|..|..||
pombe   513 LFFGLLIF-------TLKSAYGYLTHRLSALYTSSENWVYSEQQLAEVRNMEKLLDAQLMGGDAK 570

Human   590 ---------FAAAAG---NLQTC--------LAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLV 634
                     ||::..   :..||        |.....::|::.:....:..||
pombe   571 VDRLRLLMVFASSFSLPPSSHTCALQAMYCQLIFSNTSVPSAIVSKCVAFFWN------------ 623

Human   635 RWLLKKVFQCRRATPATEAGFEDEAKTSARDAALAYHRLHQL-HITGKLPAGSACSDV---HMAL 695
                              |..:..:|:|      .:..|.:| ..|..|...|...||   :|..
pombe   624 ------------------AAKKQHSKSS------VHAELRELPECTANLIENSHADDVFSPNMVE 664

Human   696 CAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYF------------LSRAQ---- 744
            ....||:|..:....|..:...|:..:.|     ..|..|||::            |||..
pombe   665 RLWVLAKCTRDSAQMSDSIISSLSDVLVL-----SPLEVLASWYAADLLDALLMESLSRKVEISE 724

Human   745 -----SLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSAAKESLYCAQRNPADPIAQVHQAFC 804
                 ||| |::|::                      ::.|....|.....|.||.:.:|..|:
pombe   725 IEEIISLC-PKNSSI----------------------IRHALLAKLVLFPENTADSLNEVLAAY- 765

Human   805 KNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSPPLSRSSVLKSALG 869
            ||.|:...:            |:.::|......|..|..|||      .:|..|.|       ||
pombe   766 KNTLDLCSQ------------DKRKQSSVLKINLSKLFTLHS------CLSLALQR-------LG 805

Human   870 -PDIICRWW-----------TSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTE 913
             .|:..|.:           .:.::..|||      ...:.|..:...||..:|.|
pombe   806 YGDVSKRMYQEIFVPDSDADITPLSFIISW------TALNTFAPICTSPKENDVVE 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBF2	NP_004590.2	Transcriptional activation (acidic). /evidence=ECO:0000269|PubMed:35120642	1..50
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..144		17/53 (32%)
		Interaction with LMNA. /evidence=ECO:0000250|UniProtKB:Q3U1N2	237..491		69/303 (23%)
		bHLHzip_SREBP2	326..402	CDD:381492	33/99 (33%)
		Leucine-zipper	380..401		7/22 (32%)
sre1	NP_595694.1	bHLHzip_scHMS1_like	259..354	CDD:381405	33/98 (34%)
		DUF2014	516..766	CDD:430604	54/321 (17%)