Protein Alignment SREBF2 and srebf2

DIOPT Version :9

• Sequence 1: NP_004590.2
• Gene: SREBF2 / 6721
• HGNCID: 11290
• Length: 1141
• Species: Homo sapiens
• Sequence 2: XP_012816036.1
• Gene: srebf2 / 100144677
• XenbaseID: XB-GENE-1011360
• Length: 1096
• Species: Xenopus tropicalis
• Alignment Length: 1137
• Identity: 776/1137 - (68%)
• Similarity: 906/1137 - (79%)
• Gaps: 50/1137 - (4%)

Human    10 LETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGSGGSGSSSGSSGSSSSSS 74
            :|.||||||||||||||||||||||||||||:|||||.||||.|:.|
 Frog     5 MENMETLTELGDELTLGDIDEMLQFVSNQVGDFPDLFEEQLCQSYQG------------------ 51

Human    75 NGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTSVPTTPRATPILQPRPQPQP 139
                  :.|::.::.:::.|.  |....:.::||..||.|| :|:.| |..|..|:|||||..|.
 Frog    52 ------NNAMETALPKAYNQA--PQQPYTTSTPQPQTLPVK-APSQV-TPQRTAPLLQPRPVIQS 106

Human   140 QPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQ 204
            .||.||||||||:||.|||.||||||||||||||||||||||||.||||:|:.|:||||||||||
 Frog   107 SPQPQLQQQTVMLTPNFSTAPQTRIIQQPLIYQNAATSFQVLQPPVQSLMTTQQMQPVTIQQQVQ 171

Human   205 TVQAQRVLTQTANGTLQTLAPA-TVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAA 268
            ||||||||||.||||:|||.|| ||||| .|||||||||||||||||:|||||.:|.||||||..
 Frog   172 TVQAQRVLTQAANGTIQTLTPATTVQTV-TPQVQQVPVLVQPQIIKTESLVLTAVKADGSPVMTT 235

Human   269 VQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRT 333
            :||||:|.|.|||||.|||||||:||:|||||||||||||||:|||||||.:||.|.||||||||
 Frog   236 MQNPAITTLATPIQTTALQVPTLMGSNGTILTTMPVMMGQEKMPIKQVPGSLKQPEVPKEGERRT 300

Human   334 THNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLAN 398
            |||||||||||||||||||||||||||||||||||||:|||||||||||||.|||||||.|||||
 Frog   301 THNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLKKAIDYIKYLQQVNQKLRQENMALKLAN 365

Human   399 QKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKV 463
            ||||.||||||.||||..:.:|:::||||:|:||||||||||.|.|||||:|||||||||||.||
 Frog   366 QKNKYLKGIDLSSLVDTSIGMKMDEFNQNILMMSPPASDSGSPAVFSPYSVDSEPGSPLLDDEKV 430

Human   464 KDEPDSPPVALGMVDRSRILLCVLTFLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGS 528
            |||||| |..|||:||||:|||.:||||||||||||||.......:::..| |:||::|..|:..
 Frog   431 KDEPDS-PTGLGMMDRSRMLLCTMTFLCLSFNPLTSLLHSESGQYTERVQH-GTGRTMLGIETSG 493

Human   529 --GGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFA 591
              |.||||::|||:|||||||||||||:|||:|||||.|.||||||.|||||||||||||:|||.
 Frog   494 FYGSWFDWLIPTLILWLVNGVIVLSVFMKLLIHGEPVTRLHSRSSVKFWRHRKQADLDLAKGDFG 558

Human   592 AAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLK-KVFQCRRATPATEAGF 655
            |||.||||||.||||:||.||.|||||||||:||.||||:.||||||| ....|::|.      |
 Frog   559 AAAINLQTCLCVLGRSLPASRFDLACSLSWNIIRCSLQKISLVRWLLKHSPGYCKKAE------F 617

Human   656 EDEAKTSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTA 720
            :|||.||||||||.||:|||||:|||||:...||.:::|||||||||||..||.|:.|.|||||.
 Frog   618 QDEATTSARDAALVYHKLHQLHLTGKLPSNWNCSGLNLALCAVNLAECAGNKISPNLLAEIHLTT 682

Human   721 AMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSAAKESL 785
            |:.:||....:..||.:|||..||:....|  ::||.:|||.||||:.||:..:|::||..|:||
 Frog   683 AIQMKTSFPSRFRFLTAYFLGCAQNASSEE--SLPDPVRWLAHPLGKYFFINSNWALKSVTKDSL 745

Human   786 YCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDS 850
            |.:.||||||:.|:|:|||::|||:|:.::.||:..|  ...||||||||.|.||||||..|.||
 Frog   746 YTSTRNPADPVTQIHRAFCESLLEKAMYTMAKPETSK--APPEEESCEFSRAQEYLKLLSGFADS 808

Human   851 VG-VMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTES 914
            || :.|.|||.||.:.||   |.|||||.|..::||.||||||:.|:|||.:||||||.|: :::
 Frog   809 VGNIASLPLSGSSPMSSA---DPICRWWYSVSSMAIGWLQGDDSVVKSHFAEVERIPKLLD-SDN 869

Human   915 PLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSGATSDPALNHVVQLLTCDLL 979
            |||||:.|.||||.|::.||.||.||||.|||:||..||:|||:|...|...||.|||||.||||
 Frog   870 PLVKAVIHMCRAMQAAVLGKCDGPQSSFYHCEKASTFLWNSLNMSSTGSYANLNKVVQLLICDLL 934

Human   980 LSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAG 1044
            |||||:|||||:|:|.|.||:.||..:.|.||||||.||||||.:|:||:.|:||||||||||||
 Frog   935 LSLRTSLWQKQSSSSPAAGESIHAPTSVLTGFQRDLSSLRRLALTFKPAHCKLFLHEATVRLMAG 999

Human  1045 ASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEA 1109
            ||||||||||:|||::||..:.|.|::|:.||||||||||||||||||||||||||||||:||||
 Frog  1000 ASPTRTHQLLQHSLQKRTALANKQGDLDSLPGQRERATAILLACRHLPLSFLSSPGQRAVMLAEA 1064

Human  1110 ARTLEKVGDRRSCNDCQQMIVKLGGGTAIAAS 1141
            ||||||||||||.:|||||:|||.||||:|||
 Frog  1065 ARTLEKVGDRRSYHDCQQMMVKLSGGTAMAAS 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBF2	NP_004590.2	Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956	1..50		35/39 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..144		28/95 (29%)
		Interaction with LMNA. /evidence=ECO:0000250|UniProtKB:Q3U1N2	237..491		209/253 (83%)
		HLH	331..381	CDD:278439	48/49 (98%)
		Leucine-zipper	380..401		18/20 (90%)
srebf2	XP_012816036.1	bHLHzip_SREBP2	293..369	CDD:381492	72/75 (96%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	991	1.000	Domainoid score	I674
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20966
Inparanoid	1	1.050	1481	1.000	Inparanoid score	I1439
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167699at33208
OrthoFinder	1	1.000	-	-		FOG0001476
OrthoInspector	1	1.000	-	-		oto155243
Panther	1	1.100	-	-	LDO	PTHR46062
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	1	1.000	-	-		X2374
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.190