Protein Alignment SREBF1 and srebf1

DIOPT Version :10

• Sequence 1: NP_001005291.1
• Gene: SREBF1 / 6720
• HGNCID: 11289
• Length: 1177
• Species: Homo sapiens
• Sequence 2: NP_001098599.2
• Gene: srebf1 / 793274
• ZFINID: ZDB-GENE-090812-3
• Length: 1105
• Species: Danio rerio
• Alignment Length: 1206
• Identity: 675/1206 - (55%)
• Similarity: 801/1206 - (66%)
• Gaps: 139/1206 - (11%)

Human     6 FSEAALEQ-----ALGEPCDLDAALLTDIEGEVGAGRGRANGLDAPRAGADRGAMDCTFEDMLQL 65
            |.:.:|:.     :|.:|.|:|.|||.||                              :|||||
Zfish     5 FDDTSLDTLDSSLSLHDPSDIDTALLNDI------------------------------DDMLQL 39

Human    66 INNQDSDFPGLFDPPYAGSGAGGTDPASPDT----SSPGS-----LSPPPATLSSS--LEAFLSG 119
            ||.||.:| ||||.      |....||:|..    |||.|     |...|:.||||  |:|.| |
Zfish    40 INTQDMEF-GLFDQ------ASFPAPAAPAQEQLHSSPASPAAAPLPAAPSILSSSPHLDALL-G 96

Human   120 PQAAPSPLSPPQPAPTPLKMYPSMPAFSPGPGIKEESVPLSILQT-PTPQPLPGALLPQSFPAPA 183
            |     |:|.....||.....|.  .|...|..:..|.|.::..| |..||.|.|.|..|  :..
Zfish    97 P-----PISRSSSIPTDKAFQPH--TFQQAPLAQVNSTPAALQTTQPKAQPAPSASLQPS--SQT 152

Human   184 PPQFSSTPVLGYPSPPGGFSTGSPPGNTQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTA 248
            ||..||:|.....|.....:|.:|.  |||       :||..:|.||  ...|::.|..:.:::|
Zfish   153 PPSASSSPQQTLYSSYTTHTTYTPV--TQQ-------SSPQSIPSVS--ASPQNIQPMTIQSLSA 206

Human   249 AP----TAAPVTTTVTSQIQQVPVLLQPHFIKADSLLLTAMKTD---GATVKAAGLSPLVSGTTV 306
            :|    :::|.|..:..|:||:||||||.||||||||||.:|.|   ..||.:..::.|.|...|
Zfish   207 SPILTASSSPPTQPLPPQVQQLPVLLQPQFIKADSLLLTTLKPDVTMVTTVASPCITTLTSTAPV 271

Human   307 QTGPLPTLVSGGTILATVPLVVDAEKLPINRLAAGSKAPASAQSRGEKRTAHNAIEKRYRSSIND 371
            |..||..|:||||||.|||||||.|||||||:|...| |.....:||||||||||||||||||||
Zfish   272 QNTPLQALMSGGTILTTVPLVVDTEKLPINRIAISGK-PGCQPHKGEKRTAHNAIEKRYRSSIND 335

Human   372 KIIELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLSLRTAVHKSKSLKDLVSACGS 436
            |||||||||.||||||||||||:|||:|||:||.|||||||||::|:..:.|:|||||||:
Zfish   336 KIIELKDLVAGTEAKLNKSAVLKKAIEYIRYLQQSNQKLKQENMALKMNIQKNKSLKDLVT---- 396

Human   437 GGNTDVLME-GVKTEVEDTLTPPPSDAGSPFQSSPLSLGSRGSGSGGSGSDSEPDSPVFEDSKAK 500
                   || .||.|:.   |||.||.|||..|.|.|..|         ||||||||:.||:||.
Zfish   397 -------MEVDVKPEIP---TPPASDVGSPQSSGPYSQHS---------SDSEPDSPMAEDNKAV 442

Human   501 PEQRPSLHSRGMLDRSRLALCTLVFLCLSCNPLASLL----GARGLPSPSDTTSVYHSPGRNVLG 561
            .|:     :.|||||||:|||....|.||.|||||||    .:.|...|.      ::.||:||.
Zfish   443 VER-----AGGMLDRSRMALCAFTLLFLSFNPLASLLCGGWSSAGASVPG------NAAGRSVLS 496

Human   562 TE-SRDGPGWAQWLLPP-VVWLLNGLLVLVSLVLLFVYGEPVTRPHSGPAVYFWRHRKQADLDLA 624
            .| |.:..||..|:||. :||||||:||...|:.|.|||||||||||..:|.|||||||||||||
Zfish   497 IEDSGESWGWMDWMLPTLLVWLLNGVLVAGVLIRLLVYGEPVTRPHSESSVLFWRHRKQADLDLA 561

Human   625 RGDFAQAAQQLWLALRALGRPLPTSHLDLACSLLWNLIRHLLQRLWVGRWLAGRAGGLQQDCALR 689
            |||||||:|.|...|:|||||||||.|||||::||:.:|..|||||||||||.|||.|:.:..|:
Zfish   562 RGDFAQASQNLRTCLKALGRPLPTSQLDLACAVLWSALRLCLQRLWVGRWLASRAGALRPNRPLQ 626

Human   690 VDASASARDAALVYHKLHQLHTMGKHTGGHLTATNLALSALNLAECAGDAVSVATLAEIYVAAAL 754
            .|...|.||||||||:|||||..||..|.||:|.::|||||||||||||.:.||||||:||:|||
Zfish   627 EDNCKSCRDAALVYHRLHQLHMTGKLGGSHLSAIHMALSALNLAECAGDCLPVATLAEVYVSAAL 691

Human   755 RVKTSLPRALHFLTRFFLSSARQACLAQSGSVPPAMQWLCHPVGHRFFVDGDWSVLSTPWESLYS 819
            ||||||||.|||.||.||||||||||:.||||||||||||||:|||||||.||::.|:|.||:||
Zfish   692 RVKTSLPRLLHFTTRVFLSSARQACLSPSGSVPPAMQWLCHPLGHRFFVDEDWTIRSSPRESIYS 756

Human   820 LAGNPVDPLAQVTQLFREHLLERALNCVTQPNPSPGSADGDKEFSDALGYLQLLNSCSDAAGAPA 884
            .|||.|||||||||.|||||||:||.||.||......||||.||||||.|||||.|.:|||||..
Zfish   757 QAGNSVDPLAQVTQGFREHLLEKALYCVAQPRGDKSLADGDGEFSDALEYLQLLTSAADAAGATT 821

Human   885 YSFSISSSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPLVEHLPRVLQESERPLPRAA 949
            .||:|.|:|||.||.||.:|||:|:..|||:||:.::.|||||.|.||||||.||.:|.|||:|.
Zfish   822 QSFAIGSNMATVTGCDPHSKWWSSMVVVVINWLQGEDAAAERLYPAVEHLPRSLQSAESPLPKAC 886

Human   950 LHSFKAARALLGCAKAESGPASLTICEKASGYLQDSLATTP---ASSSIDKAVQLFLCDLLLVVR 1011
            ::.|||.|.||  ||.||...||:.||:||...:|||...|   ||:.:||.|||.|||||||.|
Zfish   887 VNVFKAVRTLL--AKPESQQLSLSYCERASVLFRDSLNLGPHCSASTQLDKLVQLLLCDLLLVTR 949

Human  1012 TSLWRQQQPPAPAPAAQGTSSRPQASALELRGFQRDLSSLRRLAQSFRPAMRRVFLHEATARLMA 1076
            |::||.||       ...:||...||..||:|||:|||||||||.|||||.||:|||||||||||
Zfish   950 TNVWRDQQ-------VCSSSSTAAASPAELQGFQQDLSSLRRLAHSFRPATRRLFLHEATARLMA 1007

Human  1077 GASPTRTHQLLDRSLRRRAGPGGKGGAVAELEPRPTRREHAEALLLASCYLPPGFLSAPGQRVGM 1141
            |||||||||||||||||||.||.:   :.|.|..|.:||.|||::||..:|||.|||||||||||
Zfish  1008 GASPTRTHQLLDRSLRRRATPGAR---IEECELHPGQREQAEAVMLACRFLPPSFLSAPGQRVGM 1069

Human  1142 LAEAARTLEKLGDRRLLHDCQQMLMRLGGGTTVTSS 1177
            ||:||||||||||:|.|||||||:::||.||||||:
Zfish  1070 LADAARTLEKLGDKRTLHDCQQMIIKLGSGTTVTST 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBF1	NP_001005291.1	Herpes_BLLF1	<79..350	CDD:282904	111/289 (38%)
		Atrophin-1	<117..>240	CDD:460830	37/123 (30%)
		bHLHzip_SREBP1	349..423	CDD:381491	59/73 (81%)
srebf1	NP_001098599.2	helix-Loop-helix DNA binding domain	315..372		50/56 (89%)