Protein Alignment SREBF2 and Srebf2

DIOPT Version :10

• Sequence 1: NP_004590.2
• Gene: SREBF2 / 6721
• HGNCID: 11290
• Length: 1141
• Species: Homo sapiens
• Sequence 2: NP_150087.1
• Gene: Srebf2 / 20788
• MGIID: 107585
• Length: 1130
• Species: Mus musculus
• Alignment Length: 1141
• Identity: 1047/1141 - (91%)
• Similarity: 1092/1141 - (95%)
• Gaps: 11/1141 - (0%)

Human     1 MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGSGGSGSSSG 65
            ||:|.|||.|||||||||||||||||||||||||||||||||||||||||||||||       .|
Mouse     1 MDESSELGVLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPG-------GG 58

Human    66 SSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTSVPTTPRATPI 130
            |:|.|.::|:|||::.||.||:|||||:||.|.:|||||||||||.||||||    ||.|||||:
Mouse    59 SNGGSGNNSSGRGNNGGATDPAVQRSFSQVPLSTFSPSAASPQAPALQVKVS----PTPPRATPV 119

Human   131 LQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQ 195
            |||||||||||..|||||||||||||||.||||||||||||||||||||||||||||||||.|||
Mouse   120 LQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSPQVQ 184

Human   196 PVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKT 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   185 PVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKT 249

Human   261 DGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEP 325
            ||||||||||||||||||.|||||||||||||||:||||||||||||||||||||||||||||:|
Mouse   250 DGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGTILTTMPVMMGQEKVPIKQVPGGVKQLDP 314

Human   326 PKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQE 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   315 PKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQE 379

Human   391 NMVLKLANQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGS 455
            ||||||||||||||||||||||||::|||||:|||||||||||||||||||||||||||||||||
Mouse   380 NMVLKLANQKNKLLKGIDLGSLVDSDVDLKIDDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGS 444

Human   456 PLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRS 520
            |||||||||||||||||||||||||||||||||||.||||||||||||||||::||||:||||||
Mouse   445 PLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLGLSFNPLTSLLQWGGAHNTDQHPYSGSGRS 509

Human   521 VLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDL 585
            |||.|||:|||||||:|||||||||||||||||||||||||||||||||.|||||||||||||||
Mouse   510 VLSLESGAGGWFDWMVPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRPSVTFWRHRKQADLDL 574

Human   586 ARGDFAAAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPA 650
            |:|||||||.||||||:|||||||||||||||||||||||||||||||||||||||||..|||||
Mouse   575 AKGDFAAAAANLQTCLSVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQRWRATPA 639

Human   651 TEAGFEDEAKTSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVE 715
            |.||||||||:|||||||||||||||||||||||||||||||||||||||||||||||.||||:|
Mouse   640 TAAGFEDEAKSSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKILPSTLIE 704

Human   716 IHLTAAMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSA 780
            |||||||||||||||||||||||||:|||||||||||.|||||||||||||||||||||||:|||
Mouse   705 IHLTAAMGLKTRCGGKLGFLASYFLNRAQSLCGPEHSTVPDSLRWLCHPLGQKFFMERSWSIKSA 769

Human   781 AKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLH 845
            ||||||||||:||||||||||||||||||||:|||||||||||||||||||||||||||||||||
Mouse   770 AKESLYCAQRSPADPIAQVHQAFCKNLLERAVESLVKPQAKKKAGDQEEESCEFSSALEYLKLLH 834

Human   846 SFVDSVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALE 910
            |||||||.::.|.|.||||:||||||:||||||||:|:||||||||||||||.||:|||:|||||
Mouse   835 SFVDSVGFVTSPFSSSSVLRSALGPDVICRWWTSAVTMAISWLQGDDAAVRSRFTEVERVPKALE 899

Human   911 VTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSGATSDPALNHVVQLLT 975
            |||||||||:|:.||||||||.|||||||:||||||||||||||||||||.||||:||||:||.|
Mouse   900 VTESPLVKAVFYTCRAMHASLSGKADGQQNSFCHCERASGHLWSSLNVSGTTSDPSLNHVIQLFT 964

Human   976 CDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVR 1040
            ||||||||||||||||||||.:||||||||.||||||||||||||||||||||||||||||||||
Mouse   965 CDLLLSLRTALWQKQASASQLLGETYHASGTELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVR 1029

Human  1041 LMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLACRHLPLSFLSSPGQRAVL 1105
            |||||||||||||||||||||.||:|||||||.||||||||||||||||||||||||||||||||
Mouse  1030 LMAGASPTRTHQLLEHSLRRRPTQNTKHGEVDTWPGQRERATAILLACRHLPLSFLSSPGQRAVL 1094

Human  1106 LAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIAAS 1141
            |||||||||||||||||:||||||||||||||||||
Mouse  1095 LAEAARTLEKVGDRRSCSDCQQMIVKLGGGTAIAAS 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBF2	NP_004590.2	Transcriptional activation (acidic). /evidence=ECO:0000269|PubMed:35120642	1..50		45/48 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..144		64/95 (67%)
		Interaction with LMNA. /evidence=ECO:0000250|UniProtKB:Q3U1N2	237..491		247/253 (98%)
		bHLHzip_SREBP2	326..402	CDD:381492	75/75 (100%)
		Leucine-zipper	380..401		20/20 (100%)
Srebf2	NP_150087.1	Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956, ECO:0000250|UniProtKB:Q12772	1..50		45/48 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..133		59/90 (66%)
		Interaction with LMNA. /evidence=ECO:0000269|PubMed:11929849	226..480		247/253 (98%)
		bHLHzip_SREBP2	315..391	CDD:381492	75/75 (100%)
		Leucine-zipper	369..390		20/20 (100%)