Protein Alignment SREBF2 and sbp-1

DIOPT Version :10

• Sequence 1: NP_004590.2
• Gene: SREBF2 / 6721
• HGNCID: 11290
• Length: 1141
• Species: Homo sapiens
• Sequence 2: NP_499472.1
• Gene: sbp-1 / 176574
• WormBaseID: WBGene00004735
• Length: 1113
• Species: Caenorhabditis elegans
• Alignment Length: 1133
• Identity: 278/1133 - (24%)
• Similarity: 449/1133 - (39%)
• Gaps: 232/1133 - (20%)

Human    44 DLFSEQLC-SSFPGSGGSGSS-------SGSSGSSSSSSNGRGSSSGAVDPS-VQRSFT---QVT 96
            |.||.:.. .:|...||.|.|       ||...:|..:.......||...|: ..|..:   |:.
 Worm    88 DFFSMRFSPPNFDLGGGRGPSLAATQQLSGEGPASMLNPLQTSPPSGGYPPADAYRPLSLAQQLA 152

Human    97 LPSFSPSAASPQAPTLQVKVSPTSVPTTPRATPILQP--RPQPQPQPQTQLQQQTVMITPTFSTT 159
            .|:.:|.    ||.:|.|..:.........|  :|.|  .....|||.|:..:.   |....|..
 Worm   153 APAMTPH----QAASLFVNTNGIDQKNFTHA--MLSPPHHTSMTPQPYTEAMEH---INGYMSPY 208

Human   160 PQTRIIQQPLIY----QNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTL 220
            .|.:....|..|    |:.........|..:......||...:|:.
 Worm   209 DQAQGPSGPSYYSQHHQSPPPHHHHHHPMPKIHENPEQVASPSIED------------------- 254

Human   221 QTLAPATVQT-VAAPQVQQVPVLVQPQIIKTDSLV------LTTLKTDGSPVMAAVQNPALT--- 275
               ||.|..| :..||..:.|..::.::::.  ||      :..||...|...:|...|:.:
 Worm   255 ---APETKPTHLVEPQSPKSPQNMKEELLRL--LVNMSPSEVERLKNKKSGACSATNGPSRSKEK 314

Human   276 ALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQ-------LEPPKEGERRT 333
            |....||..|                    .|.|....:....|...       :..||. ||||
 Worm   315 AAKIVIQETA--------------------EGDEDEDDEDSDSGETMSQGTTIIVRRPKT-ERRT 358

Human   334 THNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLK-LA 397
            .||:|||:||.||||:|.:||.|:.|.:||:.||..||:||::|   ::|.|    ||.||| ..
 Worm   359 AHNLIEKKYRCSINDRIQQLKVLLCGDEAKLSKSATLRRAIEHI---EEVEH----ENQVLKHHV 416

Human   398 NQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAK 462
            .|..|.|                     ||..|..|........:..||  ::|.| ||..::.|
 Worm   417 EQMRKTL---------------------QNNRLPYPEPIQYTEYSARSP--VESSP-SPPRNERK 457

Human   463 VKDEPDSPPVALGMVD-RSRILLCVLTFLCLSFN------------------PLTSLLQWGGAHD 508
            ......:.|:..|..| .|::.|..:....|.||                  |:.|..:.|...|
 Worm   458 RSRMSTTTPMKNGTRDGSSKVTLFAMLLAVLIFNPIGLLAGSAIFSKAAAEAPIASPFEHGRVID 522

Human   509 SDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVT 573
            .   |...|.|::.        |...::....:|:.|.::::.|.||||:||:||....|.|..|
 Worm   523 D---PDGTSTRTLF--------WEGSIINMSYVWVFNILMIIYVVVKLLIHGDPVQDFMSVSWQT 576

Human   574 FWRHRKQADLDLARGDFAAAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLL 638
            |...|::|..:|..|:...|......|||.|.|:||:..:|...|:.|..:|:.|..|    |:.
 Worm   577 FVTTREKARAELNSGNLKDAQRKFCECLATLDRSLPSPGVDSVFSVGWECVRHLLNWL----WIG 637

Human   639 KKVFQCRRAT--PATEAGFEDEAKTSARDAALAYHRLHQLH---ITGKLP---AGSACSDVHMAL 695
            :.:.:.||:|  |.:..     .::.|:.|.| ||.:||||   |||...   ..||.:.:.|:|
 Worm   638 RYIARRRRSTTKPVSVV-----CRSHAQTAVL-YHEIHQLHLMGITGNFEDTYEPSALTGLFMSL 696

Human   696 CAVNLAECA---EEKIPPSTLVEIHLTAAMGLKTRCGGKLG-FLASYFLSRAQSLC--GPEHSAV 754
            |||||||.|   .:.:|.:.:.:|:::|::..:......|. |.:.|||.||:...  .||||.
 Worm   697 CAVNLAEAAGASNDGLPRAVMAQIYISASIQCRLALPNLLAPFFSGYFLRRARRHVRRAPEHSV- 760

Human   755 PDSLRWLCHPLGQKFFME--RSWSVKSAAKESL---YCAQRNPADPIAQVHQAFCKNLLERAIES 814
             ..|.|:.||..:||..:  |...|.|:.::.|   ...:.....|:|::.......||.:.::.
 Worm   761 -SHLLWIFHPATRKFMSDAKRLEHVLSSKQKQLRFGSFVEDEQLSPLARIRTTLKVYLLSKLVQE 824

Human   815 LVKPQAKKKAGDQEEESCEFSSALEYL----KLLHSFVDSVGVMSPPLSRSSVLKSAL------- 868
            ||       .||:     .|:..:|.:    ..|...||.|.|....::.|:...:.|
 Worm   825 LV-------GGDE-----IFTKNVERILNDNDRLDDEVDVVDVSRLLVTISTQCAAILTNEKDES 877

Human   869 ---------GPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTESPLVKAIFHAC 924
                     ..|..|.|||..:|..|.|....:...|.|::.:...|..: :|:: |..|:.||.
 Worm   878 AKFGTWISRNGDACCTWWTHVLTCGIYWRSNKNELARQHYSLIRNCPPKI-LTDN-LGLAVGHAL 940

Human   925 RAMHASLPGKADGQQSSF-C-HCERA--SGHLWS-SLNVSGATSDPALNHVVQLLTCDLLLSLRT 984
            .|....:..:...:.|.: | |.:::  |..|:| |...||..|  .:....:.:..:.:::...
 Worm   941 CARKICIDDRDSPKVSQYVCIHTKKSLESLRLFSTSSRASGVVS--GIQEGTRRMAYEWIMNSLL 1003

Human   985 ALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTR 1049
            ..|:....||:..........:..:...::..:...:.:..|....::|::|.|.|::.||:|..
 Worm  1004 DAWRSNLFASKPYWTQSFKGQSTFSTLYQEAYNHYAIINGTRGDCWRLFVYELTCRMLNGANPQA 1068

Human  1050 THQLLEHSLRRRTTQSTKHGEVDAWPGQ 1077
            |..    .:||  .:|||   :||..|:
 Worm  1069 TWS----GVRR--VRSTK---MDAVRGR 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBF2	NP_004590.2	Transcriptional activation (acidic). /evidence=ECO:0000269|PubMed:35120642	1..50		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..144		25/109 (23%)
		Interaction with LMNA. /evidence=ECO:0000250|UniProtKB:Q3U1N2	237..491		72/271 (27%)
		bHLHzip_SREBP2	326..402	CDD:381492	39/76 (51%)
		Leucine-zipper	380..401		8/21 (38%)
sbp-1	NP_499472.1	Atrophin-1	30..>275	CDD:460830	46/217 (21%)
		bHLH_SF	351..423	CDD:469605	40/79 (51%)